17. Biofunctional Chemistry, Biotechnology » Oral B

Academic Program [Oral B]

[E1661-1am] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 9:00 AM - 11:10 AM E1661 (1611, Bldg. 16 [1F])

Chair: Hiromu Kashida, Tamaki Endoh

+Add all to schedule

9:00 AM - 9:20 AM

[E1661-1am-01] Development of Cu(II)-responsive DNAzymes by chemoenzymatic incorporation of picolinic acid ligands

^○Kohei Sakurai¹, Yusuke Takezawa¹, Mitsuhiko Shionoya¹ (1. Grad. School of Science, The Univ. of Tokyo)

[Lang.] English

9:20 AM - 9:40 AM

[E1661-1am-02] Metal-dependent Regulation of Hybridization Behaviors of DNA Strands Containing Iminodiacetic Acid-modified Uracil Bases

^○Keita Mori¹, Yusuke Takezawa¹, Mitsuhiko Shionoya¹ (1. Grad. School of Science, The Univ. of Tokyo)

[Lang.] English

9:40 AM - 10:00 AM

[E1661-1am-03] Development of a sequencing method for XNA by using duplex formation

^○Hiromu Kashida¹, Emiri Kagawa¹, Yuka Shimizu¹, Keisuke Toya¹, Yuichiro Aiba², Osami Shoji², Hiroyuki Asanuma¹ (1. Grad. Sch. Eng., Nagoya Univ., 2. Grad. Sch. Sci., Nagoya Univ.)

[Lang.] Japanese

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:30 AM

[E1661-1am-04] Development of PureCap Analogs for Co-transcriptional Capping Enable Synthesis of Fully Capped Messenger RNA

^○Masahito Inagaki¹, Naoko Abe¹, Zhenmin Li¹, Yuko Nakashima^1,2, Susit Acharyya¹, Kazuya Ogawa¹, Daisuke Kawaguchi¹, Haruka Hiraoka¹, Bannno Ayaka¹, Zheyu Meng¹, Mizuki Tada¹, Tatsuma Ishida¹, Pingxue Lyu¹, Kengo Kokubo¹, Hirotaka Murase¹, Fumitaka Hashiya², Yasuaki Kimura¹, Satoshi Uchida^4,3, Abe Hiroshi^1,5,6,2 (1. Nagoya University, 2. Research Center for Materials Science, Nagoya University, 3. Kyoto Prefectural University of Medicine, 4. iCONM, 5. JST-CREST, 6. iGCORE)

[Lang.] Japanese

10:30 AM - 10:50 AM

[E1661-1am-05] NMR analysis of mismatch base pair recognition mechanism by naphthyridine derivatives

^○Shuhei Sakurabayashi^1,2, Kyoko Furuita¹, Noriaki Sugiura², Takeshi Yamada², Toshimichi Fujiwara¹, Kazuhiko Nakatani², Chojiro Kojima^1,3 (1. Institute for Protein Research, Osaka University, 2. SANKEN, Osaka University, 3. Yokohama National University)

[Lang.] Japanese

10:50 AM - 11:10 AM

[E1661-1am-06] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (86): Intracellular multicolor detection of multiple chemicals using signaling light-up aptamers

^○Tamaki Endoh¹, Jia-Heng Tan², Shuo-Bin Chen², Naoki Sugimoto^1,3 (1. FIBER, Konan University, 2. Sun Yat-sen Universsity, 3. FIRST, Konan University)

[Lang.] English

Academic Program [Oral B]

[E1661-1vn] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 4:10 PM - 6:40 PM E1661 (1611, Bldg. 16 [1F])

Chair: Koji Oohora, Nobutaka Fujieda

+Add all to schedule

4:10 PM - 4:30 PM

[E1661-1vn-01] Proposed BciC enzymatic hydrolysis and decarboxylation mechanism

^○Mitsuaki Hirose¹, Jiro Harada², Yuichiro Kashiyama³, Hitoshi Tamiaki¹ (1. Ritsumeikan Univ., 2. Kurume Univ., 3. Fukui Univ. of Technol.)

[Lang.] English

4:30 PM - 4:50 PM

[E1661-1vn-02] Fabrication of Oil-in-Water (O/W) emulsions using enzyme reactive self-assembling peptides

^○Ayato Higuchi¹, Rie Wakabayashi¹, Masahiro Goto^1,2, Noriho Kamiya^1,2 (1. The Univ. of Kyushu, 2. Center for Future Chemistry, The Univ. of Kyushu)

[Lang.] Japanese

4:50 PM - 5:10 PM

[E1661-1vn-03] Dispersion of protein nanoparticle in water/DMSO mixed solvent

^○Maika Yamashita¹, Norifumi Kawakami¹, Kenji Miyamoto¹ (1. Keio University)

[Lang.] English

5:10 PM - 5:30 PM

[E1661-1vn-04] Studies on the association character and structural analysis of antibody light chain that tetramerizes by domain swapping

^○Takahiro Sakai¹, Shohei Yamaguchi¹, Tsuyoshi Mashima¹, Naoya Kobayashi¹, Hideaki Ogata⁴, Emi Hifumi², Taizo Uda³, Shun Hirota¹ (1. Nara Inst. Sci. Tech., 2. Oita Univ., 3. ISIT, 4. University of Hyogo)

[Lang.] English

Break （5:30 PM - 5:40 PM）

5:40 PM - 6:00 PM

[E1661-1vn-05] Development of Artificial Metalloenzymes with 2-His-1-Carboxylate Facial Triad toward Stereoselective Michael Addition Reaction

^○Ryusei Matsumoto¹, Saho Yoshioka², Yoshitsugu Morita¹, Nobutaka Fujieda^1,2 (1. Osaka Metropolitan University, 2. Osaka Prefecture University)

