Session information

Symposium

[S24] Mechanisms of aging and age-related diseases and their regulation: Dispatch of information from basic research

Sun. Mar 26, 2023 4:10 PM - 6:10 PM [Room D] Institute for the Advancement of Higher Education: S2 (Bldg. S: 2F)

Organizer: Ryoya Takahashi, Yoshikazu Higami

Various animal species such as yeast, nematodes, flies, fish, mice, rats, and monkeys are used for basic research on the mechanisms and regulation of aging and age-related diseases.
Although the lifespan and aging characteristics of each animal species are different, some common age-related changes at the molecular level are observed. On the other hand, recent gene modification technology has made a great contribution to the understanding of the molecular mechanisms of aging and age-related diseases. However, the aging characteristics of genetically modified animals, such as knockout mice, do not necessarily match those of normal animals, and this gave a glimpse of the difficulty of extrapolating them to humans.
In this symposium, I will first explain the purpose of the symposium and touch on the multifaceted aging of experimental animals (Organizer, R. Takahashi, Toho Univ.) Next, we will ask researchers in each specialized field to introduce the effectiveness and issues of intervention research by genetic modification and dietary restriction for the purpose of elucidating the onset mechanism of aging-related diseases (Assoc. Prof. Y. Tsuchiya, Toho Univ.; Prof. K. Shimokawa, Nagasaki Univ.; Prof. Y. Higami, Tokyo Univ. Sci.). At the end of this symposium, Prof. S. Goto (Juntendo Univ.), who has been involved in basic research on aging for many years, will talk about the difference between aging and diseases, model animals, theories of aging, and then discuss about the question of whether biological aging can be cured. This symposium will provide a good opportunity for discussion on the mechanisms of aging based on scientific knowledge for today and the future.

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4:10 PM - 4:20 PM

[S24-01] Dissemination of information from basic research on aging: Species and sex differences

○Ryoya Takahashi¹, Keiko Odera¹ (1. Fac. of Pharm. Sci., Toho Univ.)

4:20 PM - 4:45 PM

[S24-02] Aging-related cyst formation and fibrosis

○Yuichi Tsuchiya^1,2, Takao Seki², Hiroyasu Nakano², Minoru Tanaka³, Ryoya Takahashi¹ (1. Fac. of Pharm. Sci., Toho Univ., 2. Fac. of Med. Toho Univ., 3. Natl. Center Global Health Med.)

4:45 PM - 5:10 PM

[S24-03] Regulation of aging processes: A perspective of dietary restriction models

○Isao Shimokawa¹ (1. Nagasaki Univ. Grad. School of Biomed. Sci.)

5:10 PM - 5:35 PM

[S24-04] Regulation of aging and lifespan by white adipose tissue

Yuka Nozaki¹, Masaki Kobayashi³, ○Yoshikazu Higami^1,2 (1. Tokyo Univ. of Sci., Pharm. Sci., 2. Tokyo Univ. of Sci, Res. Inst. Biomed. Sci., 3. Ochanomizu Univ., Fac. Human Life & Environ. Sci.)