Oral Presentation

[28M2-pm] Drug metabolism

Tue. Mar 28, 2023 3:00 PM - 4:00 PM [Room M2] The Alumni Hall "Frate": Seminar Room (1F)

Chair: Taka-aki Koshimizu, Katsuya Narumi

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3:00 PM - 3:12 PM

[28M2-pm06S] Prediction of plasma concentrations of atorvastatin and carbamazepine in subjects harboring cytochrome P450 3A4/5 variants using pharmacokinetic modeling

○Tasuku Sato¹, Koichiro Adachi¹, Norie Murayama¹, Makiko Shimizu¹, Yoichi Tanaka², Yoshiro Saito², Hiroshi Yamazaki¹ (1. Showa Pharma Univ., 2. NIHS)

3:12 PM - 3:24 PM

[28M2-pm07S] Individual differences in dog cytochrome P450 3A-mediated oxidation activities toward typical human selective substrates

○Yutaro Noda¹, Norie Murayama¹, Saho Morikuni¹, Yasuhiro Uno², Hiroshi Yamazaki¹ (1. Showa Pharma Univ., 2. Kagoshima Univ.)

3:24 PM - 3:36 PM

[28M2-pm08S] A family study of compound variants of flavin-containing monooxygenase 3 by phenotyping

○Miaki Makiguchi¹, Makiko Shimizu¹, Erika Shimamura¹, Yuka Yokota¹, Mizuki Harano¹, Akane Yamamoto², Hiroshi Yamazaki¹ (1. Showa Pharma Univ., 2. Kobe City Medical Center General Hospital)

3:36 PM - 3:48 PM

[28M2-pm09S] Evaluation of the metabolic stability of a backbone-alanyl peptoid in liver microsome

○Hiroka Kobayashi¹, Jumpei Morimoto¹, Shinsuke Sando¹ (1. Grad. Sch. Eng., Univ. Tokyo)

3:48 PM - 4:00 PM

[28M2-pm10S] Basic investigations into the pharmacokinetic application of human intestinal organoids using cryopreserved human intestinal epithelial cells, a commercial material.

○Kentaro Okada^1,2, Tomoki Yamashita³, Jumpei Yokota^2,3, Tatsuya Inui^2,3, Wataru Kishimoto⁴, Hiroshi Nakase⁵, Mizugichi Hiroyuki^1,2,3,6,7,8 (1. Sch. Pharm. Sci, Osaka Univ., 2. NIBIOHN, 3. Grad. Sci. Pharm. Sci., Osaka Univ, 4. NBI Co. Ltd., 5. Sapporo Med Univ., 6. MEI cent, Osaka Univ., 7. OTRI, Osaka Univ., 8. CiDER, Osaka Univ.)

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