Academic Program [Oral A]

17. Biofunctional Chemistry, Biotechnology » Oral A

[D1441-4am] 17. Biofunctional Chemistry, Biotechnology

Sat. Mar 25, 2023 9:00 AM - 11:40 AM D1441 (1441, Bldg. 14 [4F])

Chair: Keiji Murayama, Yasuaki Kimura

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9:00 AM - 9:10 AM

[D1441-4am-01] Mitigating the toxicity of gapmer-type antisense oligonucleotide by using acyclic nucleic acid

^○Masaya Higuchi¹, yukiko kamiya¹, hiroyuki asanuma¹ (1. Grad. Sch. Eng., Nagoya Univ.)

[Lang.] Japanese

9:10 AM - 9:20 AM

[D1441-4am-02] The interaction analysis of ¹⁵N-labeled naphthyridine derivatives with repeat DNA by NMR

^○Noriaki Sugiura¹, Takeshi Yamada¹, Shuhei Sakurabayashi¹, Kazuhiko Nakatani¹ (1. SANKEN, Osaka University)

[Lang.] Japanese

9:20 AM - 9:30 AM

[D1441-4am-03] Radiolytic reduction of copper ion and DNA cleavage

^○Kousuke Meisho¹, Tatsuya Nishihara¹, Kazuhito Tanabe¹ (1. Graduate School of Science and Engineering Aoyama Gakuin University)

[Lang.] Japanese

9:30 AM - 9:40 AM

[D1441-4am-04] Fluorescence characterization of Thioflavin T-chelator conjugates

^○Tomoko Wariishi¹, Yuka Kataoka¹, Hiroto Fujita¹, Masayasu Kuwahara¹ (1. Nihon University)

[Lang.] Japanese

9:40 AM - 9:50 AM

[D1441-4am-05] Development of a method for chemical synthesis of long DNAs in a photolithographic flow system

^○Teruyuki Okaniwa¹, Koichiro Miyauchi¹, Aoma Yoshida¹, Yuya Okawara¹, Koki Maruyama¹, Ishin Ono¹, Tatsuhiro Yokoyama¹, Akihiro Ohkubo¹ (1. Tokyo Institute of Technology)

[Lang.] Japanese

9:50 AM - 10:00 AM

[D1441-4am-06] Novel Design Strategy of DNA-Artificial Nucleic Acid Chimera Toward Enhancement of Target RNA Cleavage Activities: Modification Effects of DNA Moiety upon Complex Stabilities and Activity

^○Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yasuyuki Araki¹, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ.)

[Lang.] Japanese

10:00 AM - 10:10 AM

[D1441-4am-07] Construction of Catalytic Target RNA Cleavage Function Installed Chimeric Artificial Nucleic Acids (CANA) toward Development of COVID-19 Treatments-I : Design, Synthesis, and in vitro Properties

^○Kazutoshi Fujita¹, Nozomu Ishiwata¹, Masahito Inagaki², Masaki Nishijima¹, Hironori Hayashi³, Yu Mikame⁴, Yasuyuki Araki¹, Tsuyoshi Yamamoto⁴, Asako Yamayoshi⁴, Eiichi Kodama³, Takehiko Wada¹ (1. IMRAM, Tohoku Univ., 2. Nagoya Univ., 3. IRIDeS, Tohoku Univ., 4. Grad. Sch. Biomed. Sci., Nagasaki Univ.)

[Lang.] Japanese

Break (10:10 AM - 10:20 AM)

10:20 AM - 10:30 AM

[D1441-4am-08] Construction of DNA libraries with random sequences using chemically modified primers and ligation reactions.

^○Naho Takahashi¹, Kohei Nomura², Kaoru Onda², Daisuke Suzuki², Yuuki Murase², Masahito Inagaki², Haruka Hiraoka², Naoko Abe², Fumitaka Hashiya², Yasuaki Kimura², Hiroshi Abe^2,3 (1. Department of science, Nagoya University, 2. Graduate School of Science, Nagoya University,, 3. iGCORE)

[Lang.] Japanese

10:30 AM - 10:40 AM

[D1441-4am-09] Activation of siRNA Triggered by Copper Ion Accumulated in Cancer Cells

^○Yasuhiro Tomida¹, Kunihiko Morohiro¹, Akimitsu Okamoto¹ (1. The Univ. of Tokyo)

