[2P-461] (2T10p-09)Role of ESCRT machinery in the clearance of aggregate-prone proteins associated with neurodegenerative diseases

^○Hasegawa Takafumi¹, Oosima Ryuji^1,2, Takeda Atsushi³, Tanaka Nobuyuki¹, Aoki Masashi¹ (1.Div. of Neurol., Dep. of Neurosci. & Sens. Org., Tohoku Univ. Grad. Sch. of Med., 2.Div. of Cancer Biol. & Therapeut., Miyagi Cancer Cent. Res. Inst., 3.Sendai Nishitaga Hosp.)

第87回日本生化学会大会 |Thu. Oct 16, 2014 2:00 PM - 3:00 PM

[2P-462] Molecular mechanism of zinc-induced IL-23 expression in microglia

^○Doi Takuya, Hara Hirokazu, Kamiya Tetsuro, Adachi Tetsuo (Lab. of Clin. Pharm. , Gifu Pharm. Univ.)

第87回日本生化学会大会 |Thu. Oct 16, 2014 3:00 PM - 4:00 PM

[2P-463] (2T10p-04)A2BP1, a casal gene of autism and mental retardation, plays an essential role in cortical development

^○Hamada Nanako, Ito Hidenori, Tabata Hidenori, Nagata Koh-ichi (Dep. of Mol. Neurobiol., Inst. for Develop. Res., Aichi Human Service Center)

第87回日本生化学会大会 |Thu. Oct 16, 2014 2:00 PM - 3:00 PM

[2P-464] Involvement of BHLHE40 in expression of a GPI-anchorless splice variant of the prion protein under hypoxic conditions.

^○Kikuchi Yutaka¹, Yusa Sei-ichi^1,2, Kubosaki Atsutaka¹, Terajima Jun¹, Kanayasu-Toyoda Toshie³, Yamaguchi Teruhide³ (1.Div. Microbiol., Nat'l. Inst. Health Sci., 2.Changshu Inst. Technol., 3.Div. Biol. Chem. Biologicals, Nat'l. Inst. Health Sci.)

第87回日本生化学会大会 |Thu. Oct 16, 2014 3:00 PM - 4:00 PM

[2P-465] (2T10p-02)Molecular mechanism of shifting the cleavage site of APP by BACE1

^○Kimura Ayano, Suzuki Toshiharu (Lab. of Neuro., Grad. Sch. of Pharm. Sci., Univ. of Hokkaido)

第87回日本生化学会大会 |Thu. Oct 16, 2014 2:00 PM - 3:00 PM

[2P-466] Lipid-peroxidation stress induces oligomeization and insolubilization of alpha-synuclein, and modulate proteolysis system in SH-SY5Y cells

^○Shamoto-Nagai Masayo¹, Hisaka Shinsuke², Osawa Toshihiko³, Naoi Makoto³, Motoyama Noboru¹, Manamiyama Makoto¹, Maruyama Wakako¹ (1.Dep. of Cognitive Brain Sci., NCGG, 2.Dept. of Pharmacognosy, Fac. of Pharm., Meijo Univ., 3.Dept. of Hlth. and Nutr. Fac. of Psycological & Physical Sci., Aichi Gakuin Univ.)

第87回日本生化学会大会 |Thu. Oct 16, 2014 3:00 PM - 4:00 PM

[2P-467] Amyloid β-protein (1-42, O-acyl isopeptide form) is an inherently monomeric equivalent of an aggregative amyloid β-protein (1-42)

^○Yoshiya Taku¹, Maruno Takahiro², Uemura Tsuyoshi¹, Kubo Shigeru¹, Kiso Yoshiaki³, Sohma Youhei⁴, Yoshizawa-Kumagaye Kumiko¹, Kobayashi Yuji², Nishiuchi Yuji^1,5 (1.Peptide Institute, Inc., 2.Grad. Sch. of Eng., Osaka Univ., 3.Dept. of Bio-Sci., Nagahama Inst. of Bio-Sci. and Tech., 4.Grad. Sch. of Pharm. Sci., The Univ. of Tokyo, 5.Grad. Sch. of Sci., Osaka Univ.)

第87回日本生化学会大会 |Thu. Oct 16, 2014 2:00 PM - 3:00 PM

[2P-468] Dysbindin-1, a schizophrenia-related protein, functionally interacts with HDAC3

^○Soma Mika, Wang Min, Ishiura Shoichi (Depa. of Life Sci., Grad. Sch. of Arts and Sci., The Univ. of Tokyo)

第87回日本生化学会大会 |Thu. Oct 16, 2014 3:00 PM - 4:00 PM

[2P-469] Analysis of biopterin and neopterin in cerebrospinal fluids of patients and asymptomatic carriers of PARK8 Parkinson's disease.

^○Watanabe Yuki¹, Kurosaki Hiroki¹, Arakawa Shinobu¹, Hasegawa Kazuko², Aasly Jan O.³, Ichinose Hiroshi¹ (1.Grad. Sch. of Biosci. and Biotech., Tokyo Tech., 2.NHO Sagamihara hospital, 3.St. Olav's University Hospital)

第87回日本生化学会大会 |Thu. Oct 16, 2014 2:00 PM - 3:00 PM

[2P-470] (2T10p-14)The early sleep deficits in Parkinson's disease model Drosophila

^○Ito kumpei^1,2, Suzuki Takahiro², Kawasaki Haruhisa², Ishida Norio^1,2 (1.Grad. Sch. of Life and Env., Tsukuba Univ., 2.Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology)

第87回日本生化学会大会 |Thu. Oct 16, 2014 3:00 PM - 4:00 PM