[D1441-4am] 17. Biofunctional Chemistry, Biotechnology

[D1441-4am-07] Construction of Catalytic Target RNA Cleavage Function Installed Chimeric Artificial Nucleic Acids (CANA) toward Development of COVID-19 Treatments-I : Design, Synthesis, and in vitro Properties

^○Kazutoshi Fujita¹, Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yu Mikame⁴, Yasuyuki Araki¹, Tsuyoshi Yamamoto⁴, Asako Yamayoshi⁴, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ., 4. Grad. Sch. Biomed. Sci., Nagasaki Univ.)

[Lang.] Japanese

Keywords:Oligonucleotide therapeutics, RNase H, Catalytic cleavage, RNA cleavage, Chimeric Artificial Nucleic Acids