第42回日本磁気共鳴医学会大会

講演情報

一般演題

磁化率画像

磁化率画像1

2014年9月19日(金) 09:30 〜 10:30 第3会場 (3F 源氏の間南)

座長:工藤與亮(北海道大学病院 放射線診断科)

[O-2-173] Stripe sign of precentral gyri in amyotrophic lateral sclerosis: a novel finding on PADRE

掛田伸吾1, 米田哲也2, 宮田真理1, 井手智1, 渡邉啓太1, 村上優1, 小笠原篤1, 森谷淳二1, 二ツ矢浩一郎1, 興梠征典1 (1.産業医科大学 放射線科, 2.熊本大学医学部 保健学科)

Purpose: To evaluate the signal-intensity (SI) of the precentral gyri (PG) in the amyotrophic lateral sclerosis (ALS) patients in comparison with healthy subjects (HS) by using a phase-weighted MR imaging technique “Phase Difference Enhanced Imaging (PADRE)”. Methods: The PADRE was performed in 5 ALS patients and 20 HS at 3T MRI system. For the PG on PADRE images, two radiologists compared the SI of the grey matter (GM) with the subcortical white matter (WM) and divided into 3 grades: hyperintense, isointense, or hypointense. Results: The GM of the PG was hyperintense to the subcortical WM in all 20 HS, and hypointense in all 5 ALS patients (Fig.). Furthermore, in ALS patients, four layers, high, low, high, and low SI from the pial surface of the PG, were seen on PADRE images, which seemed to correspond to the superficial GM, deeper GM, superficial subcortical WM, and deeper subcortical WM, respectively (stripe sign) (Fig. B). Conclusions: In ALS patients, the PADRE images showed the four layers in the PG, which might reflect the iron deposition in a part of the GM and the reduced concentration of myelin in the superficial subcortical WM.