[P2-112] The Impact of Ketogenic Diet on Inflammation Markers and Atherosclerosis in Patients with Refractory Epilepsy
[Introduction]
Ketogenic diet (KD) is a high-fat, low carbohydrate, and adequate protein diet used for intractable childhood epilepsy. This study aimed to investigate the effects on inflammation markers and the atherosclerotic process, in a prospective cohort of children with refractory epilepsy.
[Methodology]
Patients were studied based on the following inclusion criteria: (1) patients with refractory epilepsy and (2) patients had been on the ketogenic diet for at least three months. The study protocol for inflammation includes : (1) uric acid, cytokines level including IL-1, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, TNF-α,MCP-1 and vascular damage marker including adhesion molecules: E selectin, ICAM-1, VCAM-1 (R& D system, USA), thrombomodulin, and tissue factor were analyzed at 3, 6, 12 months compared to the time before ketogenic diet administrated. (2) All patients received measurement of common carotid artery intima media thickness by B-mode ultrasonography every 6 months.
[Results]
Twenty-five patients were recruited for ketogenic diet treatment, and 12 (48%, mean age 6.1 ± 6.8 years, 7 males) kept for at least 3 month and 3 (3/12; 25%) continued for at least 6 months. Patients exhibited an increase in the level of uric acid at three months (3.83 ± 0.59 vs 5.93 ± 2.02, P=0.046) and the averaged level was steady afterwards. Other biochemistry data including cytokines level and vascular damage markers did not show any significant changes. Furthermore, no significant changes in common carotid artery intima media thickness was observed during ketogenic diet treatment.
[Conclusions]
Although administration of ketogenic diet caused short-term elevation of uric acid, the inflammation markers for a relatively longer period did not produce any significant changes in the patients. There was no evidence that ketogenic diet would accelerate the atherosclerotic process.
Ketogenic diet (KD) is a high-fat, low carbohydrate, and adequate protein diet used for intractable childhood epilepsy. This study aimed to investigate the effects on inflammation markers and the atherosclerotic process, in a prospective cohort of children with refractory epilepsy.
[Methodology]
Patients were studied based on the following inclusion criteria: (1) patients with refractory epilepsy and (2) patients had been on the ketogenic diet for at least three months. The study protocol for inflammation includes : (1) uric acid, cytokines level including IL-1, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17A, IL-22, TNF-α,MCP-1 and vascular damage marker including adhesion molecules: E selectin, ICAM-1, VCAM-1 (R& D system, USA), thrombomodulin, and tissue factor were analyzed at 3, 6, 12 months compared to the time before ketogenic diet administrated. (2) All patients received measurement of common carotid artery intima media thickness by B-mode ultrasonography every 6 months.
[Results]
Twenty-five patients were recruited for ketogenic diet treatment, and 12 (48%, mean age 6.1 ± 6.8 years, 7 males) kept for at least 3 month and 3 (3/12; 25%) continued for at least 6 months. Patients exhibited an increase in the level of uric acid at three months (3.83 ± 0.59 vs 5.93 ± 2.02, P=0.046) and the averaged level was steady afterwards. Other biochemistry data including cytokines level and vascular damage markers did not show any significant changes. Furthermore, no significant changes in common carotid artery intima media thickness was observed during ketogenic diet treatment.
[Conclusions]
Although administration of ketogenic diet caused short-term elevation of uric acid, the inflammation markers for a relatively longer period did not produce any significant changes in the patients. There was no evidence that ketogenic diet would accelerate the atherosclerotic process.