[P2-60] A population based study of microcephaly among cerebral palsy children in West China
[Objective] This study aims to determine the prevalence, clinical profiles and clinical associations of microcephaly among cerebral palsy children in West China.
[Methods] We recruited children age 0~18 years old (born between 1995 and 2013) with cerebral palsy through the China Disabled Persons’ Federation (CDPF) branch in Chengdu. The diagnosis of cerebral palsy was reevaluated and seven comorbidities were documented. The Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) were used to assess the motor function. The occipital-frontal circumference (OFC) was measured and converted to age and sex normalized Z score. The association between microcephaly and GMFCS levels, MACS levels, frequency and total number of comorbidities in each child was evaluated.
[Results] Microcephaly was detected in 35.2% of 421 cerebral palsy children. There was a female dominance (52.7%) and the mean age was 7.5yrs in microcephalic cerebral palsy children. Microcephalic children had significantly worse gross and manual motor function (p<0.001; p<0.001), and significantly higher frequencies of comorbidities including cognitive impairment, language disorder and epilepsy than those with normal OFC (p<0.001; p=0.005; p=0.001). Among cerebral palsy children with microcephaly, the OFC Z score correlated positively with GMFCS level (rs = 0.352; p < 0.001), but negatively associated with MACS level (rs = -0.171, p=0.003) and the number of comorbidities in each child (r=-0.232, p<0.001).
[Conclusion] Microcephaly is a common malformation in cerebral palsy and is significantly associated with more severe motor deficit, higher risks for cognitive impairment, language disorder and epilepsy, and heavier burden of comorbidities.
[Methods] We recruited children age 0~18 years old (born between 1995 and 2013) with cerebral palsy through the China Disabled Persons’ Federation (CDPF) branch in Chengdu. The diagnosis of cerebral palsy was reevaluated and seven comorbidities were documented. The Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) were used to assess the motor function. The occipital-frontal circumference (OFC) was measured and converted to age and sex normalized Z score. The association between microcephaly and GMFCS levels, MACS levels, frequency and total number of comorbidities in each child was evaluated.
[Results] Microcephaly was detected in 35.2% of 421 cerebral palsy children. There was a female dominance (52.7%) and the mean age was 7.5yrs in microcephalic cerebral palsy children. Microcephalic children had significantly worse gross and manual motor function (p<0.001; p<0.001), and significantly higher frequencies of comorbidities including cognitive impairment, language disorder and epilepsy than those with normal OFC (p<0.001; p=0.005; p=0.001). Among cerebral palsy children with microcephaly, the OFC Z score correlated positively with GMFCS level (rs = 0.352; p < 0.001), but negatively associated with MACS level (rs = -0.171, p=0.003) and the number of comorbidities in each child (r=-0.232, p<0.001).
[Conclusion] Microcephaly is a common malformation in cerebral palsy and is significantly associated with more severe motor deficit, higher risks for cognitive impairment, language disorder and epilepsy, and heavier burden of comorbidities.