[Lang.] Japanese

6:00 PM - 6:20 PM

[E1661-1vn-06] Catalytic C–H bond amination by engineered hemoproteins containing iron porphycene as an artificial cofactor

^○Yoshiyuki Yoshiyuki¹, Koji Oohora¹, Takashi Hayashi¹ (1. Osaka University)

[Lang.] English

6:20 PM - 6:40 PM

[E1661-1vn-07] Directed Evolution of Myoglobin Reconstituted with an Iron Corrole Complex: Development of Artificial Peroxidase with Enhanced Catalytic Activity

^○Koki Takeuchi¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Graduate School of Engineering, Osaka University)

[Lang.] Japanese

Academic Program [Oral B]

[E1662-1vn] 17. Biofunctional Chemistry, Biotechnology

Wed. Mar 22, 2023 4:10 PM - 6:40 PM E1662 (1612, Bldg. 16 [1F])

Chair: Masayasu Taki, Yoshitaka Koseki

+Add all to schedule

4:10 PM - 4:30 PM

[E1662-1vn-01] Design and application of functional oligonucleotides encoding the information of intracellular target metabolite

^○Yuto Motohashi¹, Shuhei Moritani¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Aoyama Gakuin University)

[Lang.] English

4:30 PM - 4:50 PM

[E1662-1vn-02] Functional Thin-Layer Chromatography for Tissue Glutathione Imaging

^○Tatsuya Nishihara¹, Koki Nishida¹, Rika Tsukame¹, Kazuhito Tanabe (1. Aoyama Gakuin University)

[Lang.] Japanese

4:50 PM - 5:10 PM

[E1662-1vn-03] Development of prodrug nanoparticles with highly selective drug release in cancer cells

^○Aki Shibata¹, Yoshitaka Koseki¹, Keita Tanita¹, Ryuju Suzuki¹, Anh T.N. Dao^1,2, Hitoshi Kasai¹ (1. IMRAM, Tohoku University, 2. Nagasaki University)

[Lang.] English

5:10 PM - 5:30 PM

[E1662-1vn-04] Synthesis of β-lactamase-mediated activation of an SN-38-cephalosporin conjugate and their anticancer properties

^○Yoshitaka Koseki¹, Mitsuki Uehara¹, Ryuuju Suzuki¹, Anh Thi Ngoc Dao², Hitoshi Kasai¹ (1. Tohoku Univ., 2. Nagasaki Univ.)

[Lang.] Japanese

Break （5:30 PM - 5:40 PM）

5:40 PM - 6:00 PM

[E1662-1vn-05] Viscosity-Responsiveness and Melanosomal Visualization in Living Cells using Water-Soluble Fluorescent Probe

^○Junya Adachi¹, Haruka Oda¹, Toshiaki Fukushima¹, Hiroka Sugai², Kohei Sato¹, Hiroshi Kimura¹, Kazushi Kinbara¹ (1. Tokyo Inst. Tech., 2. Univ. of Tsukuba)

[Lang.] English

6:00 PM - 6:20 PM

[E1662-1vn-06] Structure-property relationships of NIR-emissive phospha-rhodamine dyes and their utilization in cell imaging

^○Yoshiki Tanaka¹, Masayasu Taki², Shigehiro Yamaguchi^1,2 (1. Graduate school of science, Nagoya University, 2. ITbM, Nagoya University)

[Lang.] English

6:20 PM - 6:40 PM

[E1662-1vn-07] Design, synthesis, and chiroptical properties of figure-eight shaped macrocycles composed of bispyrrolidinoindoline alkaloidal scaffold

^○Tasuku Honda¹, Daiji Ogata², Makoto Tsurui³, Takahiro Muraoka⁴, Yuichi Kitagawa³, Yasuchika Hasegawa³, Junpei Yuasa², Hiroki Oguri¹ (1. The University of Tokyo, 2. Tokyo University of Science, 3. Hokkaido University, 4. Tokyo University of Agriculture and Technology)

[Lang.] English

Academic Program [Oral B]

[E1662-2am] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 9:00 AM - 11:30 AM E1662 (1612, Bldg. 16 [1F])

Chair: Noriyuki Uchida, Shinya Hanashima

+Add all to schedule

9:00 AM - 9:20 AM

[E1662-2am-01] Investigation of the relationship between hydration behavior and structural characteristics of carbohydrates by solution NMR measurements and molecular simulations

^○Hiroaki Tatsuoka¹, Takumi Yamaguchi^1,2,3 (1. School of Materials Science, Japan Advanced Institute of Science and Technology, 2. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3. Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences)

[Lang.] Japanese

9:20 AM - 9:40 AM

[E1662-2am-02] Modification of membrane properties of small extracellular vesicle exosomes using lipid exchange

^○Shinya Hanashima^1,2, Tomokazu Yasuda¹, Kazuya Kabayama¹, Koichiro M Hirosawa³, Kenichi G. N. Suzuki³ (1. Graduate School of Science, Osaka University, 2. Department of Engineering, Tottori University, 3. iGCORE, Gifu University)

[Lang.] Japanese

9:40 AM - 10:00 AM

[E1662-2am-03] Development of Cancer-targeting Agents Based on Near-infrared-absorbing Diradical-platinum Complexes toward Photothermal Therapy

^○Ryota Sawamura¹, Atsuko Masuya-Suzuki², Hao Thi Tran³, Long Binh Vong³, Yukio Nagasaki³, Nobuhiko Iki¹ (1. Grad. Sch. Env. Stud., Tohoku Univ., 2. Grad. Sch. Sci. Tech. Innov., Yamaguchi Univ., 3. Grad. Sch. Pure Appl. Sci., Univ. of Tsukuba)

[Lang.] English

10:00 AM - 10:20 AM

[E1662-2am-04] Fabrication and Evaluation of Drug-Wrapped Adhesive Nanomaterials with epidermal regeneration ability

^○Yota Shiba¹, Genta Yagami¹, Tadahiro Fuyama¹, Hideaki Sumiyoshi², Yutaka Inagaki², Yosuke OKamura^1,3 (1. Grad. Sch. of Eng., Tokai Univ., 2. Tokai Univ. Sch. of Med., 3. Micro/Nano Tech. Center, Tokai Univ.)

