[26E2-am] Structure-activity relationship

Sun. Mar 26, 2023 11:00 AM - 12:00 PM [Room E2]Institute for the Advancement of Higher Education: E308 (Bldg. E: 3F)

Chair: Makoto Oba, Yuko Otani

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11:00 AM - 11:12 AM

[26E2-am11S] Development of bicyclic 5-OP-RU analogues as MAIT cell activators

○Ryosuke Takasaki¹, Takuro Matsuoka¹, Norihito Arichi¹, Sho Yamasaki^2,3, Hiroaki Ohno¹, Shinsuke Inuki¹ (1. Graduate School of Pharmaceutical Sciences, Kyoto Univ., 2. Research Institute for Microbial Diseases, Osaka Univ., 3. Immunology Frontier Research Center (IFReC), Osaka Univ.)

11:12 AM - 11:24 AM

[26E2-am12S] Synthesis of Acetogenin Thiophene Analogs Conformationally Fixed by Cyclopentane Rings and Clarification Research of Molecular Mechanism

○Hiroyuki Hosomi¹, Sawako Koshiba¹, Takuya Matsumoto¹, Shota Ando¹, Chiami Moyama¹, Hiromi Ii¹, Susumu Nakata¹, Hiroki Iwasaki¹, Masayuki Yamashita¹, Hisanori Nambu¹, Naoto Kojima¹ (1. Kyoto. Pharm. Univ.)

11:24 AM - 11:36 AM

[26E2-am13S] Synthesis and Antitumor Activity of Novel Analog of Acetogenin Thiophene Analog with Triethylene Glycol in place of THF Moiety

○Kaito Ohta¹, Masato Fujii¹, Chiami Moyama¹, Hiromi Ii¹, Susumu Nakata¹, Hiroki Iwasaki¹, Masayuki Yamashita¹, Hisanori Nambu¹, Naoto Kojima¹ (1. Kyoto Pharma. Univ.)

11:36 AM - 11:48 AM

[26E2-am14S] Evaluation of passive membrane permeability of alanyl-backbone peptoids

○Mariko Akiba¹, Jumpei Morimoto¹, Shinsuke Sando¹ (1. Grad. Sch. Eng., Univ. Tokyo)

11:48 AM - 12:00 PM

[26E2-am15] Evaluation of the Effect of an Amide-to-Ester Substitution on Membrane Permeability and Conformational Dynamics of a Cyclic Hexapeptide

○Jumpei Morimoto¹, Yuki Hosono¹, Moe Shinkai¹, Satoshi Uchida¹, Masatake Sugita^2,3, Takumi Ueda^1,4, Hsiau-Wei Lee⁵, Koh Takeuchi⁴, Yutaka Akiyama^2,3, Scott R. Lokey⁵, Shinsuke Sando¹ (1. Grad. Sch. Eng., Univ. Tokyo, 2. Sch. Comp., Tokyo Inst. Tech., 3. MIDL, Tokyo Inst. Tech., 4. Grad. Sch. Pharm. Sci., Univ. Tokyo, 5. Univ. Cal., Santa Cruz)

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