[26E4-pm] Synthesis 5 (Nucleic acids)

Sun. Mar 26, 2023 5:10 PM - 6:22 PM [Room E4] Institute for the Advancement of Higher Education: E311 (Bldg. E: 3F)

Chair: Yasufumi Fuchi, Yoshihiro Natori

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5:10 PM - 5:22 PM

[26E4-pm16S] Development of a novel chemical phosphorylation reagent for artificial mRNA preparation

○Mami Ototake¹, Kaoru Onda¹, Masahito Inagaki¹, Naoko Abe¹, Fumitaka Hashiya², Yasuaki Kimura¹, Hiroshi Abe^1,2,3,4 (1. Grad. Sch. Sci.,nagoya Univ, 2. Research Center for Materials Science, 3. JST-CREST, 4. iGCORE)

5:22 PM - 5:34 PM

[26E4-pm17S] Syntheses of pseudo-complementary SNA/L-aTNA and destabilization of homo-duplexes

○Fuminori Sato¹, Yukiko Kamiya¹, Hiroyuki Asanuma¹ (1. Grad. Sch. Eng., Nagoya Univ.)

5:34 PM - 5:46 PM

[26E4-pm18S] Development of LNA-phosphoramidites to improve the elongation efficiency in oligonucleotide synthesis

○Ayaka Ichikawa¹, Takashi Osawa², Satoshi Obika^2,3,4 (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. NIBIOHN, 4. OTRI)

5:46 PM - 5:58 PM

[26E4-pm19S] Post-synthetic nucleobase modification of oligonuceotides by Sonogashira reaction and the effects on duplex stability

○Atsushi Mikami¹, Shohei Mori¹, Takashi Osawa¹, Satoshi Obika^1,2,3 (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. NIBIOHN, 3. OTRI)

5:58 PM - 6:10 PM

[26E4-pm20S] Synthesis of Guanine Derivative of 2'-O,4'-C-Spirocyclopentylene-Bridged Nucleic Acid

○Riku Kumagai¹, Takaya Sugiura², Hibiki Komine², Takao Yamaguchi², Satoshi Obika^2,3,4 (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. NIBIOHN, 4. OTRI)

6:10 PM - 6:22 PM

[26E4-pm21S] Synthesis and Properties of 2′-O-methyl-5-methyluridine Derivative bearing a 1–Oxaspiro[4.5]decane Skeleton

○Sayoko Ito¹, Natsumi Yano², Takashi Osawa², Satoshi Obika^2,3,4 (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. NIBIOHN, 4. OTRI)

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