[P3-33] Impact of thyrotropin-releasing hormone treatment on recovery from cognitive, verbal and motor dysfunction after encephalopathy: a case report
Thyrotropin releasing hormone (TRH) has been known to improve neurological recovery from disturbance of consciousness, spinocerebellar degeneration, intractable epilepsy and traumatic injury, as well as to stimulate of the release of thyrotropin and prolactin from the anterior pituitary. Recoveries from some neurological sequelae after encephalopathy and encephalitis have been reported, but the long term outcome has remained unclear. We delivered TRH treatment to a boy who had cognitive, verbal and motor dysfunction after acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) with human herpesvirus 6 infection. A brain MRI showed that the bilateral frontal and left parietal lobes were injured. After intensive care in the acute phase, he had a TRH treatment (2 weeks or 4 weeks at each treatment with intravenous drip or intramuscular infusion) in the subacute to beginning of recovery phase, and again thereafter at 6 months, 1 and a half years, 2 years and 4 months, and 3 years and 4 months after the onset of AESD. Upon each treatment, the recovery of cognitive, verbal, and motor dysfunction appeared soon after the start, although the first 4 treatments were more effective than the final treatment. Once recovered, motor function was easily maintained and moreover improved little by little, however verbal expression ability tended to deteriorate several months after TRH treatment.
In conclusion, TRH treatment after encephalopathy with massive injury including frontal and parietal parts of the brain was mostly effective on motor dysfunctions, and especially for the first couple of years.
In conclusion, TRH treatment after encephalopathy with massive injury including frontal and parietal parts of the brain was mostly effective on motor dysfunctions, and especially for the first couple of years.