Oral Presentation

[26F2-am] Evaluation of drug efficacy and safety 1/Endocrine and metabolic systems 1/Kampo medicines

Sun. Mar 26, 2023 9:00 AM - 10:24 AM [Room F2] Frontier Research in Applied Sciences Building: Seminar Room 1 (1F)

Chair: Kazuhiro Nishiyama, Shinya Dohgu

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9:00 AM - 9:12 AM

[26F2-am01S] Development of a stable cardiotoxicity evaluation method for analysis of beating iPS cell-derived cardiomyocytes

○Masanari Ban¹, Kenshiro Iwasita², Ayano Satsuka³, Yuta Imai¹, Kei Kanie⁴, Kazuho Sakamoto², Yasunari Kanda³, Junko Kurokawa², Ryuji Kato^1,5 (1. Grad. Sch. Pharm. Sci., Nagoya Univ. , 2. Sch. Pharm. Sci., Univ. Shizuoka, 3. NIHS, 4. Fac. Eng., Kindai Univ. , 5. Inst. Nano-Life-Systems, Nagoya Univ. )

9:12 AM - 9:24 AM

[26F2-am02S] Identification and evaluation of a compound that specifically inhibits oxidative modification of IRE1α

○Haruna Kurogi¹, Kam Y.J. Zhang², Takumi Abe¹, Daisuke Sawada¹, Takashi Uehara¹ (1. Grad. Sch. Med. Den. Pharm. Sci., Okayama Univ., 2. RIKEN Center for Biosystems Dynamics Research. )

9:24 AM - 9:36 AM

[26F2-am03S] Establishment of a hepatotoxicity evaluation system using UGT1A1-knockout human iPS cell-derived hepatic organoids

○Chiharu Imamura¹, Tomohiro Shintani², Yukiko Ueyama-Toba^1,2,3,4, Jumpei Inui², Hiroyuki Mizuguchi^1,2,3,4,5,6 (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., Osaka Univ., 3. NIBIOHN, 4. OTRI, Osaka Univ., 5. MEI center, Osaka Univ., 6. CiDER, Osaka Univ.)

9:36 AM - 9:48 AM

[26F2-am04S] Establishment of hyperoxic culture system for evaluation of drug-induced hepatic steatosis using hepatocytes isolated from chimeric mice with humanized liver

○Yuya Ohtsuki¹, Seigo Sanoh^1,2, Mikaru Yamao³, Yuha Kojima³, Yaichiro Kotake¹, Chise Tateno^2,3 (1. Grad. Sch. Biomed. Health Sci., Hiroshima Univ., 2. Sch. Pharm. Sci., Wakayama Med. Univ., 3. PhoenixBio Co., Ltd.)

9:48 AM - 10:00 AM

[26F2-am05S] Study of Anti-Fibrosis Effect of Lysophosphatidylserine Derivatives

○Luying Chen¹, Yuko Otani¹, Taketomo Kido², Tomohiko Ohwada¹, Atsushi Miyajima² (1. Grad. Sch. Pharm. Sci., Univ. of Tokyo, 2. IQB, Univ. of Tokyo)

10:00 AM - 10:12 AM

[26F2-am06S] Suppressive effects of melinjo seed extract (MSE) on high-fat diet-induced obesity in mouse model

○Tomoki Kishimoto¹, Aoi Nasu^1,2, Taisei Kawakami¹, Hirofumi Nohara^1,2, Noriki Takahashi^1,2, Megumi Hayashi¹, Choyo Ogasawara¹, Ayami Fukuyama¹, Kentaro Oniki³, Jyunji Saruwatari³, Tomoki Ikuta⁴, Marry Ann Suico¹, Hirofumi Kai¹, Tsuyoshi Shuto¹ (1. Dept. Mol. Med., Grad.Sch.Pharm.Sci.,Kumamoto Univ., 2. HIGO program., Grad. Sch. Kumamoto Univ., 3. Dept.Pharmacol. Ther., Grad.Sch.Pharm.Sci.,Kumamoto Univ., 4. Yamada Bee Company, Inc., R&D department)

10:12 AM - 10:24 AM

[26F2-am07] Metallothionein induction via Ninjin-yoei-to, a Japanese herbal medicine, and β-adrenergic receptor activation prevents hippocampal neurodegeneration after exposure to amyloid β₄₂

○Haruna Tamano^1,2, Haruna Tokoro², Daichi Murakami², Yuya Kawano², Rin Tsujimoto², Yuka Nishijima², Erina Tsuda², Satoshi Watanabe², Miki Suzuki², Atsushi Takeda² (1. Shizuoka Tohto Med. College, 2. Sch. Pharm Sci., Univ. Shizuoka)

Session information

[26F2-am] Evaluation of drug efficacy and safety 1/Endocrine and metabolic systems 1/Kampo medicines

[26F2-am01S] Development of a stable cardiotoxicity evaluation method for analysis of beating iPS cell-derived cardiomyocytes

[26F2-am02S] Identification and evaluation of a compound that specifically inhibits oxidative modification of IRE1α

[26F2-am03S] Establishment of a hepatotoxicity evaluation system using UGT1A1-knockout human iPS cell-derived hepatic organoids

[26F2-am04S] Establishment of hyperoxic culture system for evaluation of drug-induced hepatic steatosis using hepatocytes isolated from chimeric mice with humanized liver

[26F2-am05S] Study of Anti-Fibrosis Effect of Lysophosphatidylserine Derivatives

[26F2-am06S] Suppressive effects of melinjo seed extract (MSE) on high-fat diet-induced obesity in mouse model

[26F2-am07] Metallothionein induction via Ninjin-yoei-to, a Japanese herbal medicine, and β-adrenergic receptor activation prevents hippocampal neurodegeneration after exposure to amyloid β₄₂

Authentication

Session information

[26F2-am] Evaluation of drug efficacy and safety 1/Endocrine and metabolic systems 1/Kampo medicines

[26F2-am01S] Development of a stable cardiotoxicity evaluation method for analysis of beating iPS cell-derived cardiomyocytes

[26F2-am02S] Identification and evaluation of a compound that specifically inhibits oxidative modification of IRE1α

[26F2-am03S] Establishment of a hepatotoxicity evaluation system using UGT1A1-knockout human iPS cell-derived hepatic organoids

[26F2-am04S] Establishment of hyperoxic culture system for evaluation of drug-induced hepatic steatosis using hepatocytes isolated from chimeric mice with humanized liver

[26F2-am05S] Study of Anti-Fibrosis Effect of Lysophosphatidylserine Derivatives

[26F2-am06S] Suppressive effects of melinjo seed extract (MSE) on high-fat diet-induced obesity in mouse model

[26F2-am07] Metallothionein induction via Ninjin-yoei-to, a Japanese herbal medicine, and β-adrenergic receptor activation prevents hippocampal neurodegeneration after exposure to amyloid β42

Authentication

[26F2-am07] Metallothionein induction via Ninjin-yoei-to, a Japanese herbal medicine, and β-adrenergic receptor activation prevents hippocampal neurodegeneration after exposure to amyloid β₄₂