Are inhibition constants (Ki) correctly estimated using only the blood concentration-time profile of substrate drugs with and without co-administration of inhibitor drugs?

Kota Toshimoto

Presentation information

Oral Presentation

[O6] 6．Drug interaction・Toxicity

Sat. Oct 15, 2016 9:00 AM - 10:12 AM Room 5 (The first meeting room)

Kiyomi Ito (Research Institute of Pharmaceutical Sciences, Musashino University), Akihiro Hisaka (Clinical Pharmacology and Pharmacometrics, Graduate School of Pharmaceutical Sciences, Chiba University), Yasuhiro Masubuchi (Chiba Institute of Science), Ryoichi Fujiwara (School of Pharmacy, Kitasato University), )

[O6-3] Are inhibition constants (Ki) correctly estimated using only the blood concentration-time profile of substrate drugs with and without co-administration of inhibitor drugs?

Kota Toshimoto ¹, Yukana Tomoda ^1,2, Koji Chiba ^1,2, Yuichi Sugiyama ¹ (1.Sugiyama Laboratory, RIKEN Innovation Center, RIKEN, 2.Clinical Pharmacology Research Laboratory, Yokohama University of Pharmacy)

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