[26E2-pm] Chemical biology/Drug design

Sun. Mar 26, 2023 2:50 PM - 3:50 PM [Room E2]Institute for the Advancement of Higher Education: E308 (Bldg. E: 3F)

Chair: Fumi Nagatsugi, Noriaki Minakawa

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2:50 PM - 3:02 PM

[26E2-pm06S] Development of triplex forming oligonucleotides containing novel photo-reactive nucleosides

○Juki Nakao¹, Honoka Eshima¹, Yu Mikame¹, Tsuyoshi Yamamoto¹, Chikara Dohno², Takehiko Wada³, Asako Yamayoshi¹ (1. Grad. Sch. Biomed. Sci., Nagasaki Univ., 2. SANKEN, Osaka Univ., 3. IMRAM, Tohoku Univ.)

3:02 PM - 3:14 PM

[26E2-pm07] Antitumor effect of lipid-siRNAs for pancreatic cancer in a liver-metastatic tumor mouse model

○Takanori Kubo¹, Rina Tansou¹, Yoshio Nishimura², Keishiro Mihara³, Kazuyoshi Yanagihara⁴, Toshio Seyama¹ (1. Fac. Pharm., Yasuda Women’s Univ, 2. Sch. Pharm. Sci., Ohu Univ., 3. Fujita Health Univ., 4. Nat. Can. Cen.)

3:14 PM - 3:26 PM

[26E2-pm08] Effectiveness evaluation of SHAPE-MaP analysis for antisense oligonucleotides design

○Yuuya Kasahara^1,2, Natsumi Kameoka¹, Harumi Yamaguma¹, Satoshi Obika^1,2,3 (1. NIBIOHN, 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. OTRI, Osaka Univ.)

3:26 PM - 3:38 PM

[26E2-pm09S] Design strategy for gapmer antisense oligonucleotides to improve antisense activity

○Chihiro Oda^1,2, Yuuya Kasahara^2,3, Harumi Yamaguma², Masahito Shimojo³, Satoshi Obika^2,3,4 (1. Sch. Pharm. Sci., Osaka Univ., 2. NIBIOHN, 3. Grad. Sch. Pharm. Sci., Osaka Univ., 4. OTRI, Osaka Univ.)

3:38 PM - 3:50 PM

[26E2-pm10] RNA recognition ability of ENA-containing 2'-O-methyl RNA and DNA

○Elisa Tomita-Sudo¹, Tomoka Akita², Ayumu Kashiwagi², Renshin Sano², Yoshiyuki Onishi³, Makoto Koizumi³, Junji Kawakami^1,2 (1. Konan Laboratory for Oligonucleotide Therapeutics, 2. FIRST, Konan Univ., 3. Modality Res. Lab., Daiichi Sankyo Co., Ltd.)

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