[P3-120] Reliability and validity of the Thai version of the Pediatric Quality of Life inventoryTM 3.0 Duchenne Muscular Dystrophy module in Thai children with Duchenne Muscular Dystrophy
[Introduction]
PedsQLTM 3.0 DMD Module is disease-specific designed to assess quality of life of children with DMD. The study aimed to evaluate the reliability and validity of the Thai version of Pediatric Quality of Life InventoryTM (PedsQLTM) 3.0 DMD Module in Thai children aged 5-18 years with DMD.
[Methodology]
The translation process is permitted by the inventor's approval (Dr. James Varni). Thai translation of the PedsQLTM 3.0 Duchenne Muscular Dystrophy Module was performed according to linguistic translation guidelines with the process of forward-backward translation. The Thai version scale was administered to children with DMD and their parents at neuromuscular clinic at Siriraj Hospital and the annual meeting of DMD day. The psychometric properties were established. The re-test was performed within 2-4 weeks.
[Results]
Twenty-three children were enrolled. An acceptable level of internal consistency for reliability was achieved which measured by α > 0.7 (total score: child α = 0.92, parent α = 0.94). Test-retest reliability showed substantial good agreement with intraclass correlation coefficients (ICCs) for total score: child report ICCs = 0.69 and parent report ICCs = 0.87 (P<0.001). Mean total scale score of PedsQLTM in ambulate and un-ambulate DMD children are 60 and 44 (P=0.09) by child self-report and 59 and 40 (P=0.04) by parent proxy-report. Child self-report score is in excellent agreement with the parent proxy-report scores (ICC=0.85, P<0.001)
[Conclusions]
PedsQLTM 3.0 DMD Module Thai version has acceptable reliability and validity. It is reliable measure of disease specific health-related quality of life in Thai children with Duchenne Muscular Dystrophy.
PedsQLTM 3.0 DMD Module is disease-specific designed to assess quality of life of children with DMD. The study aimed to evaluate the reliability and validity of the Thai version of Pediatric Quality of Life InventoryTM (PedsQLTM) 3.0 DMD Module in Thai children aged 5-18 years with DMD.
[Methodology]
The translation process is permitted by the inventor's approval (Dr. James Varni). Thai translation of the PedsQLTM 3.0 Duchenne Muscular Dystrophy Module was performed according to linguistic translation guidelines with the process of forward-backward translation. The Thai version scale was administered to children with DMD and their parents at neuromuscular clinic at Siriraj Hospital and the annual meeting of DMD day. The psychometric properties were established. The re-test was performed within 2-4 weeks.
[Results]
Twenty-three children were enrolled. An acceptable level of internal consistency for reliability was achieved which measured by α > 0.7 (total score: child α = 0.92, parent α = 0.94). Test-retest reliability showed substantial good agreement with intraclass correlation coefficients (ICCs) for total score: child report ICCs = 0.69 and parent report ICCs = 0.87 (P<0.001). Mean total scale score of PedsQLTM in ambulate and un-ambulate DMD children are 60 and 44 (P=0.09) by child self-report and 59 and 40 (P=0.04) by parent proxy-report. Child self-report score is in excellent agreement with the parent proxy-report scores (ICC=0.85, P<0.001)
[Conclusions]
PedsQLTM 3.0 DMD Module Thai version has acceptable reliability and validity. It is reliable measure of disease specific health-related quality of life in Thai children with Duchenne Muscular Dystrophy.