[Lang.] Japanese

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:50 AM

[E1662-2am-05] Photoresponsive Membrane Deformation for Highly Efficient Encapsulation of Biomacromolecules and Its Application to in vivo Phage Display Method

^○Noriyuki Uchida¹, Yunosuke Ryu¹, Teruhiko Matsubara², Toshinori Sato², Yasutaka Anraku³, Takahiro Muraoka^1,4 (1. Tokyo Univ. Agri. and Tech., 2. Keio University, 3. The Univ. of Tokyo , 4. KISETC)

[Lang.] English

10:50 AM - 11:10 AM

[E1662-2am-06] Development of an amphiphilic peptide that self-assembles into helical fibers and controlling of bioadhesion properties by light

^○Atsuya Yaguchi¹, Noriyuki Uchida¹, Itsuki Ajioka^2,3, Takahiro Muraoka^1,3 (1. Tokyo Univ. of Agri. and Tech., 2. Tokyo Med. and Dent. Univ., 3. KISTEC)

[Lang.] Japanese

11:10 AM - 11:30 AM

[E1662-2am-07] Phase transfer of co-assembled peptide supramolecules

^○Rie Wakabayashi¹, Hiroki Obayashi¹, Noriho Kamiya, Masahiro Goto (1. Faculty of Engineering, Kyushu University)

[Lang.] Japanese

Academic Program [Oral B]

[E1661-2am] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 9:00 AM - 11:30 AM E1661 (1611, Bldg. 16 [1F])

Chair: Tomohiro Doura, Tomonori Tamura

+Add all to schedule

9:00 AM - 9:20 AM

[E1661-2am-01] Development of fast blinking fluorophores for real-time single-molecule super-resolution imaging

^○Bochao Li¹, Toshiyuki Kowada¹, Takahiro Fujiwara², Shin Mizukami¹ (1. Tohoku Univ., 2. Kyoto Univ.)

[Lang.] English

9:20 AM - 9:40 AM

[E1661-2am-02] Optical regulation of intracellular protein localization using photochromic protein dimerizers

^○Toshizo Sato¹, Toshiyuki Kowada^1,2, Satoshi Hamaguchi¹, Toshitaka Matsui^1,2, Shin Mizukami^1,2 (1. Graduate School of Life Sciences, Tohoku University, 2. Institute of Multidisciplinary Research for Advanced Materials, Tohoku University)

[Lang.] Japanese

9:40 AM - 10:00 AM

[E1661-2am-03] pH-Responsive and Peptide Sequence-Specific Dynamic Covalent Bond Chemistry

^○Yuto Ohno¹, Alexander Vinogradov¹, Hiroaki Suga¹ (1. The University of Tokyo)

[Lang.] English

10:00 AM - 10:20 AM

[E1661-2am-04] Discovery of CFA-type Covalent Inhibitors that Modulate Activity of Beta Oxidation Pathway Based on FBDD Approach

^○ruikang Yin¹, Kazuya Inoue¹, Shohei Uchinomiya¹, Akio Ojida¹ (1. kyushu Universitity)

[Lang.] Japanese

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:50 AM

[E1661-2am-05] Development of second generation NASA warhead for covalent inhibitors

^○Masaharu Kawano¹, Shunsuke Murakawa¹, Tomonori Tamura¹, Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto University, 2. ERATO JST)

[Lang.] English

10:50 AM - 11:10 AM

[E1661-2am-06] New developments in FixEL method incorporating chemical sensors

^○Takeharu Mino¹, Hiroshi Nonaka^1,2, Seiji Sakamoto², Mamoru Ishikawa², Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto University, 2. JST ERATO)

[Lang.] Japanese

11:10 AM - 11:30 AM

[E1661-2am-07] Chemogenetic regulation of adenosine A_2A receptor focusing on subtype selectivity of the antagonists

^○Yuma Matsuoka¹, Tomohiro Doura¹, Shigeki Kiyonaka¹ (1. Nagoya University)

[Lang.] Japanese

Academic Program [Oral B]

[E1662-2pm] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 1:10 PM - 3:40 PM E1662 (1612, Bldg. 16 [1F])

Chair: Satoshi Abe, Takahiro Muraoka

+Add all to schedule

1:10 PM - 1:30 PM

[E1662-2pm-01] Modulation of the activity of enzyme assembled on DNA scaffold

^○Peng Lin¹, Tomohiko Hayashi², Huyen Dinh³, Eiji Nakata¹, Masahiro Kinoshita ^1,4, Takashi Morii¹ (1. Kyoto University, 2. Niigata University, 3. Humboldt University of Berlin, 4. Chiba University)

[Lang.] English

1:30 PM - 1:50 PM

[E1662-2pm-02] Effect of charge around thiol group on promoting disulfide bonds-containing protein native structure formation

^○Mai Kitamura¹, Takahiro Muraoka^1,2 (1. Tokyo University of Agriculture and Technology, 2. KISTEC)

[Lang.] Japanese

1:50 PM - 2:10 PM

[E1662-2pm-03] Development of high-active protein folding promotors like enzyme

^○Shunsuke Okada¹, Masaki Okumura², Takahiro Muraoka^1,3 (1. Tokyo Univ. of Agr. and Tech., 2. Tohoku Univ., 3. KISTEC)

[Lang.] English

2:10 PM - 2:30 PM

[E1662-2pm-04] In-cell protein crystal engineering for structure determination of intrinsically disordered protein

^○Mariko Kojima¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

Break （2:30 PM - 2:40 PM）

2:40 PM - 3:00 PM

[E1662-2pm-05] Crystallization of ferritin directly from E. Coli cell lysate and structure determination.

