[1P-262] CD271 (NGFR) is required for cell proliferation in squamous cell carcinoma.

^○Mai Mochizuki¹, Shinkichi Morita², Takayuki Imai², Kazunori Yamaguchi³, Kazuo Sugamura³, Keiichi Tamai¹ (1.Division of Cancer Stem Cell, Miyagi Cancer Center Research Institute, 2.Department of Head and Neck Surgery, Miyagi Cancer Center, 3.Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute)

The 92nd Annual Meeting of JBS

[1P-263] Regulation of glucose dependence and xCT expression by Akt/mTOR signaling pathway in glioblastoma cells

^○Itsuki Yamaguchi, Hironori Katoh (Molecular Neurobiology, Graduate School of Biostudies, Kyoto University)

The 92nd Annual Meeting of JBS

[1P-264] Rational drug development through a whole-animal platform

^○Masahiro Sonoshita (Div. Biomed Oncol, Hokkaido Univ Instit for Genet Med)

The 92nd Annual Meeting of JBS

[1P-265] The effect of MO2455 and its derivatives, a novel compound that induces the accumulation of poly (ADP-ribose), on cancer cells

^○Yuka Sasaki^1,2, Takae Onodera^1,2, Kenji Matsuno³, Takeji Takamura⁴, Kengo Inoue⁵, Tatsu Shimoyama⁶, Fumiaki Koizumi^1,6, Mitsuko Masutani^1,2,6 (1.Dept. Frontier Life Sci., Grad. Sch. Biomed. Sci., Nagasaki Univ., 2.Lab. Collaborative Res., Div. Cellular Signaling, Natl. Cancer Ctr. Res. Inst., 3.Faculty of Engineering, Kogakuin Univ., 4.Faculty of Engineering, Kanagawa Inst. of Tech., 5.Pharma Valley Center, 6.Div. Clin. Res. Support, Komagome Hosp.)

The 92nd Annual Meeting of JBS

[1P-266] Adaptation to acidic extracellular pH increases tumorigenicity

^○Yasumasa Kato¹, Atsuko Suzuki¹, Toyonobu Maeda¹, Koetsu Ogasawara² (1.Department of Oral Function & Molecular Biology, Ohu University School of Dentistry, 2.Department of Immunobiology, IDAC, Tohoku University)

The 92nd Annual Meeting of JBS

[1P-267] Mitochondrial dysfunction in renal cancer progression.

^○Shogo Ehata^1,2, Kosuke Miyakuni¹, Jun Nishida¹, Kohei Miyazono¹ (1.Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 2.Environmental Science Center, The University of Tokyo)

The 92nd Annual Meeting of JBS

[1P-268] Metagenomic and metabolomic analyses reveal dynamic shifts in gut microbiota along the adenoma-carcinoma sequence in colorectal cancer

^○Sayaka Mizutani^1,2, Shinichi Yachida^3,4, Hirotsugu Shiroma¹, Satoshi Shiba⁴, Takuji Yamada^1,5 (1.School of Life Science and Technology, Tokyo Institute of Technology, 2.Research Fellow of Japan Society for the Promotion of Science, 3.Department of Cancer Genome Informatics, Graduate School of Medicine/Faculty of Medicine, Osaka University, 4.Division of Cancer Genomics, National Cancer Center Research Institute, 5.PRESTO)

The 92nd Annual Meeting of JBS

[1P-269] Functional significance of mutant IDH1 and p16 in cartilage-forming tumors

^○Takeshi Kamakura^1,2, Yonghui Jin^1,3, Makoto Watanabe⁴, Takeshi Okamoto^3,5, Hiroyuki Yoshitomi^1,2,5, Junya Toguchida^1,2,5 (1.Dept. Tissue Regeneration, Inst. for Front. Life and Med.Sci., Kyoto Univ., 2.Dept. Cell Growth and Differentiation, CiRA, Kyoto Univ., 3.Inst. for Advancement of a Clin. and Transl. Sci., Kyoto Univ. Hosp., Kyoto Univ., 4.Life Sci. Res. Ctr., Shimadzu Corporation, 5.Dept. Orthopaedic Surgery, Grad.Sch. Med., Kyoto Univ.)

The 92nd Annual Meeting of JBS

[1P-270] Analysis of PKCλ dependent glycolytic regulation in ALDH1 positive breast cancer stem cells

^○Yuka Nozaki¹, Hitomi Motomura¹, Shoma Tamori¹, Onaga Chotaro¹, Shotaro Kanai¹, Keiko Sato², Yasushi Hara³, Ryo Abe³, Tatsuo Kawakami⁴, Shigeo Ohno^4,5, Kazunori Akimoto¹ (1.Pharm, Tokyo Univ. Sci., 2.Science and Technology, Tokyo Univ. Sci., 3.RIBS, Tokyo Univ. Sci., 4.Medical ProteoScope Co., Ltd., 5.Yokohama City Univ., Sch.of Med.)

The 92nd Annual Meeting of JBS

[1P-271] Epigenetic role in acute myeloid leukemia associated with chromosomal translocation 8;21

^○Takeshi Ueda¹, Akinori Kanai², Akiyoshi Komuro¹, Hisayuki Amano¹, Hitoshi Okada¹ (1.Department of Biochemistry, Kindai University Faculty of Medicine, 2.Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University)

The 92nd Annual Meeting of JBS