Academic Program [Oral B]

[E1662-1am] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 9:00 AM - 11:30 AM E1662 (1612, Bldg. 16 [1F])

Chair: Takuya Kaji, Toyonobu Usuki

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9:00 AM - 9:20 AM

[E1662-1am-01] Total synthesis of pigments with azulene skeleton in an edible blue mushroom

^○Kiyotaka Maruoka¹, Ryuju Suzuki¹, Takaaki Kamishima², Yoshitaka Koseki¹, Toshihiro Murafuji³, Hitoshi Kasai¹ (1. IMRM, the Univ. of Tohoku, 2. Genesis Research Institute, Inc., 3. Graduate School of Science and Technology for Innovation, the Univ. of Yamaguchi)

[Lang.] English

9:20 AM - 9:40 AM

[E1662-1am-02] Δ⁴-dinor-OPDAs, novel ancestral jasmonates of Marchantia polymorpha

^○Takuya Kaji¹, Hidenori Yoshimatsu¹, Nobuki Kato¹, Haruka Sakurai¹, Yang Gangqiang², Guillermo H. Jimenez-Aleman³, Roberto Solano³, Minoru Ueda^1,4 (1. Sciences, Tohoku Univ., 2. Pharmacy, Yantai University, 3. CNB-CSIC, 4. Life Sciences, Tohoku Univ.)

[Lang.] Japanese

9:40 AM - 10:00 AM

[E1662-1am-03] JA-Ile-lactone enhanced accumulation of alkaloid in tomato

^○Rina Saito¹, Takuya Kaji², Taichi Okumura², Toshiya Muto¹, Hiroshi Abe³, Sohei Yamagami¹, Yousuke Takaoka², Minoru Ueda^1,2 (1. Grad. Sch. Lifesci., Tohoku Univ., 2. Grad. Sch. Sci., Tohoku Univ., 3. RIKEN BRC)

[Lang.] English

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:30 AM

[E1662-1am-04] Chemical regulation of crosstalk between jasmonate and ethylene by peptide-based chemical tools

^○Yousuke Takaoka¹, Ruiqi Liu¹, Qi Li¹, Minoru Ueda^1,2 (1. Grad. Sci., Tohoku Univ, 2. Grad. Life Sciences, Tohoku Univ)

[Lang.] Japanese

10:30 AM - 10:50 AM

[E1662-1am-05] Glycolipids as ligands and molecular probes for C-type lectin receptor Mincle; synthesis and biological functional analysis

^○Takanori Matsumaru¹, Kana Okubo¹, Kasumi Sakuratani¹, Kodai Sueyoshi¹, Shusuke Fujii¹, Juri Takayama¹, Yamasaki Sho^2,3, Yukari Fujimoto¹ (1. Fac. Sci. Tech., Keio Univ., 2. Research Institute for Microbial Diseases, Osaka Univ., 3. Immunology Frontier Research Center (IFReC), Osaka Univ.)

[Lang.] Japanese

10:50 AM - 11:10 AM

[E1662-1am-06] Development of tyrosinase-based proximity protein labeling in living cells

^○Yuna Matsuda¹, Hao Zhu¹, Jae Hoon Oh², Hideki Nakamura^1,2, Muneo Tsujikawa², Tomonori Tamura¹, Itaru Hamachi^1,2 (1. Graduate School of Engineering, Kyoto University, 2. JST ERATO)

[Lang.] Japanese

11:10 AM - 11:30 AM

[E1662-1am-07] Relationships between catalyst-promoted oxygenation level of amyloid β and cytotoxicity

^○Ryota Matsukawa¹, Masahiro Furuta¹, Harunobu Mitsunuma^1,2, Shigehiro Kawashima¹, Youhei Sohma³, Motomu Kanai¹ (1. Grad. Sch. Pharm. Sci., Tokyo Univ., 2. JST PRESTO, 3. Sch. Pharm. Sci., Wakayama Med. Univ.)

