[2E01-04] Radiation Medicine 1

[2E04] Biological Effect of Hyperthermia in Combination with Radiation in Breast Cancer Cells

*Malvina Supper¹, Muhammad Jameel², Oiendrila B Debnath¹, Ravikiran Mahadevappa², Koichi Ito³, Kazuyuki Saito³, Hang Fai Kwok², Mitsuru Uesaka¹ (1. University of Tokyo, 2. University of Macau, 3. Chiba University)

Keywords:Hyperthermia, Breast carcinoma cells, Microstrip patch antenna, Fractional radiation

Combination of hyperthermia and radiation therapy for treating cancer cells has been a topic of research for decades. For radio-resistant cancer cells this combination can be promising. High temperature makes tumors sensitive to radiation dose, consequently the overall radiation dose can be reduced. The aim of this study is to design a non-invasive antenna to increase the temperature more than 42.5 degrees on superficial breast tumors and then apply low dose radiation and to see the biological changes henceforth. In this research, experiments were done in MCF-7 and MDA 231 breast cancer cells.