^○BASUDEV MAITY¹, Koki Date¹, Satoshi Abe¹, Takafumi Ueno¹ (1. TOKYO INSTITUTE OF TECHNOLOGY)

[Lang.] English

3:00 PM - 3:20 PM

[E1662-2pm-06] Engineering of in-cell protein crystals for the construction of solid materials

^○Satoshi Abe¹, Junko Tanaka¹, Yuto Nakasuji¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

3:20 PM - 3:40 PM

[E1662-2pm-07] In-Cell Engineering of Protein Crystals into Hybrid Solid Catalysts for Artificial Photosynthesis

^○Tiezheng Pan¹, Basudev Maity¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

Academic Program [Oral B]

[E1661-2pm] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 1:10 PM - 3:40 PM E1661 (1611, Bldg. 16 [1F])

Chair: Shuntaro Takahashi, Fumitaka Hashiya

+Add all to schedule

1:10 PM - 1:30 PM

[E1661-2pm-01] Genome scale DNA assembly using modified primers

^○Fumitaka Hashiya^1,6, Kaoru Onda², Kohei Nomura², Gao Yiuno², Hirotaka Murase², Kosuke Nakamoto², Masahito Inagaki², Haruka Hiraoka², Naoko Abe², Yasuaki Kimura², Natsuhisa Oka^3,4,6, Goro Terai^5,6, Kiyoshi Asai^5,6, Hiroshi Abe^1,2,6,7 (1. Nagoya University, Research Center for Materials Science, 2. Graduate School of Science, Nagoya University, 3. Department of Chemistry and Biomolecular Science, Gifu University, 4. Institute for Glyco-core Research (iGCORE), Gifu University, 5. Department of Computational Biology and Medical Sciences, University of Tokyo, 6. CREST, Japan Science and Technology Agency, 7. Institute for Glyco-core Research (iGCORE), Nagoya University)

[Lang.] English

1:30 PM - 1:50 PM

[E1661-2pm-02] Development of a DNA assembly technology using modified nucleic acids

^○Mikiya Kase¹, Masahito Inagaki¹, Haruka Hiraoka¹, Humitaka Hashiya¹, Naoko Abe¹, Yasuaki Kimura¹, Hiroshi Abe¹ (1. The Univ. of Nagoya)

[Lang.] English

1:50 PM - 2:10 PM

[E1661-2pm-03] Light-triggered control of rolling circle transcription aiming for RNA interference inside cells

^○Yusuke Yonamine¹, Wei Jie Cheah², Hideyuki Mitomo¹, Kuniharu Ijiro¹ (1. RIES, Hokkaido Univ., 2. Grad. Sch. Life Sci., Hokkaido Univ.)

[Lang.] Japanese

2:10 PM - 2:30 PM

[E1661-2pm-04] Improvement of chemical pseudo-primer extension reaction of L-aTNA based on reaction mechanism analysis

^○Hikari Okita¹, Keiji Murayama¹, Hiroyuki Asanuma¹ (1. Nagoya Univ.)

[Lang.] Japanese

Break （2:30 PM - 2:40 PM）

2:40 PM - 3:00 PM

[E1661-2pm-05] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (87) : Prediction of ligand binding by hydration analysis of guanine quadruplex using high pressure

^○Shuntaro Takahashi¹, Saki Matsumoto¹, Tatsuya Ohyama¹, Sudipta Bhowmik^2,3, Naoki Sugimoto^1,4 (1. Konan Univ. FIBER, 2. Calcutta Univ., 3. SBV Univ. MGMARI, 4. Konan Univ. FIRST)

[Lang.] English

3:00 PM - 3:20 PM

[E1661-2pm-06] Development of methods for the efficient ligation of staple nicks in DNA origami

^○Arivazhagan Rajendran¹, Kirankumar Krishnamurthy¹, Eiji Nakata¹, Takashi Morii¹ (1. Kyoto University)

[Lang.] English

3:20 PM - 3:40 PM

[E1661-2pm-07] Photocatalytic profiling of G4 DNA-interacting proteins

^○Ahmed Mostafa Abdelhady^1,2, Kazumitsu Onizuka^1,2, Tatsuki Masuzawa³, Shinichi Sato⁴, Keita Nakane⁴, Takanori Oyoshi³, Fumi Nagatsugi^1,2 (1. Graduate School of Science, Tohoku University, 2. IMRAM, Tohoku University, 3. Graduate School of Science and Technology, Shizuoka University, 4. FRIS, Tohoku University)

[Lang.] English

Academic Program [Oral B]

[E1661-2vn] 17. Biofunctional Chemistry, Biotechnology

Thu. Mar 23, 2023 4:10 PM - 6:40 PM E1661 (1611, Bldg. 16 [1F])

Chair: Takafumi Furuhata, Tomoshige Fujino

+Add all to schedule

4:10 PM - 4:30 PM

[E1661-2vn-01] Intracellular artificial construction of droplets based on an amphiphilic YK peptide tag and client protein enrichment

^○Masahiro Hashimoto¹, Takayuki Miki¹, Hiroki Takahashi¹, Sae Nakayama¹, Hisakazu Mihara¹ (1. Tokyo Institute of Technology, School of Life Science and Technology)

[Lang.] English

4:30 PM - 4:50 PM

[E1661-2vn-02] Pattern enrichment analysis for efficient peptide ligands selection from a phage library