[Lang.] Japanese

Academic Program [Oral B]

[D1443-1pm] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 2:00 PM - 3:40 PM D1443 (1443, Bldg. 14 [4F])

Chair: Shuhei Higashibayashi, Toshitaka Okamura

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2:00 PM - 2:20 PM

[D1443-1pm-01] Stereochemical assignment of macrolide natural products by GIAO NMR calculation and DP4+ analysis

^○Keisuke Murata¹, Hirotoshi Mori¹, Haruhiko Fuwa¹ (1. Chuo University)

[Lang.] Japanese

2:20 PM - 2:40 PM

[D1443-1pm-02] Total Synthesis of Lobatamides

^○Soichiro Yasui¹, Shona Banjo¹, Yoshiyuki Nagashima¹, Yuto Okada¹, Eiko Nakasuji¹, Keisuke Nakata¹, Noritaka Chida¹, Toshitaka Okamura¹, Takaaki Sato¹ (1. Keio University)

[Lang.] English

2:40 PM - 3:00 PM

[D1443-1pm-03] Isolation and Structure Elucidation of Cytotoxic Substances from Marine Mollusk Aplysia kurodai and Elucidation of their Origins

^○Yusuke Hioki¹, Eri Anshita², Tatsuya Sato³, Toyoki Iwao⁴, Atsushi Kawamura^1,5, Tsunematsu Yuta^1,6, Masaki Kita¹ (1. Graduate School of Bioagricultural Sciences, Nagoya University, 2. School of Agricultural Sciences, Nagoya University, 3. Zakko Club, 4. Toba Fisheries Science Center, 5. Interdisciplinary Cluster for Cutting Edge Research, Shinshu University, 6. Institute for Advanced Research, Nagoya University)

[Lang.] English

3:00 PM - 3:20 PM

[D1443-1pm-04] Development and mechanistic studies of photo-mediated [4+2] cycloaddition for rapid assembly of iboga-type scaffold

^○Gavin Tay¹, Soushi Nishimura¹, Hiroki Kubota¹, Hiroki Oguri¹ (1. The University of Tokyo )

[Lang.] English

3:20 PM - 3:40 PM

[D1443-1pm-05] Syntheses of tricyclic diterpenes based on site-selective iodination and selective 6-endo radical cyclization

^○Riichi Hashimoto¹, Kengo Hanaya¹, Shuhei Higashibayashi¹, Takeshi Sugai¹ (1. Keio university)

[Lang.] English

Academic Program [Oral B]

[E1662-1pm] 16. Natural Products Chemistry, Chemical Biology

Wed. Mar 22, 2023 2:20 PM - 3:40 PM E1662 (1612, Bldg. 16 [1F])

Chair: Daisuke Takahashi, Gosuke Hayashi

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2:20 PM - 2:40 PM

[E1662-1pm-01] Efficient Synthesis of Tag-Modified Peptide Thioester Facilitated by γ-Substituted Proline

^○Koki Nakatsu¹, Gosuke Hayashi¹, Hiroshi Murakami^1,2 (1. Graduate School of Engineering, Nagoya Univ., 2. Institute of Nano-Life-Systems, Nagoya Univ.)

[Lang.] English

2:40 PM - 3:00 PM

[E1662-1pm-02] Stereospecific syntheses of aryl C-glycosides with glycosyl trifluoroborate

^○Kazuki Kurahayashi¹, Kengo Hanaya¹, Takeshi Sugai¹, Go Hirai², Shuhei Higashibayashi¹ (1. Fac. Pharm., Keio Univ., 2. Grad. Sch. Pharm. Sci., Kyushu Univ.)

