Graduate and Undergraduate Student Symposium

[GS02] Drug Discovery Research Pioneered by Young Researchers~Toward the Creation of Innovative Drugs~

Mon. Mar 27, 2023 1:50 PM - 3:50 PM [Room PS1] (1F)

Organizer: Motoharu Hirano, Ryotaro Notomi

Recently, drug discovery research on new modalities using macromolecules, and small and medium molecules has been actively conducted with the aim of creating innovative drugs. Among them, antibody drugs with target specificity and weaker side effects, nucleic acid drugs targeting DNA and RNA, and peptide drugs inhibiting protein-protein interactions, have many advantages over conventional small molecule drugs. However, the large molecular size and high polarity of these molecules make it difficult for them to penetrate into cell. In addition, they lack chemical stability in vivo and are easily degraded. Therefore, it is very important to develop techniques to deliver antibodies, nucleic acids, and peptides into cells and to modify molecules to improve their chemical stability.
This symposium will focus on antibodies, nucleic acids, and peptides as new modalities, and will introduce the research of graduate students who are energetically engaged in drug discovery research. We hope that this symposium will provide an opportunity for active discussions and lead to the creation of the next generation of drugs.

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オーガナイザー挨拶 (1:50 PM - 1:54 PM)

1:54 PM - 2:14 PM

[GS02-01] Encapsulation of antibodies in lipid nanoparticles for the targeting of intracellular proteins

○Yusuke Hirai¹ (1. Inst. Chem. Res., Kyoto Univ.)

2:14 PM - 2:37 PM

[GS02-02] Medicinal chemistry on the cyclic dinucleotide STING agonists with sulfur atoms in the furanose rings

○Aki Kondo¹, Mao Kinoshita¹, Noriko Tarashima¹, Noriaki Minakawa¹ (1. Tokushima Univ.)

2:37 PM - 3:00 PM

[GS02-03] Development of artificial nucleic acids that enable triplex DNA formation for methylated DNA involved in epigenetic regulation and its application research

○Ryotaro Notomi¹, Shigeki Sasaki², Yosuke Taniguchi¹ (1. Graduate School of Pharmaceutical Sciences, Kyushu Univ., 2. Faculty of Pharmaceutical Science, Nagasaki International Univ.)

3:00 PM - 3:23 PM

[GS02-04] Development and structural analysis of membrane-permeable cyclic peptides by cyclopropane-based conformational restriction strategy

○Yuki Yamazaki¹, Hiroyuki Kumeta², Kouhei Matsui¹, Koichi Fujiwara¹, Mizuki Watanabe¹, Satoshi Shuto¹ (1. Facul. Pharma. Sci., Hokkaido Univ., 2. Facul. Adv. Life Sci., Hokkaido Univ.)

3:23 PM - 3:46 PM

[GS02-05] Efficient intracellular delivery of pDNA, mRNA, and siRNA using amphiphilic stapled peptides

○Motoharu Hirano^1,2, Hidetomo Yokoo³, Makoto Oba³, Takashi Misawa², Yosuke Demizu^1,2 (1. Grad. Sch. Med, Life. Sci., Yokohama City Univ., 2. NIHS, 3. Kyoto Pref. Univ. Med.)

総括 (3:46 PM - 3:50 PM)

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