^○Takayuki Miki¹, Keigo Namii¹, Kenta Seko¹, Shota Kakehi¹, Hisakazu Mihara¹ (1. School of Life Science and Technology, Tokyo Instituite of Technology)

[Lang.] Japanese

4:50 PM - 5:10 PM

[E1661-2vn-03] Improvement of the diversity of monobody and macrocyclic peptide libraries in mRNA display technology

^○Shun Umemoto¹, Taishi Kondo¹, Tomoshige Fujino¹, Gosuke Hayashi¹, Hiroshi Murakami^1,2 (1. Nagoya University, 2. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University)

[Lang.] Japanese

5:10 PM - 5:30 PM

[E1661-2vn-04] Anti-azobenzene artificial antibodies for photocontrollable binding

^○Tomoshige Fujino¹, Mamoru Funane¹, Naoya Murata¹, Tatsuyuki Yoshii², Gosuke Hayashi¹, Shinya Tsukiji², Hiroshi Murakami^1,3 (1. Graduate School of Engineering, Nagoya University, 2. Graduate School of Engineering, Nagoya Institute of Technology, 3. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University)

[Lang.] Japanese

Break （5:30 PM - 5:40 PM）

5:40 PM - 6:00 PM

[E1661-2vn-05] A machine learning guided thiopeptide library design for the discovery of de novo thiopeptide binders

^○Jun Shi Chang¹, Alexander Vinogradov¹, Yuki Goto¹, Hiroaki Suga¹ (1. Tokyo Univeristy)

[Lang.] English

6:00 PM - 6:20 PM

[E1661-2vn-06] Enzyme mediated one-pot synthesis of branched polyubiquitin (K48/K63) chain via photo-induced stepwise synthesis

^○Phebee Angeline Devadasan Racheal¹, Takafumi Furuhata¹, Iori Murayama¹, Usano Toyoda¹, Akimitsu Okamato¹ (1. The Univ. of Tokyo)

[Lang.] English

6:20 PM - 6:40 PM

[E1661-2vn-07] Regulation of enzyme activity by perturbation to conformational change process using antibody mimetic "monobody"

^○Ibuki Nakamura¹, Hiroshi Amesaka², Mizuho Hara², Kento Yonezawa¹, Hironari Kamikubo¹, Shun-ichi Tanaka², Shun Hirota¹, Takashi Matsuo¹ (1. Division of Materials Science, Nara Inst. Sci. Tech., 2. Department of Biomolecular Chemistry, Kyoto Prefectural University)

[Lang.] Japanese

Academic Program [Oral B]

[E1661-3am] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 9:00 AM - 11:30 AM E1661 (1611, Bldg. 16 [1F])

Chair: Shinya Ariyasu, Shun Hirota

+Add all to schedule

9:00 AM - 9:20 AM

[E1661-3am-01] Accumulation of Protein Cage into in-cell Protein Crystal

^○THUC TOAN PHAM¹, Koki Date¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology/ School of Life Science and Technology)

[Lang.] English

PDF Download

Schedule

9:20 AM - 9:40 AM

[E1661-3am-02] Construction of Antifreeze protein like semi-clathrate hydrate in the ferritin cage

^○Jiaxin Tian¹, Maity Basudev¹, Satoshi Abe¹, Takafumi Ueno¹ (1. Tokyo Institute of Technology)

[Lang.] English

PDF Download

Schedule

9:40 AM - 10:00 AM

[E1661-3am-03] Structure analysis of pH-responsive piston dynamics of R-body

^○Koki DATE¹, Thuc Toan PHAM¹, Hyeonho LEE¹, Takayuki UCHIHASHI², Hironari KAMIKUBO³, Chihong SONG⁴, Kazuyoshi MURATA⁴, Takafumi UENO¹ (1. School of Life Science and Technology, Tokyo Institute of Technology, 2. Graduate School of Science, Nagoya University, 3. School of Science and Technology, NAIST, MS, 4. ExCELLS/NIPS)

[Lang.] Japanese

PDF Download

Schedule

10:00 AM - 10:20 AM

[E1661-3am-04] Developing protein-cellulose nanocrystal hybrid films for structural coloration

^○Kosuke Kikuchi¹, Bruno Frka-Petesic², Silvia Vignolini², Takafumi Ueno¹ (1. Tokyo Institute of Technology, 2. University of Cambridge)

[Lang.] English

PDF Download

Schedule

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:50 AM

[E1661-3am-05] Construction of a stimuli-responsive cytochrome c-based hydrogel driven by its folding and unfolding behavior

^○Kazuki Kageyama¹, Takahiro Urayama¹, Koji Oohora¹, Takashi Hayashi¹ (1. Osaka university)

[Lang.] English

PDF Download

Schedule

10:50 AM - 11:10 AM

[E1661-3am-06] Development of Myoglobin-based Artificial Metalloenzymes: Nitrile Synthesis via Dehydration of Aldoximes

^○Miteki Abe¹, Shunsuke Kato¹, Takashi Hayashi¹ (1. Osaka University)

[Lang.] Japanese

PDF Download

Schedule

11:10 AM - 11:30 AM

[E1661-3am-07] ATP Responsive Two-Dimensional Biomaterial from Biomolecular machine GroEL

^○TONMOY RAY^1,2, TAKUZO AIDA^1,2 (1. The University of Tokyo, 2. RIKEN CEMS)

[Lang.] English

PDF Download

Schedule

Academic Program [Oral B]

Export as PDF

[E1662-3am] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 9:00 AM - 11:30 AM E1662 (1612, Bldg. 16 [1F])

Chair: Hiroshi Nonaka, Yusuke Nasu

+Add all to schedule

9:00 AM - 9:20 AM

[E1662-3am-01] Screening of catalytic antibodies against PD-1 and PD-L1 and the features of clones obtained

Emi Hifumi², Tamami Nonaka², Hiroaki Taguchi³, ^○Taizo Uda^1,2 (1. ISIT, 2. OIta Univ., 3. Suzuka Univ. Med. Sci.)

