Oral Presentation

[27C2-am] Nucleic acids 1

Mon. Mar 27, 2023 9:00 AM - 10:12 AM [Room C2] Institute for the Advancement of Higher Education: S5 (Bldg. S: 1F)

Chair: Hidetoshi Tahara, Tetsuya Suzuki

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9:00 AM - 9:12 AM

[27C2-am01S] Development of gapmer antisense oligonucleotide for transcriptional repressor REST that causes several malignant brain tumors

○Yusuke Tamenori¹, Satoshi Obika^2,3,4, Masahito Shimojo² (1. Sch. Pharm. Sci., Osaka Univ., 2. Grad. Sch. Pharm. Sci., 3. OTRI, Osaka Univ., 4. NIBIOHN)

9:12 AM - 9:24 AM

[27C2-am02S] Pharmacokinetics of the antisense oligonucleotide SRRM4-ASO for the treatment of small cell lung cancer

○Ryota Suginaka¹, Satoshi Obika^1,2,3, Masahito Shimojo¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ, 2. NIBIOHN, 3. OTRI)

9:24 AM - 9:36 AM

[27C2-am03S] Study of cellular uptake of antisense oligonucleotide using TRPC3/TRPC6 activator

○Hiroto Kohashi¹, Ryu Nagata¹, Satoshi Obika^1,2,3, Masahito Shimojo¹ (1. Grad. Sch. Pharm. Sci., Osaka Univ., 2. OTRI, Osaka Univ., 3. NIBIOHN)

9:36 AM - 9:48 AM

[27C2-am04] Comparison of binding affinity and binding rate to the target sequence for different modifications used in antisense nucleic acids

○Nae Sakimoto¹, Syuichiro Fujiki², Riki Hatanaka², Satoshi Obika^3,4,5, Junji Kawakami^1,2 (1. KOLOT, Konan Univ., 2. FIRST, Konan Univ., 3. Grad. Sch. Pharm. Sci., Osaka Univ., 4. OTRI, Osaka Univ., 5. NIBIOHIN)

9:48 AM - 10:00 AM

[27C2-am05S] Physicochemical alteration and positioning reorganization of nucleosome caused by platinum-based antineoplastics

○Xuanyu LIAO¹, Takafumi Furuhata¹, Akimitsu Okamoto¹ (1. Grad. Sch. Engineering., Tokyo University )

10:00 AM - 10:12 AM

[27C2-am06] Analysis of nucleotide incorporation and primer extension opposite a novel guanine oxidation damage by DNA polymerases.

○Taishu Kawada¹, Takanobu Kobayashi¹, Katsuhito Kino² (1. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 2. Department of Nano Material and Bio Engineering, Faculty of Science and Engineering, Tokushima Bunri University)

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