[P3-3] Characteristics of Attention and Inhibition in Epileptic Children with ADHD: An Event-Related Potential Study
[Introduction] Children with epilepsy often exhibit behavioral problems such as inattention and/or hyperactivity. However, pathophysiological difference with attention deficit hyperactivity disorder (ADHD) remains to be elucidated. It is known that event-related potentials (ERPs) in Go/NoGo task could reflect frontal inhibitory function in children. In this study, we examined attention and inhibition functions using ERPs and neuropsychological tasks in epileptic children with ADHD. We also evaluated the utility of ERPs in Go/NoGo task as a biomarker of inhibition function.
[Methodology] Subjects were 3 ADHD patients (mean age; 10.6 years), 3 epileptic children with ADHD (9.3 years), and 5 typically developing children (TDC; 10.0 years). Neuropsychological tasks included Raven's Colored Progressive Materices (RCPM) as perceptive intelligence, Stroop test of Das-Naglieri Cognitive Assessment System (DN-CAS) as executive function, Mogras test with cognitive performance test (CPT) as attention function. ERPs were recorded at Fz, Cz, Pz (10-20 method) during visual Go/NoGo tasks, which consisted of five colored stimulus with CPT.
[Results] In epileptic children with ADHD, RCPM score and accuracy rate in CPT were the significantly lowest, and both the omission and commission error with NoGo task were the highest. ERP data revealed delay of NoGo-P3 and Go-P3 latency, and decreased rate of NoGo-P3/Go-P3 amplitude in order of epileptic children with ADHD, ADHD only, and TDC.
[Conclusions] These results suggest that dysfunction of both attention and inhibition in the epileptic children with ADHD were more enhanced than ADHD patients. The rate of NoGo-P3/Go-P3 amplitude might be useful as a biomarker of inhibition function.
[Methodology] Subjects were 3 ADHD patients (mean age; 10.6 years), 3 epileptic children with ADHD (9.3 years), and 5 typically developing children (TDC; 10.0 years). Neuropsychological tasks included Raven's Colored Progressive Materices (RCPM) as perceptive intelligence, Stroop test of Das-Naglieri Cognitive Assessment System (DN-CAS) as executive function, Mogras test with cognitive performance test (CPT) as attention function. ERPs were recorded at Fz, Cz, Pz (10-20 method) during visual Go/NoGo tasks, which consisted of five colored stimulus with CPT.
[Results] In epileptic children with ADHD, RCPM score and accuracy rate in CPT were the significantly lowest, and both the omission and commission error with NoGo task were the highest. ERP data revealed delay of NoGo-P3 and Go-P3 latency, and decreased rate of NoGo-P3/Go-P3 amplitude in order of epileptic children with ADHD, ADHD only, and TDC.
[Conclusions] These results suggest that dysfunction of both attention and inhibition in the epileptic children with ADHD were more enhanced than ADHD patients. The rate of NoGo-P3/Go-P3 amplitude might be useful as a biomarker of inhibition function.