[1T14e-11(P-800)] The SGLT2 inhibitor Tofogliflozin prevents the progression of nonalcoholic steatohepatitis-associated liver tumors in a novel murine model

^○Naoki Yoshioka^1,2, Miyako Tanaka¹, Kozue Ochi¹, Akiko Watanabe¹, Michiko Itoh^3,4, Masatoshi Ishigami², Mitsuhiro Fujishiro², Takayoshi Suganami¹ (1.Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, 2.Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 3.Kanagawa Institute of Industrial Science and Technology, 4.Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 6:40 PM - 6:50 PM

[1T15e-01(P-946)] Novel aminocyclopropenone compound inhibits BRD4-driven NUP210 expression and attenuates cancer growth

^○Hiroya Kondo¹, Kenji Mishiro², Masaharu Hazawa^2,3,4, Yuki Iwashima⁴, Akiko Kobayashi², Kazuma Ogawa², Wong Richard^2,3,4 (1.Division of Transdisciplinary Sciences, Institute for Frontier Science Initiative, Kanazawa Univ., Japan, 2.Institute for Frontier Science Initiative, Kanazawa Univ., Japan, 3.WPI Nano Life Science Institute, Kanazawa univ., Japan, 4.Division of Life Science and Engineering, Institute for Science and Engineering, Kanazawa Univ., Japan)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:00 PM - 5:10 PM

[1T15e-02(P-952)] The inhibition mechanism of cancer cell proliferation by glycyrrhizin derivative targeting PGRMC1

^○Ikko Koike, Yasuaki Kabe, Makoto Suematsu (Department of Biochemistry, Keio University School of Medicine)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:10 PM - 5:20 PM

[1T15e-03(P-939)] A novel tetravalent peptide directly binds to APP to inhibit the production of Amyloid β in cells.

^○Waka Sato¹, Miho Takahashi¹, Hina Uchiyama², Takashi Saito³, Takaomi Saido⁴, Satoru Funamoto², Kiyotaka Nishikawa¹ (1.Doshisha University, Grad. School of Life and Medical Sciences, Molecular Life Sciences, 2.Doshisha University, Grad. School of Life and Medical Sciences, Neuropathology, 3.Nagoya City University, Grad.School of Medical Science, Department of Neurocognitive Science, 4.Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:20 PM - 5:30 PM

[1T15e-04(P-948)] Development of thermoresponsive functional biomaterials by multimerization of short elastin-like peptide (FPGVG)n analogs

^○Keitaro Suyama¹, Mika Mawatari², Iori Maeda³, Takeru Nose^1,2 (1.Faculty of Arts and Science, Kyushu University, 2.Department of Chemistry, Faculty and Graduate School of Science, Kyushu University, 3.Department of Physics and Information Technology, Kyushu Institute of Technology)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:30 PM - 5:40 PM

[1T15e-05(P-949)] Cell Penetrating and biological activities of daptomycin modified with polycationic peptides

^○Tomoya Ogura, Kaito Suzuki, Yamato Takeuchi, Kohei Kaneda, Chitose Maruyama, Yoshimitsu Hamano (Graduate School of Bioscience and Biotechnology, Fukui Prefectural University)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:40 PM - 5:50 PM

[1T15e-06(P-974)] Development of drug delivery system for poorly water-soluble anti-cancer drug paclitaxel using protein capsules with pancreatic cancer-targeting peptide

^○Kuniyoshi Abe, Kosuke Furuta, Takashi Inui (Grad. Sch. of Life & Envi. Sci., Osaka Pref. Univ.)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 5:50 PM - 6:00 PM

[1T15e-07(P-975)] Cell membrane-penetrating sequence of saporin toxin and its application for drug delivery system

^○Momoko Obuki¹, Miku Katayama¹, Kosuke Noguchi¹, Stefania Zuppone², Mayu Yamana³, Tomoka Takatani-Nakase^4,5, Masashi Ueda^3,6, Riccardo Vago^2,7, Shiroh Futaki⁸, Arwyn T. Jones⁹, Ikuhiko Nakase¹ (1.Graduate School of Science, Osaka Prefecture University, 2.IRCCS San Raffaele Hospital, 3.College of Pharmacy, Okayama University, 4.College of Pharmacy, Mukogawa Women University, 5.Institute for Biosciences, Mukogawa Women University, 6.Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, 7.University Vita-Salute San Raffaele, 8.Institute for Chemical Research, Kyoto University, 9.School of Pharmacy and Pharmaceutical Sciences, Cardiff University)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 6:00 PM - 6:10 PM

[1T15e-08(P-944)] Development of high throughput assay for inhibitor screening targeting biglycan, a tumor angiogenesis factor

^○Suguru Ishii¹, Nako Maishi², Takuya Tsumita², Hideki Takekawa², Yui Umeyama², Kyoko Hida², Hiroyuki Takeda¹ (1.Ehime univ, PROS, 2.Vascular Biol Mol Pathol, Hokkaido Univ Grad Sch Dent Med)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 6:10 PM - 6:20 PM

[1T15e-09(P-957)] Development of a core fucose-deficient cancer-specific anti-podocalyxin antibody (60-mG_2a-f) for pancreatic carcinoma

^○Mika K. Kaneko¹, Tomokazu Ohishi², Manabu Kawada², Yukinari Kato^1,3 (1.Dept. Antibody Drug Development, Tohoku University Grad. Sch. of Med., 2.Inst. of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Res. Foundation, 3.Dept. Molecular Pharmacology, Tohoku University Grad. Sch. of Med.)

The 94th Annual Meeting of JBS |Wed. Nov 3, 2021 6:20 PM - 6:30 PM