[2P-162] The mechanism by which the mitochondria-mediated NAD ⁺ synthesis system regulates lysosome

^○Mikako Yagi, Takeshi Uchiumi, Dongchon Kang (Depaetment of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University)

The 92nd Annual Meeting of JBS

[2P-163] SNAREs define targeting specificity of trafficking vesicles

^○Seiichi Koike^1,2, Reinhard Jahn¹ (1.Max Planck Institute for Biophysical Chemistry, Neurobiology, 2.The University of Tokyo, Graduate School of Medicine, Molecular biology)

The 92nd Annual Meeting of JBS

[2P-164] Regulation of intracellular clearance by 3'-phosphoinositide-specific phosphatase, myotubularin-related protein-4 (MTMR4).

^○Kazuaki Yoshioka¹, Quynh H. Pham¹, Sho Aki¹, Noriko Takuwa^1,2, Yoh Takuwa¹ (1.Department of Physiology, Kanazawa University Graduate of Medical Sciences, 2.Department of Health Sciences, Ishikawa Prefectural Nursing University)

The 92nd Annual Meeting of JBS

[2P-165] Mechanism of V-ATPase a3 isoform-mediated secretory lysosome trafficking

^○Naomi Matsumoto¹, Mizuki Sekiya¹, Kojiro Tohyama^2,3, Eri Ishiyama-Matsuura², Ge-Hong Sun-Wada⁴, Yoh Wada⁵, Masamitsu Futai¹, Mayumi Nakanishi-Matsui¹ (1.Sch. of Pharm., Iwate Med. Univ., 2.Inst. of Biomed. Sci., Iwate Med. Univ., 3.Sch. of Dent., Iwate Med. Univ., 4.Fac. of Pharm. Sci., Doshisha Women's Univ., 5.ISIR, Osaka Univ.)

The 92nd Annual Meeting of JBS

[2P-166] PI(4,5)P₂ in late endosomes controls the small GTPase Rab7

^○Takashi Baba^1,2, Daniel J Toth¹, Nivedita Sengupta¹, Yeun Ju Kim¹, Tamas Balla¹ (1.NICHD, National Institutes of Health, 2.Graduate School of Medicine, Akita University)

The 92nd Annual Meeting of JBS

[2P-167] Sequential phosphoinositide conversion is required for transforming growth factor β-induced receptor endocytosis and Smad2/3 activation in endothelial cells

^○Sho Aki¹, Kazuaki Yoshioka¹, Shahidul Islam¹, Noriko Takuwa^1,2, Yoh Takuwa¹ (1.Department of Physiology, Kanazawa University School of Medicine, 2.Department of health and Medical Sciences, Ishikawa Prefectural Nursing University)

The 92nd Annual Meeting of JBS

[2P-168] SeviL, a novel asialo-GM1-binding lectin from Mytilisepta virgate, is secreted by an unconventional secretion mechanism.

Tsunehiro Imamura¹, Yuki Fujii¹, Marco Gerdol², Yasuhiro Ozeki³, Kenischi Kamata³, Jeremy R.H. Tame³, ^○Hideaki Fujita¹ (1.Nagasaki International University, Faculty of Pharmaceutical Sciences, 2.University of Trieste, Department of Life Sciences, 3.Yokohama City University, Graduate School of NanoBio Sciences)

The 92nd Annual Meeting of JBS

[2P-169] Contribution of specific ESCRT subset on synthesis of exosomes

^○Kouki Maeda¹, Simon Goto¹, Chitose Oneyama², Eiji Morita¹ (1.Faculty of Agriculture and Life Science, Hirosaki University, 2.Division of Cancer Cell Regulation, Aichi Cancer Center Research Institute)

The 92nd Annual Meeting of JBS

[2P-170] Wide distribution of covalent-to-noncovalent evolution of the ATG12-ATG5 complex in eukaryotes

^○Euki Yazaki¹, Hirokazu Sakamoto¹, Tadaaki Uehara², Yuji Inagaki^3,4, Hayashi Yamamoto¹, Noboru Mizushima¹ (1.Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2.Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan, 3.Faculty of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan, 4.Center for Computational Sciences, University of Tsukuba, Ibaraki, Japan)

The 92nd Annual Meeting of JBS

[2P-171] Identification of the novel ER-phagy receptor TEX264 and visualization of autophagosome-ER contact

^○Haruka Chino¹, Tomohisa Hatta², Tohru Natsume², Noboru Mizushima¹ (1.Department of Biochemistry and Molecular Biology, Graduate School of 6 Medicine, The University of Tokyo, 2.Molecular Profiling Research Center for Drug Discovery (molprof), National 10 Institute of Advanced Industrial Science and Technology (AIST), Tokyo)

The 92nd Annual Meeting of JBS