[27E1-am] Chemical biology/Drug design/Synthetic compounds in drug discovery

Mon. Mar 27, 2023 11:00 AM - 12:00 PM [Room E1] Institute for the Advancement of Higher Education: E301 (Bldg. E: 3F)

Chair: Shinichi Sato, Atsuhiko Taniguchi

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11:00 AM - 11:12 AM

[27E1-am11S] Expansion of histone acylation catalyst system using novel nucleosome ligands

○Mayu Onoda¹, Tamiko Nozaki¹, Kenzo Yamatsugu¹, Shigehiro Kawashima¹, Motomu Kanai¹ (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo)

11:12 AM - 11:24 AM

[27E1-am12S] In-cell artificial catalysis for anti-cancer transcriptional activation

○Yuki Yamanashi¹, Yuto Azumaya¹, Yugo R Kamimura¹, Atsushi Okabe², Atsushi Kaneda², Kenzo Yamatsugu¹, Shigehiro Kawashima¹, Motomu Kanai¹ (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Graduate School of Medicine, Chiba University)

11:24 AM - 11:36 AM

[27E1-am13S] A chemical catalyst enabling histone acylation with endogenous acyl-CoA

○Misuzu Habazaki¹, Kohei Watanabe¹, Ryo Takita², Shinsuke Mizumoto¹, Hidetoshi Kajino¹, Shigehiro Kawashima¹, Kenzo Yamatsugu¹, Motomu Kanai¹ (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. Grad. Sch. Pharm. Sci, Univ. of Shizuoka)

11:36 AM - 11:48 AM

[27E1-am14] Discovery of histone deacetylase inhibitors synthesizable in water-rich condition using gold-catalyzed amidation reaction

○Kosuke Hashimoto¹, Mayumi Arata², Akiko Nakata², Takashi Ito², Akihiro Ito³, Norio Kudo², Minoru Yoshida^2,4, Katsunori Tanaka^5,6, Yasuo Nagaoka¹, Takaaki Sumiyoshi¹ (1. Grad. Sch. Sci. Eng., Kansai Univ., 2. RIKEN CSRS, 3. Dept. Biotechnol., Tokyo Univ., 4. Sch. Life Sci., Tokyo Univ. Pharm. Life Sci., 5. School of Meterials and Chemical Technology, Tokyo Tech, 6. Cluster for Pioneering Research, RIKEN)

11:48 AM - 12:00 PM

[27E1-am15S] Drug discovery research on KDM5B inhibitors for improvement of their cellular activity

○Mitsuhiro Terao¹, Yasunobu Yamashita¹, Yuri Takada¹, Yukihiro Itoh¹, Takayoshi Suzuki¹ (1. SANKEN)

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