[27P2-am1-028S] Effects of β₂ adrenoceptor agonists-induced positive chronotropy and pharmacological study for species difference of procaterol

○Rikako Kobayashi¹, Nana Kashimoto¹, Sakiko Sonobe¹, Haruna Kanae¹, Kazuo Noguchi¹ (1. Sch. Pharm. Sci., Mukogawa Women's Univ.)

[27P2-am1-029S] Role of indigo leaf components in the development of pulmonary arterial hypertension

○Honoka Tsunematsu¹, Yuka Uemura¹, Yoshiya Higaki¹, Miyu Morisaki¹, Akari Katsura¹, Richit Miyamoto², Koichi Tsuneyama³, Masaki Imanishi¹, Koichiro Tsuchiya¹ (1. Dept. Med. Pharmacol., Tokushima Univ. Grad. Sch., 2. Lab. Pharmacol. and Food Sci., Dept. Nutr. and Life Sci. Kanagawa Inst. of Tech., 3. Dept. Pathol. and Lab. Med., Tokushima Univ. Grad. Sch.)

[27P2-am1-030S] Effects of Suramin administration on ST-elevation and H-FABP and Connexin-40 protein levels of myocardial tissue in anaphylaxis-induced rats

○Yuka Satake¹, Norihito Kado¹, Katsuya Nakata¹, Koki Shimizu¹, Seiichiro Kano¹ (1. Hokkaido University of Science)

[27P2-am1-031S] Nalmefene, a reducing alcohol consumption drug, enhances oxLDL uptake in macrophages and aggravates atherosclerotic lesion through increasing expression of CD36 scavenger receptor.

○Ayano Yamada^1,2, Mitsuhisa Koga¹, Koshun Inada³, Atsushi Yamauchi³ (1. Depart. Drug Delivery, Fac. Pharmaceut. Sci., Fukuoka Univ. , 2. Depart. Formulation Design, Grad. Sch. of Pharmaceut. Sci.,Fukuoka Univ., 3. Depart. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ. )

[27P2-am1-032S] Geniposidic acid, a component from Eucommia leaves, improves hypoxia-induced pulmonary hypertension.

○Wakana Tani¹, Mari Hida¹, Takuya Matsubara¹, Hideaki Tagashira², Tomo Kita², Takayuki Nemoto², Tetsuya Hirata³, Takahiro Iwamoto², Satomi Kita^1,2 (1. Dept. Pharmacol., Facul. Pharmaceu. Sci., Tokushima Bunri Univ., 2. Dept. Pharmacol., Facul. Med., Fukuoka Univ. , 3. R&D Ctr, Kobayashi Pharmaceut. Co., Ltd.)

[27P2-am1-033S] Moxifloxacin, a fluoroquinolone antibiotic, developments and exacerbates aortic aneurysm and dissection by increasing expression of osteopontin in macrophages

○Koshun Inada¹, Mitsuhisa Koga², Ayano Yamada², Atsushi Yamauchi³ (1. Dept. Pharmaceut. Care & Health Sci., Grad. Sch. of Pharmaceut. Sci., Fukuoka Univ., 2. Dept. Drug Delivery, Fac. Pharmaceut. Sci., Fukuoka Univ., 3. Dept. Pharmaceut. Care & Health Sci., Fac. Pharmaceut. Sci., Fukuoka Univ.)

[27P2-am1-034S] Different Responses to the Mouse Model of Heart Failure with Preserved Ejection Fraction by Age and Gender

○Hyeree Kim^1,2, Kiho Harada¹, Fujimi Kudo², Hiroyuki Takano¹, Ichiro Manabe² (1. Grad. Sch. Pharm. Sci., Chiba Univ, 2. Grad. Sch. Med., Chiba Univ)

[27P2-am1-035] Repressive effects of nobiletin against the changes in the levels of blood coagulation markers in the LPS-induced rat DIC model

○Kimihiko Takada¹, Mayuko Takano¹, Aiko Kunii¹, Kei Harayama¹, Yoshiko Miyazaki¹, Yutaka Masuda² (1. Commun. Medicine, Showa Pharm. Univ., 2. Appl. Therapeut., Showa Pharm. Univ.)

[27P2-am1-036] Effect of Tie-2 activation by Eleutherococcus senticosus

○Kazutaka Atobe¹, Shizuo Yamada², Yoshihisa Kato¹ (1. Kagawa Sch. Pharm. Sci., Tokushima Bunri Univ., 2. Ctr. Pharma-Food Res., Grad. Sch. Integr. Pharm. Nutr. Sci., Univ. Shizuoka)

[27P2-am1-037] Nitric oxide-soluble guanylyl cyclase-cyclic GMP pathway involves in the vasorelaxant effects of benzodiazepines and non-benzodiazepine drugs

Risa Futokoro¹, Kana Maruyama Fumoto¹, Junko Chimoto³, Shizuo Yamada³, Kazumasa Shinozuka¹, ○Satomi Kagota^1,2 (1. Dept. Pharmacol. II, Sch. Pharm. and Pharmaceu. Sci., Mukogawa Women's Univ., 2. Ins. Bio. Mukogawa Women's Univ., 3. Centr. for Pharm-Food Res, Univ. of Shizuoka.)

[27P2-am1-038] Comparison of contractile properties by three-dimensional heart tissue using two types of human iPS cell-derived cardiomyocytes

○Daiju Yamazaki¹, Shinichiro Horiuchi¹, Nanae Koda¹ (1. Div. Pharmacol., NIHS)

[27P2-am1-039S] Assessment of drug-induced chronic cardiotoxicity using human iPS cells- derived cardiomyocytes.