[Lang.] Japanese

PDF Download

Schedule

9:20 AM - 9:40 AM

[E1662-3am-02] Generation of stable microtubule superstructures induced by Tau-derived peptide-fused tetrameric proteins

^○Hiroshi Inaba¹, Yurina Sueki¹, Muneyoshi Ichikawa², Arif Md. Rashedul Kabir³, Takashi Iwasaki⁴, Akira Kakugo³, Kazuki Sada³, Kazunori Matsuura¹ (1. Graduate School of Engineering, Tottori University, 2. Graduate School of Science and Technology, Nara Institute of Science and Technology, 3. Graduate School of Science, Hokkaido University, 4. Graduate School of Agricultural Sciences, Tottori University)

[Lang.] Japanese

PDF Download

Schedule

9:40 AM - 10:00 AM

[E1662-3am-03] Artificial control of protein secretion using thermogenetic dissociation module

^○Mizuki Endo¹, Takeaki Ozawa¹ (1. The University of Tokyo)

[Lang.] Japanese

PDF Download

Schedule

10:00 AM - 10:20 AM

[E1662-3am-04] Genetically encoded fluorescent biosensors for L-lactate

^○Yusuke Nasu¹, Yuki Kamijo¹, Giang Le¹, Saaya Hario¹, Robert E Campbell¹ (1. The University of Tokyo)

[Lang.] Japanese

PDF Download

Schedule

Break （10:20 AM - 10:30 AM）

10:30 AM - 10:50 AM

[E1662-3am-05] Development of new labeling reagents for endogenous receptors in the live mouse brain and their application to multiplex imaging

^○Hiroshi Nonaka^1,2, Mengchu Wang³, Takuma Takeshi¹, Kazuki Shiraiwa¹, Seiji Sakamoto^1,2, Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto Univ., 2. JST, ERATO, 3. Faculty of Engineering, Kyoto Univ.)

[Lang.] Japanese

PDF Download

Schedule

10:50 AM - 11:10 AM

[E1662-3am-06] Photooxidation-driven proximity labeling for mapping neurotransmitter receptor interactome in live mouse brain

^○Tomonori Tamura¹, Mikiko Takato¹, Seiji Sakamoto^1,2, Hiroshi Nonaka^1,2, Itaru Hamachi^1,2 (1. Kyoto University, 2. JST ERATO)

[Lang.] Japanese

PDF Download

Schedule

11:10 AM - 11:30 AM

[E1662-3am-07] Identification of a gene involved in lanthanide switch by analysis of the mutants isolated during the cultivation of Methylosinus trichosporium OB3b with glycerol

^○Wataru Shiina¹, Hidehiro Ito¹, Toshiaki Kamachi¹ (1. Tokyo Institute of Technology)

[Lang.] English

PDF Download

Schedule

Academic Program [Oral B]

Export as PDF

[E1662-3pm] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 1:10 PM - 3:40 PM E1662 (1612, Bldg. 16 [1F])

Chair: Hideaki Yoshimura, Kenji Monde

+Add all to schedule

1:10 PM - 1:30 PM

[E1662-3pm-01] Signal transduction mechanism of membrane receptors on ligand binding and cluster formation: Analysis through single-molecule imaging.

^○Hideaki Yoshimura¹, Takeaki Ozawa¹ (1. The University of Tokyo)

[Lang.] English

PDF Download

Schedule

1:30 PM - 1:50 PM

[E1662-3pm-02] Quantitative analysis of Akt isoform-specific temporal activation dynamics and downstream signaling regulation with mathematical model-aided optogenetics

^○Yuka Sekine¹, Genki Kawamura¹, Takeaki Ozawa¹ (1. The University of Tokyo)

[Lang.] English

PDF Download

Schedule

1:50 PM - 2:10 PM

[E1662-3pm-03] Dissecting the role of Akt2 in cellular metabolism by optogenetics-aided trans-omics analysis

^○Genki Kawamura¹, Takeaki Ozawa¹ (1. The University of Tokyo)

[Lang.] English

PDF Download

Schedule

2:10 PM - 2:30 PM

[E1662-3pm-04] Development of photoreactive sphingomyelin synthase 2 inhibitors and evaluation of its binding domain analysis

^○Mirano Abe¹, Yuta Murai¹, Takeo Sato¹, Miho Sanagi¹, Susumu Mitsutake², Makoto Taniguchi³, Kenji Monde¹ (1. Hokkaido University, 2. Saga University, 3. Kanazawa Medical University)

[Lang.] English

PDF Download

Schedule

Break （2:30 PM - 2:40 PM）

2:40 PM - 3:00 PM

[E1662-3pm-05] Contribution of moleculae weight of ligand functionalized poly-L-glutamates to the inhibition of cancer cell proliferation

^○Masahiko Nakamoto¹, Yuki Koba¹, Michiya Matsusaki¹ (1. Osaka University)

[Lang.] Japanese

PDF Download

Schedule

3:00 PM - 3:20 PM

[E1662-3pm-06] Point-of-care electrochemical biosensors for measuring anti-SARS-CoV-2 neutralising IgG/sIgA antibodies and antioxidant activity in saliva

^○Eiichi Tamiya^1,2, Shuto Osaki¹, Tomoko Tsuchihashi³, Hiromi Ushijima³, Keiichi Tsukinoki⁴ (1. AIST, 2. Osaka Univ., 3. Biodevicetechnology Ltd., 4. Kanagawa Dental Univ.)

