[S09] Innovative sulfur biology and its translational application emerging from supersulfides

Sun. Mar 26, 2023 10:10 AM - 12:10 PM [Room HS1] (1F)

Organizer: Motohiro Nishida, Hidehiko Nakagawa

Supersulfides, in which sulfur atoms are catenated, are abundantly present in our body as a universal life element and have been clarified to act as an important electron transfer conductor that supports energy metabolism, protein quality control, and signal transduction. Supersulfides are thought to sense oxygen and reactive oxygen species and are responsible for their biological activities. They also play a key role in the creation of physiological functions of major biomolecules such as nucleic acids and proteins, and support a wide range of biological phenomena. We will introduce cutting-edge technologies on quantitative sulfur omics, sulfur imaging, and chemical modulators necessary for elucidating the functional interactions between supersulfides and various related molecules and biological systems. We will discuss a multidisciplinary approach to building a consortium on global standards for sulfur metabolic flux. Furthermore, we will create innovative biology utilizing these technologies for measuring supersulfides, and renew the biological concept of physiological and pathological functions useful for human health care.

+Add all to schedule

オーガナイザー挨拶：西田基宏（九大院薬） (10:10 AM - 10:11 AM)

10:11 AM - 10:35 AM

[S09-01] Sulfur metabolism regulation and cytoprotection by NRF2

○Hozumi Motohashi¹ (1. IDAC, Tohoku Univ.)

10:35 AM - 10:59 AM

[S09-02] Supersulfide electron transfer mediates host defense and energy metabolism

○Takaaki Akaike¹ (1. Grad. Sch. Med., Tohoku Univ.)

10:59 AM - 11:23 AM

[S09-03] The radical-scavenging activity of super sulfide molecules and its role in intracellular signaling

○Yoshiro Saito¹ (1. Grad. Sch. Pharm., Tohoku Univ.)

11:23 AM - 11:47 AM

[S09-04] Development of fluorescent probes for supersulfides and their application to development of chemical tools for biosynthesis regulation of supersulfides

○Kenjiro Hanaoka¹ (1. Grad. Sch. of Pharm., Keio Univ.)

11:47 AM - 12:10 PM

[S09-05] Chemical tools for supersulfide formation and reactivity in biological milieu

○Hidehiko Nakagawa¹ (1. Grad. Sch. Pharm., Nagoya City Univ.)