○Shota Yanagida^1,2, Ayano Satsuka¹, Sayo Hayashi¹, Atsushi Ono², Yasunari Kanda^1,2 (1. NIHS, 2. Grad. Sch. Pharm. Sci, Okayama UniV.)

[27P2-am1-040] Neurotoxicity evaluation of dissociative anesthetics using human iPS cell-derived neurons

○Yukuto Yasuhiko¹, Shigeru Yamada¹, Ruri Hanajiri², Yasunari Kanda¹ (1. Division of Pharmacology, NIHS, 2. Division of Pharmacognosy and Phytochemistry, NIHS)

[27P2-am1-041] Identification of kynurenine and qunolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases

○Yuchen Sun¹, Kosuke Saito¹, Ushiki Atsuhito², Mitsuhiro Abe³, Yhoshinobu Saito⁴, Takeru Kashiwada⁴, Yasushi Horimasu⁵, Akihiko Gemma⁴, Koichiro Tatsumi³, Noboru Hattori⁵, Kenji Tsushima⁶, Noriaki Arakawa¹, Hirotoshi Akane⁷, Takeshi Toyoda⁷, Kumiko Ogawa⁷, Motonobu Sato⁸, Kazuhiko Takamatsu⁸, Kazuhiko Mori⁹, Takayoshi Nishiya⁹, Takashi Izumi¹⁰, Yasuo Ohno¹⁰, Yoshiro Saito¹, Masayuki Hanaoka² (1. Div. Medicinal Safety Science, NIHS, 2. Shinshu Univ. Med., 3. Grad. Sch. Med., Chiba Univ., 4. Grad. Sch. Med., Nippon Med. Sch., 5. Hiroshima Univ. Hosp., 6. nternational Univ. Health and Welfare, 7. Div. Path., NIHS, 8. Astellas Pharma Inc., 9. Daiichi Sankyo RD Novare Co., Ltd. , 10. Kihara Memorial Yokohama Foundation)

[27P2-am1-042] Evaluation of human tyrosinase-mediated metabolic activation of leukoderma-inducing phenols

○Tomoko Nishimaki-Mogami¹, Shosuke Ito², Hongyan Cui¹, Takumi Akiyama¹, Norimasa Tamehiro¹, Reiko Adachi¹, Kazumasa Wakamatsu², Yoshiaki Ikarashi¹, Kazunari Kondo¹ (1. Natl. Inst. Health Sci., 2. Inst. Melanin Chem., Fujita Health Univ.)

[27P2-am1-043S] Protective role of highly Ca²⁺-permeable TRPV6 in the pathogenesis of inflammatory bowel disease

○Mayu Takayama¹, Fuho Mori¹, Michiko Saito², Hiroyuki Yasuda¹, Kenjiro Matsumoto¹, Shinichi Kato¹ (1. Div. Pathol. Sci., Dept. Pharmacol. Exp. Ther., Kyoto Pharm. Univ., 2. Bio-Sci. Res. Ctr., Kyoto Pharm. Univ.)

[27P2-am1-044S] Immunolocalization of molecular chaperone Osp94 in gastrointestinal Neuropod cells

○Asahi Kanno¹, Honomi Shirasuna¹, Ryoji Kojima¹ (1. Meijo University)

[27P2-am1-045] Green tea extract prevents CPT-11-induced delayed diarrhea by regulating UGT1A1 in rat colon

○Risako Kon¹, Rei Tomimoto¹, Yuka Teshima¹, Arisa Yamaguchi¹, Nobutomo Ikarashi¹, Hiroyasu Sakai¹, Tomoo Hosoe¹ (1. Hoshi Univ.)

[27P2-am1-046S] Regulation of bone resorption by lactate dehydrogenase A (LDHA) in osteoclast

○Sami Hiramatsu¹, Rumi Anzai¹, Ayaka Terazono¹, Mamiko Nakao¹, Miyu Moriyama¹, Tsuyoshi Nishioku¹ (1. Pharm. Sci.,Nagasaki International Univ.)

[27P2-am1-047S] MCT4-mediated extracellular secretion of lactate in osteoclasts

○Rumi Anzai¹, Sami Hiramatsu¹, Ayaka Terazono¹, Mamiko Nakao¹, Miyu Moriyama¹, Tsuyoshi Nishioku¹ (1. Pharm. Sci.,Nagasaki International Univ.)

[27P2-am1-048S] Effect of lactoferrin enteric-coated preparation on LPS-induced decreased bone density

○Takako Machida¹, Kai Suzuki¹, Kazari Mizoguchi¹, Ryoken Aoki¹, Megumi Furukawa¹, Megumi Ohno², Nobuo Izumo^1,3 (1. Yokohama University of Pharmacy, 2. NRL Pharma,Inc, 3. General Health Medical Research Center,Yokohama University of Pharmacy)

[27P2-am1-049] Skull abnormality in mitochondrial protein p13 knockout mice

○Masafumi Noguchi¹, Wakana Matsuo², Yu Usami³, Keiko Iwata¹, Satomi Hara², Hitoshi Hashimoto^2,4,5,6, Norihito Shintani^1,2 (1. Lab. of Pharmacol., Sch. of Pharmaceut. Sci., Wakayama Med. Univ., 2. Lab. Mol. Neuropharmacol., Grad. Sch. Pharmaceut. Sci., Osaka Univ., 3. Dept. of Oral Pathol., Osaka Univ. Grad. Sch. of Dentistry, 4. Mol. Res. Center for Children's Mental Devel., United Grad. Sch. of Child Devel., 5. Open and Transdiscipl. Res. Initiatives, Osaka Uni., 6. Div. of Biosci., Inst. for Datability Sci., Osaka Uni.)

Session information

[27P2-am1] Pharmacology 6