[Lang.] Japanese

PDF Download

Schedule

3:20 PM - 3:40 PM

[E1662-3pm-07] Determination of Permeation Kinetics of Coumarin at Lipid Bilayer of Liposomes by Using Capillary Electrophoresis with Moment Analysis Theory

^○Kanji Miyabe¹, Shunta Inaba¹, Momoko Umeda¹ (1. Rikkyo University)

[Lang.] Japanese

PDF Download

Schedule

Academic Program [Oral B]

Export as PDF

[E1661-3pm] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 1:30 PM - 3:40 PM E1661 (1611, Bldg. 16 [1F])

Chair: Hisae Tateishi-Karimata, Yousuke Katsuda

+Add all to schedule

1:30 PM - 1:50 PM

[E1661-3pm-01] Exploring new methods in regulating circular RNA production using cellular model

^○Lu Ni¹, Takeshi Yamada¹, Kazuhiko Nakatani¹ (1. Osaka University)

[Lang.] English

PDF Download

Schedule

1:50 PM - 2:10 PM

[E1661-3pm-02] Synthesis of Hoechst-modified DNA that accumulated in the cell nucleus and its application.

^○Hiroki Makanai¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Aoyama Gakuin University)

[Lang.] English

PDF Download

Schedule

2:10 PM - 2:30 PM

[E1661-3pm-03] A nucleic acid medicine that suppresses target gene expression based on RNA structure hacking

^○Takuto Kamura¹, Yousuke Katsuda¹, Taishi Nakamura^2,3, Kenichi Tsujita³, Yusuke Kitamura¹, Masaki Hagihara⁴, Shin-ichi Sato⁵, Toshihiro Ihara¹ (1. Faculty of Advanced Science and Technology, Kumamoto University, 2. Department of Medical Information Sciences and Administration Planning, Kumamoto University Hospital, 3. Department of Cardiovascular Medicine, Faculty of Life Sciences, Kumamoto University, 4. Faculty of Science and Technology, Hirosaki University, 5. Institute for Chemical Research, Kyoto University)

[Lang.] English

PDF Download

Schedule

Break （2:30 PM - 2:40 PM）

2:40 PM - 3:00 PM

[E1661-3pm-04] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (88): Mechanism of C-quadruplexes formations in response to environmental changes in cancer cells

^○Hisae Tateishi-Karimata¹, Keiko Kawauchi², Naoki Sugimoto^1,2 (1. Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 2. Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University)

[Lang.] English

PDF Download

Schedule

3:00 PM - 3:20 PM

[E1661-3pm-05] Epigenetic methylations suppress droplet formation of DNA G-quadruplex and Arg-rich peptide

^○Mitsuki Tsuruta¹, Keiko Kawauchi¹, Naoki Sugimoto^1,2, Daisuke Miyoshi¹ (1. Konan university, FIRST, 2. Konan university, FIBER)

[Lang.] English

PDF Download

Schedule

3:20 PM - 3:40 PM

[E1661-3pm-06] Effect of structural selective G4 ligand on telomere length and TERRA expression level

^○Yoshiki Hashimoto¹, Takeru Torii¹, Natsuki kinoshita¹, Keiko Kawauchi¹, Hisae Tateishi-Karimata², Naoki Sugimotgo^1,2, Daisuke Miyoshi¹ (1. FIRST, Konan University, 2. FIBER, Konan University)

[Lang.] English

PDF Download

Schedule

Academic Program [Oral B]

Export as PDF

[E1661-3vn] 17. Biofunctional Chemistry, Biotechnology

Fri. Mar 24, 2023 4:10 PM - 6:30 PM E1661 (1611, Bldg. 16 [1F])

Chair: Hidetaka Torigoe, Yuichiro Aiba

+Add all to schedule

4:10 PM - 4:30 PM

[E1661-3vn-01] The first detection of the formation of DNA triplex structure in living human cells and an analysis of base pair dynamics under molecular crowding environment

^○Tomoki Sakamoto^1,2, Yudai Yamaoki^1,2, Takashi Nagata^1,2, Masato Katahira^1,2 (1. Institute of Advanced Energy, 2. Graduate School of Energy Science, Kyoto University)

[Lang.] English

PDF Download

Schedule

4:30 PM - 4:50 PM

[E1661-3vn-02] Investigation of parallel-stranded PNAs for the formation of an invasion complex with double-stranded DNA

^○Masanari Shibata¹, Yuichiro Aiba¹, Masaki Hibino¹, Osami Shoji¹ (1. Nagoya University)

[Lang.] English

PDF Download

Schedule

4:50 PM - 5:10 PM

[E1661-3vn-03] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (81) : Stability prediction of RNA duplexes under various molecular crowding in vitro and in cell

^○Saptarshi Ghosh¹, Shuntaro Takahashi¹, Dipanwita Banerjee¹, Tatsuya Ohyama¹, Tamaki Endoh¹, Hisae Tateishi-Karimata¹, Naoki Sugimoto^1,2 (1. FIBER, Konan University, 2. FIRST, Konan University)

[Lang.] English

PDF Download

Schedule

5:10 PM - 5:30 PM

[E1661-3vn-04] Nucleic Acids Chemistry beyond the Watson-Crick Double Helix (82) : Applications of nearest-neighbor parameters for RNA/DNA hybrid duplexes in the advancement of therapeutics

^○Dipanwita Banerjee¹, Hisae Tateishi-Karimata¹, Saptarshi Ghosh¹, Shuntaro Takahashi¹, Tatsuya Ohyama¹, Tamaki Endoh¹, Maria Toplishek², Marko Trajkovski ², Janez Plavec^2,3,4, Naoki Sugimoto^1,5 (1. FIBER, Konan University, 2. Slovenian NMR Centre, National Institute of Chemistry, 3. EN→FIST Centre of Excellence, 4. Faculty of Chemistry and Chemical Technology, University of Ljubljana, 5. FIRST, Konan University)

