[D1443-2am] 16. Natural Products Chemistry, Chemical Biology

[D1443-2am-03] Development of novel psoralen-introduced triplex-forming oligonucleotides for the expansion of their target genome sequences

^○Yu Mikame¹, Honoka Eshima¹, Juki Nakao¹, Tsuyoshi Yamamoto¹, Yoshiyuki Hari², Chikara Dohno³, Takehiko Wada⁴, Asako Yamayoshi¹ (1. Grad. Sch. Biomed. Sci., Nagasaki Univ, 2. Fac. of Pharm. Sci., Tokushima Bunri University, 3. SANKEN., Osaka Univ, 4. IMRAM., Tohoku Univ)

[Lang.] Japanese

Keywords:triplex-forming oligonucleotide, Psoralen, Hoogsteen-type hydrogen bond, thermodynamic stability