[Lang.] Japanese

10:40 AM - 10:50 AM

[D1441-4am-10] Efficiency of stepwise reaction by enzymes assembled on a shape-transformable 3D DNA nanostructure

^○Mei Nakabayashi¹, Peng Lin¹, Nakata Eiji¹, Morii Takashi¹ (1. Kyoto University)

[Lang.] Japanese

10:50 AM - 11:00 AM

[D1441-4am-11] Detailed Analysis of DNA-Scaffolded Bioluminescence Energy Transfer System

^○Koichi Tanimoto¹, Tomoya Niki¹, Yuki Minamide¹, Shiori Tabana¹, Fumiaki Takano¹, Akinori Kuzuya¹ (1. Kansai Univ.)

[Lang.] Japanese

11:00 AM - 11:10 AM

[D1441-4am-12] Efficient Intramolecular Energy Transmission along DNA from Luciferase as intramolecular Excitation Energy sources.

^○Yuki Minamide¹, Koichi Tanimoto¹, Tomoya Niki¹, Shiori Tabana¹, Fumiaki Takano¹, Akinori Kuzuya¹ (1. Kansai Univ.)

[Lang.] Japanese

11:10 AM - 11:20 AM

[D1441-4am-13] DNA Origami as a Scaffold to Assemble Membrane Proteins on an Artificial Compartment

^○Shiwei Zhang¹, Eiji Nakata¹, Takashi Morii¹ (1. Kyoto university)

[Lang.] English

11:20 AM - 11:30 AM

[D1441-4am-14] Development of multidrug-integrated short-chain-nucleic acid drugs for effective chemotherapy of refractory cancer

^○Ryosei Komiyama¹, Kunihiko Morihiro¹, Akimitsu Okamoto¹ (1. The Univ. of Tokyo)

[Lang.] Japanese

11:30 AM - 11:40 AM

[D1441-4am-15] Left-handed quadruplex formation by the binding of mercury ion to thrombin binding aptamer

^○Yui Miyakara¹, Kohsei Sekiya¹, Jiro Kondo², Hidetaka Torigoe¹ (1. Tokyo University of Science, 2. Sophia University)

[Lang.] Japanese

Session information

[D1441-4am] 17. Biofunctional Chemistry, Biotechnology

[D1441-4am-01] Mitigating the toxicity of gapmer-type antisense oligonucleotide by using acyclic nucleic acid

[D1441-4am-02] The interaction analysis of ¹⁵N-labeled naphthyridine derivatives with repeat DNA by NMR

[D1441-4am-03] Radiolytic reduction of copper ion and DNA cleavage

[D1441-4am-04] Fluorescence characterization of Thioflavin T-chelator conjugates

[D1441-4am-05] Development of a method for chemical synthesis of long DNAs in a photolithographic flow system

[D1441-4am-06] Novel Design Strategy of DNA-Artificial Nucleic Acid Chimera Toward Enhancement of Target RNA Cleavage Activities: Modification Effects of DNA Moiety upon Complex Stabilities and Activity

[D1441-4am-07] Construction of Catalytic Target RNA Cleavage Function Installed Chimeric Artificial Nucleic Acids (CANA) toward Development of COVID-19 Treatments-I : Design, Synthesis, and in vitro Properties

[D1441-4am-08] Construction of DNA libraries with random sequences using chemically modified primers and ligation reactions.

[D1441-4am-09] Activation of siRNA Triggered by Copper Ion Accumulated in Cancer Cells

[D1441-4am-10] Efficiency of stepwise reaction by enzymes assembled on a shape-transformable 3D DNA nanostructure

[D1441-4am-11] Detailed Analysis of DNA-Scaffolded Bioluminescence Energy Transfer System

[D1441-4am-12] Efficient Intramolecular Energy Transmission along DNA from Luciferase as intramolecular Excitation Energy sources.

[D1441-4am-13] DNA Origami as a Scaffold to Assemble Membrane Proteins on an Artificial Compartment

[D1441-4am-14] Development of multidrug-integrated short-chain-nucleic acid drugs for effective chemotherapy of refractory cancer

[D1441-4am-15] Left-handed quadruplex formation by the binding of mercury ion to thrombin binding aptamer

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