Symposium

[S12] The forefront of drug discovery utilizing silkworms - Application for production of human biologics and disease models

Sat. Mar 26, 2022 1:30 PM - 3:30 PM [Room Q] Shirotori Hall (North) (Bldg. 4: 1F)

Organizer: Kazuhisa Sekimizu (Sch. Pharma-Sci., Teikyo Univ.), Kouji Itou (Grad. Sch. Pharmaceut. Sci., Tokushima Univ.)

Silkworm is a traditionally domesticated and sustainable insect for the industrial production of silk. Based on the remarkable ability of silkworms to overproduce silk proteins in silk glands and recent transgenic technology, gene-manufacturing (GM) silkworm strains have been developed to produce large amounts of drug substances for antibody pharmaceuticals and enzyme replacement therapy at a lower cost. Also, silkworms can be utilized for drug screening and efficacy evaluation due to the similarity in pharmacokinetics and drug response between humans and silkworms. In addition, silkworms, out of a target of animal welfare, are expected as substitution models for animal experiments. In this symposium, we introduce the recent advance in developing GM-silkworm overproducing glycoproteins available for biomedicine as GMP-grade pharmaceutical base materials. The safety and efficacy of glycol-engineered human lysosomal enzymes (CTSA and IDUA) for the disease model animals with the genetic enzyme deficiency will be presented. Furthermore, an application case of silkworms as human disease model reflecting cytokine storm pathology will be introduced.

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オーガナイザー挨拶：関水和久（帝京大薬） (1:30 PM - 1:35 PM)

1:35 PM - 1:55 PM

[S12-1] Development of genetically modified silkworms for the production of human/animal pharmaceutical proteins

Ken-ichiro Tatematsu¹, Megumi Sumitani¹, Mitsuru Sato¹, Masahiro Kusumoto¹, Katsura Kojima¹, Ryusei Izumi^1,2, Hiroki Sakai¹, Keiro Uchino¹, Shuichiro Tomita¹, Tetsuya Iizuka¹, Toshiki Tamura³, ○Hideki Sezutsu^1,2 (1. NARO, 2. Grad. Sch. Front. Sci., Univ. Tokyo, 3. Silk Sci. Tech. Res. Inst.)

1:55 PM - 2:15 PM

[S12-2] Production of biologics using transgenic silkworms as a novel biological substrate

○Seiki Yageta¹, Masahiro Tomita¹ (1. IBL)

2:15 PM - 2:35 PM

[S12-3] Development of neo-glycobiologics utilizing transgenic silkworm and natural glycan resources and functional evaluation

○Kohji Itoh¹, So-ichiro Nishioka¹, Chika Shinoda¹, Yoshie Takeuchi², Jun Tsukimoto¹, Yuya Sasai¹, Takao Oishi³, Satomi Nadanaka⁴, Hiroshi Kitagawa⁴, Akira Harazono⁵, Akiko Ishii⁵, Isao Kobayashi⁶, Megumi Sumitani⁶, Ken-ichiro Tatematsu⁶, Hideki Sezutsu⁶ (1. Grad. Sch. Pharmaceut. Sci., Tokushima Univ., 2. Facult. Pharmaceut. Sci., Tokushima Univ., 3. Primate Res. Inst., Kyoto Univ., 4. Kobe Pharmaceut. Univ., 5. NIHS, 6. NARO)

2:35 PM - 2:55 PM

[S12-4] Evaluation of efficacy and safety of gene-manufacturing silkworm-derived human alpha-iduronidase to a Japanese monkey affected by mucopolysaccharidosis type I

○Takao Oishi¹, Akihisa Kaneko¹, Takako Miyabe-Nishiwaki¹, Kohji Itoh² (1. Primate Res. Inst., Kyoto Univ., 2. Grad. Sch. Pharmaceut. Sci., Tokushima Univ.)

2:55 PM - 3:15 PM

[S12-5] Cytokine storm model using the silkworm and its drug discovery application

○Atsushi Miyashita¹, Kazuhisa Sekimizu² (1. Inst. Med. Mycol., Teikyo Univ., 2. Sch. Pharma-Sci., Teikyo Univ.)

総合討論・総括：伊藤孝司（徳島大院医歯薬） (3:15 PM - 3:30 PM)

Session information