[2P-0167] Globally impaired ER-Golgi trafficking as a cellular pathogenesis of Pelizaeus-Merzbacher disease

○Heng Li¹, Yu-ichi Goto¹, Ken Inoue¹ (1.Dept. of Mental Retardation and Birth Defect Research, NCNP)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0168] The nuclear localization mechanism of fish Neu4 sialidase; The interaction of Low complexity sequence with the nuclear transport protein

○Akinobu Honda¹, Masaharu Komatsu^1,2, Kazuhiro Shiozaki ^1,2 (1.Unit. Grad. Sch. Agricult. Sci. Kagoshima Univ., 2.Fac. Fish, Kagoshima Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0169] The ubiquitin ligase RNF181 plays a pivotal role in sustaining the mammalian proteasome activity under proteasome impairment

○Shota Okuno¹, Eiichi Hashimoto¹, Shoshiro Hirayama¹, Hidetaka Kosako², Jun Hamazaki¹, Shigeo Murata¹ (1.Grad. Sch. of Pharm, Univ. of Tokyo, 2.Fujii Memorial Institute of Medical Sciences)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0170] Identification of factors modulating the clearance of aggregate-prone tau by genome-wide CRISPR screening

○Yusen Men¹, Shinpei Ao¹, Yasuyuki Sakurai¹, Shoshiro Hirayama¹, Shigeo Murata¹ (1.Grad. Sch. of Pharm, Univ. of Tokyo)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0171] Analysis of processing, transportation, and secretion of collagen using visualized type I procollagen

○Koji Moriya¹, Hiromi Morita², Takashi Minowa², Nobutaka Hanagata², Toshiaki Tanaka¹ (1.Dept. of Life Sci. Technol., Tokyo Tech. , 2.NIMS)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0172] ADAM17-mediated ectodomain shedding is dependent on the distance between cell surface and the cleavage site

○Munenosuke Seto¹, Rika Tanaka¹, Junichi Takagi², Kyoko Shirakabe¹ (1.Dept. of Biomed. Sci., Col. of Life Sci., Rits. Univ., 2.Inst. for Prot. Res.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0173] Importin Α proteins differentially localize in cytoplasm

○Noriko Shibazaki¹, kazuya Jibiki¹, Mina Okayasu¹, Noriko Yasuhara¹ (1.Col.of Hum.& Sci., Dept. of Biosci., Nihon Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0174] Regulation of PI(4)P level at the Golgi is important for Rab5-mediated endosomal trafficking.

○Shunsuke Fukuda¹, Kaito Aoshima¹, Tomoki Sano¹, Makoto Nagano¹, Junko Y. Toshima^1,2, Jiro Toshima¹ (1.Dept. of Bio. Sci. and Tech., Tokyo Univ. of Sci., 2.Sch. of Heal. Sci., Tokyo Univ . of Tech.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0175] In silico search for genes having differentially localized protein isoforms via alternative splicing and alternative translation initiation

○Kenichiro Imai¹, Kazunori D. Yamada² (1.Cell. Mol. Biotech, AIST, 2.Grad. Sch. of Info. Sci, Tohoku Univ.)

The 43rd Annual Meeting of the Molecular Biology Society of Japan

[2P-0176] Ubiquitin-specific protease TRE17/USP6 promotes cancer cell invasion through the regulation of plasma membrane protein recycling

○Yukino Ogura^1,2, Norihiko Ohbayashi¹, Atushi Kawaguchi², Yasunori Kanaho¹, Yuji Funakoshi^1,2 (1.Department of Physiological chemistry, Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba, 2.Department of Infection Biology,Faculty of Medicine and Graduate School of Comprehensive Human Sciences, University of Tsukuba)

The 43rd Annual Meeting of the Molecular Biology Society of Japan