[P3-2] Relationship between Sleep EEG Power Spectrum and Executive Function in Children with Attention Deficit Hyperactivity Disorder
[Introduction] Many studies have disclosed more theta/beta ratio in power spectral analysis of awaking electroencephalogram (EEG) in children with Attention Deficit Hyperactivity Disorder (ADHD) than typical development children (TDC). However there are few studies about power spectrum in sleep EEG in ADHD. So we aimed to clarify the relationship between power spectrum in sleep EEG and executive function in ADHD children.
[Methods] Subjects were 18 patients with ADHD (mean age 8.74±1.54 years) and 18 typical development children (TDCs) (9.55±1.58 years). Behavioral performances were assessed by each mother using ADHD-Rating scale (SNAP-IV), Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS). Neuropsychological tests included Raven's Colored Progressive Materices (RCPM), Stroop test of Das-Naglieri Cognitive Assessment System (DN-CAS), Mogras as cognitive performance test (CPT). Current analyses focused on sleep spindle frequencies (12-14Hz) in stage 2 sleep and a power spectral analysis was performed using fast fourier transform (FFT) techniques.
[Results] Rating of both SNAP and PARS scores was higher in ADHD children. Neuropsychological tests also revealed abnormal findings in ADHD. Sleep EEG showed dominant distribution of 12Hz spindles in frontal area (Fp1, Fp2, F3, F4), but 14Hz spindles were distributed in central area. In power spectral analysis, occurrence ratio of frontal spindle powers of 12Hz was higher in ADHD patients than TDCs, especially ADHD with autism spectrum disorder (ASD). There was a significant correlation between occurrence ratio of 12Hz spindles and variability of reaction time of CPT.
[Conclusions] Spindle-frequency EEG activity might have positive association with sustained attention function in ADHD children.
[Methods] Subjects were 18 patients with ADHD (mean age 8.74±1.54 years) and 18 typical development children (TDCs) (9.55±1.58 years). Behavioral performances were assessed by each mother using ADHD-Rating scale (SNAP-IV), Pervasive Developmental Disorders Autism Society Japan Rating Scale (PARS). Neuropsychological tests included Raven's Colored Progressive Materices (RCPM), Stroop test of Das-Naglieri Cognitive Assessment System (DN-CAS), Mogras as cognitive performance test (CPT). Current analyses focused on sleep spindle frequencies (12-14Hz) in stage 2 sleep and a power spectral analysis was performed using fast fourier transform (FFT) techniques.
[Results] Rating of both SNAP and PARS scores was higher in ADHD children. Neuropsychological tests also revealed abnormal findings in ADHD. Sleep EEG showed dominant distribution of 12Hz spindles in frontal area (Fp1, Fp2, F3, F4), but 14Hz spindles were distributed in central area. In power spectral analysis, occurrence ratio of frontal spindle powers of 12Hz was higher in ADHD patients than TDCs, especially ADHD with autism spectrum disorder (ASD). There was a significant correlation between occurrence ratio of 12Hz spindles and variability of reaction time of CPT.
[Conclusions] Spindle-frequency EEG activity might have positive association with sustained attention function in ADHD children.