[Lang.] English

PDF Download

Schedule

5:30 PM - 5:50 PM

[E1661-3vn-05] Development of single nucleotide polymorphism detection method based on the specific formation of T-Hg-T and C-Ag-C metal-mediated base pair

Kohsei Sekiya¹, Akira Ono², ^○Hidetaka Torigoe¹ (1. Tokyo University of Science, 2. Kanagawa University)

[Lang.] Japanese

PDF Download

Schedule

5:50 PM - 6:10 PM

[E1661-3vn-06] Photosensitized oxidation of NADH analogue by hydrophobic phosphorus(V) porphyrins

^○Hiroko Hasegawa¹, Kazutaka Hirakawa^1,2 (1. Department of Optoelectronics and Nanostructure Science, Graduate School of Science and Technology, Shizuoka University, 2. Applied Chemistry and Biochemical Engineering Course, Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University)

[Lang.] Japanese

PDF Download

Schedule

6:10 PM - 6:30 PM

[E1661-3vn-07] Pore-wall modification of platinum porphyrin co-condensed mesoporous silica nanoparticles and their application to intracellular oxygen concentration imaging

^○Shunsuke Odai¹, Junpei Noguchi¹, Arisa Yamauchi¹, Hidehiro Ito¹, Masaki Okamoto², Toshiaki Kamachi¹ (1. Tokyo institute of technology, 2. Keio University)

[Lang.] Japanese

PDF Download

Schedule

Academic Program [Oral B]

Export as PDF

[E1661-4am] 17. Biofunctional Chemistry, Biotechnology

Sat. Mar 25, 2023 9:00 AM - 11:10 AM E1661 (1611, Bldg. 16 [1F])

Chair: Nobuhiko Hosono, Takashi Matsuo

+Add all to schedule

9:00 AM - 9:20 AM

[E1661-4am-01] Screening of decoy molecules for propane hydroxylation using intracellular Cytochrome P450BM3

^○Yuki Sugai¹, Masayuki Karasawa¹, Yusaku Kadama¹, Kai Yanemura¹, Shinya Ariyasu¹, Yuichiro Aiba¹, Osami Shoji¹ (1. Graduate School of Science, Nagoya University)

[Lang.] Japanese

PDF Download

Schedule

9:20 AM - 9:40 AM

[E1661-4am-02] Dimerization of Artificial Hemoprotein Containing a Tetraphenylporphyrin Derivative Based on Metal Coordination

^○Hiroaki Inaba¹, Yuma Shisaka¹, Garyo Ueda¹, Erika Sakakibara¹, Shinya Ariyasu¹, Yuichiro Aiba¹, Hiroshi Sugimoto², Osami Shoji¹ (1. Graduate school of Science, Nagoya University, 2. RIKEN SPring-8)

[Lang.] English

PDF Download

Schedule

9:40 AM - 10:00 AM

[E1661-4am-03] Whole-Cell Biocatalysts Harboring P450s Triggered by External Additives for Microbial Degradation of Environmental Pollutants

^○Fumiya Ito¹, Shinya Ariyasu¹, Masayuki Karasawa¹, Chie Kasai¹, Yuichiro Aiba¹, Osami Shoji¹ (1. Graduate School of Science, Nagoya University)

[Lang.] Japanese

PDF Download

Schedule

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:30 AM

[E1661-4am-04] Catalytic Hydroxylation of Non-native Substrates by Cytochrome P450BM3 Mutants with Expanded Structural Availability of Decoy Molecules by Directed Evolution

^○Yuya Yokoyama¹, Shinya Ariyasu¹, Masayuki Karasawa¹, Kai Yonemura¹, Yuichiro Aiba¹, Hiroshi Sugimoto², Osami Shoji¹ (1. School of Science, Nagoya University, 2. RIKEN SPring-8)

[Lang.] English

PDF Download

Schedule

10:30 AM - 10:50 AM

[E1661-4am-05] Chemical modification of peptides/proteins using specific affinity of transition metal for alkene

Asuki Okada¹, Tsubasa Kinugawa¹, Shun Hirota¹, ^○Takashi Matsuo¹ (1. Nara Inst. Sci. Tech.)

[Lang.] Japanese

PDF Download

Schedule

10:50 AM - 11:10 AM

[E1661-4am-06] Selective Removal of Denatured Proteins by Metal-Organic Frameworks

^○Hirotaka Taketomi¹, Nobuhiko Hosono¹, Takashi Uemura¹ (1. Grad. Sch. of Eng., The Univ. of Tokyo)

[Lang.] Japanese

PDF Download

Schedule

Sessions

17. Biofunctional Chemistry, Biotechnology » Oral B

[E1661-1am] 17. Biofunctional Chemistry, Biotechnology

[E1661-1vn] 17. Biofunctional Chemistry, Biotechnology

[E1662-1vn] 17. Biofunctional Chemistry, Biotechnology

[E1662-2am] 17. Biofunctional Chemistry, Biotechnology

[E1661-2am] 17. Biofunctional Chemistry, Biotechnology

[E1662-2pm] 17. Biofunctional Chemistry, Biotechnology

[E1661-2pm] 17. Biofunctional Chemistry, Biotechnology

[E1661-2vn] 17. Biofunctional Chemistry, Biotechnology

[E1661-3am] 17. Biofunctional Chemistry, Biotechnology

[E1662-3am] 17. Biofunctional Chemistry, Biotechnology

[E1662-3pm] 17. Biofunctional Chemistry, Biotechnology

[E1661-3pm] 17. Biofunctional Chemistry, Biotechnology

[E1661-3vn] 17. Biofunctional Chemistry, Biotechnology

[E1661-4am] 17. Biofunctional Chemistry, Biotechnology

Authentication