[3P-055] Search for undiscovered protein functional sites based on the spatial distribution of disease-associated missense variants

Chie Motono^1,2, Atsushi Hijikata³, Takatsugu Hirokawa^4,5, ^○Kenichiro Imai¹ (1.Cell. Mol. Biotech., AIST, 2.CBBD-OIL, AIST, 3.Sch.Life Sci., Tokyo Univ. Pharm. Life Sci., 4.Faculty Med., Univ. of Tsukuba, 5.TMRC, Univ. of Tsukuba)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-056] Frontiers in the β-barrel membrane protein insertion.

^○Hironori Takeda (Div. of Biol. Sci., NAIST)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-057] A Novel Heme-based Gas Sensor Phosphodiesterase from Pathogenic Bacterium

^○Nao Aoyama¹, Miki Egashira¹, Kenichi Kitanishi², Motoyuki Shimonaka² (1.Dept. of Chem., Grad. Sch. of Sci., Tokyo Univ. of Sci., 2.Dept. of Chem., Fac. of Sci., Tokyo Univ. of Sci.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-058] Purification of a Gas Sensor Protein from Pathogenic Bacterium for X-ray Crystallography

^○Nao Aoyama¹, Miki Egashira¹, Kenichi Kitanishi², Motoyuki Shimonaka² (1.Dept. of Chem., Grad. Sch. of Sci., Tokyo Univ. of Sci., 2.Dept. of Chem., Fac. of Sci., Tokyo Univ. of Sci.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-059] Transport of Glutathione into the endoplasmic reticulum

^○Chika Tsutsumi¹, Ryosuke Tahara², Ryuta Sakamoto², Hiroki Watanabe¹, Kazuhiro Nagata³, Ryo Ushioda^4,2 (1.Dept. of Life. Sci., Grad. Sch., Kyoto Sangyo Univ., 2.Fac. of Life Sci., Kyoto Sangyo Univ., 3.JT Biohistory Res. Hall, 4.Inst. for Protein dynamics, Kyoto Sangyo Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-060] Dynamics of the HP1 Hinge Region with DNA Measured by Site-directed Spin Labeling-EPR Spectroscopy

^○Isao Suetake¹, Kazunobu Sato², Toru Kawakami³, Tomoaki Sugishita³, Risa Mutoh⁴, Yuichi Mishima³, Takeji Takui², Toshimichi Fujiwara³, Toshiki Takei³, Hironobu Hojo³, Makoto Miyata², Toshiaki Arata² (1.Grad. Sch. of Nutrition, Nakamura Gakuen Univ, 2.Grad. Sch. Sci, Osaka Metro. University, 3.IPR, Osaka Univ, 4.Dep. Biomole. Sci., Fac. Sci., Toho Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-061] Activation mechanism of endoplasmic reticulum stress sensor protein through redox regulation

^○Shouta Wada¹, Kazuhiro Nagata², Ryo Ushioda^3,1 (1.Life Sci. Major, Divi. of Life. Sci., Univ. of Kyoto Sangyo, 2.BRH, 3.Lab. of Protein Biogenesis, Univ. of Kyoto Sangyo)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-062] IN VITRO RECONSTITUTION REVEALS COOPERATIVE MECHANISMS OF ADAPTER PROTEIN-MEDIATED ACTIVATION OF PHOSPHOLIPASE C-GAMMA1

^○Wada Junya¹, Rathnayake Udumbara¹, Jenkins Lisa², Singh Avinash³, Mohammadi Moose³, Appella Ettore², Randazzo Paul¹, Samelson Lawrence¹ (1.LCMB, CCR, NCI, NIH, 2.LCB, CCR, NCI, NIH, 3.Dept. of Biochem. and Mol. Pharm., Sch. of Med., NYU Langone Health)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-063] Development of multivalent antibody–protein nanoblock complexes using isopeptide bond forming tag system

^○Satsuki Takahashi¹, Ryutaro Asano², Raizo Yamamoto¹, Masafumi Sakono³, Ryoichi Arai^1,4 (1.Dept. of Appl. Biol., Fac. of Textile Sci. and Tech., Shinshu Univ., 2.Dept. of Biotech. and Life Sci., Grad. Sch. of Eng., Tokyo Univ. of Agri. and Tech., 3.Dept. of Appl. Chem., Fac. of Eng., Univ. of Toyama, 4.Dept. of Biomol. Innov., Inst. for Biomed. Sci., Shinshu Univ.)

The 45th Annual Meeting of the Molecular Biology Society of Japan

[3P-064] Meta-functionalization: an ancestry-unrelated swap of residues in the Epidermal Growth Factor Receptor (EGFR) evolution after Teleost genome duplication.

^○Pascarelli Stefano, Laurino Paola (Okinawa Institute of Science and Technology)

The 45th Annual Meeting of the Molecular Biology Society of Japan