[Lang.] English

3:00 PM - 3:20 PM

[E1662-1pm-03] Regio- and Stereoselective β-Arabinofuranosylation Using a Boron-Mediated Aglycon Delivery Method

^○Kazuki Inaba¹, Yuna Naito¹, Mina Tachibana¹, Kazunobu Toshima¹, Daisuke Takahashi¹ (1. Keio University)

[Lang.] English

3:20 PM - 3:40 PM

[E1662-1pm-04] Chemical synthesis of ganglioside TACAs and their conjugation to alpha-galactosyl ceramide for cancer vaccine constructs

^○Mads Hartvig Clausen¹ (1. Technical University of Denmark)

[Lang.] English

Academic Program [Oral B]

[D1443-2am] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 9:00 AM - 11:10 AM D1443 (1443, Bldg. 14 [4F])

Chair: Akihiro Ogura, Chikara Dohno

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9:00 AM - 9:20 AM

[D1443-2am-01] Bioconjugation of Au₂₅ nanocluster to trastuzumab

^○Katarzyna Joanna Malawska¹, Shinjiro Takano², Kounosuke Oisaki⁴, Haruaki Yanagisawa³, Masahide Kikkawa³, Tatsuya Tsukuda², Motomu Kanai¹ (1. Grad. Sch. Pharm. Sci., The Univ. of Tokyo, 2. Grad. Sch. Sci., The Univ. of Tokyo, 3. Grad. Sch. Med., The Univ. of Tokyo, 4. IRC3, AIST)

[Lang.] English

9:20 AM - 9:40 AM

[D1443-2am-02] Chemical reaction-driven “organ-to-organ” transfer of glycan-modified-HSA in living mouse

^○Kenshiro Yamada¹, Tatsuya Kobayashi¹, Akari Mukaimine², Ambara Rachmat PRADIPTA¹, Katsunori Tanaka^1,2 (1. Tokyo Institute of Technology,School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] English

9:40 AM - 10:00 AM

[D1443-2am-03] Development of novel psoralen-introduced triplex-forming oligonucleotides for the expansion of their target genome sequences

^○Yu Mikame¹, Honoka Eshima¹, Juki Nakao¹, Tsuyoshi Yamamoto¹, Yoshiyuki Hari², Chikara Dohno³, Takehiko Wada⁴, Asako Yamayoshi¹ (1. Grad. Sch. Biomed. Sci., Nagasaki Univ, 2. Fac. of Pharm. Sci., Tokushima Bunri University, 3. SANKEN., Osaka Univ, 4. IMRAM., Tohoku Univ)

[Lang.] Japanese

Break （10:00 AM - 10:10 AM）

10:10 AM - 10:30 AM

[D1443-2am-04] Development of fluorescent probes for selective detection of intracellular free magnesium ion

^○Akihiro Sakama¹, Rei Kumada¹, Yutaka Shindo¹, Naoko Iwasawa¹, Daniel Citterio¹, Kotaro Oka¹, Yuki Hiruta¹ (1. Keio University)

[Lang.] Japanese

10:30 AM - 10:50 AM

[D1443-2am-05] Control of RNA repeat foci formation by photoswitchable RNA binding ligands

^○Yusuke Fujiwara^1,2, Tomonori Shibata^1,2, Chikara Dohno^1,2, Kazuhiko Nakatani^1,2 (1. SANKEN, Osaka University, 2. CREST, JST)

[Lang.] Japanese

10:50 AM - 11:10 AM

[D1443-2am-06] Targeted α-ray therapy using the reaction between acrolein and azide

^○Yudai Ode¹, Ambara Rachmat PRADIPTA¹, Katsunori TANAKA^1,2 (1. Tokyo Institute of Technology, School of Materials and Chemical Technology, Department of Chemical Science and Engineering, 2. RIKEN Cluster for Pioneering Research, Biofunctional Synthetic Chemistry Laboratory)

[Lang.] English

Academic Program [Oral B]

[D1443-2pm] 16. Natural Products Chemistry, Chemical Biology

Thu. Mar 23, 2023 2:00 PM - 3:40 PM D1443 (1443, Bldg. 14 [4F])

Chair: Shoji Kobayashi, Takaaki Mitsuhashi

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2:00 PM - 2:20 PM

[D1443-2pm-01] Study on enantio-selective enzymatic halocyclization using the CS method

^○Takaaki Mitsuhashi¹, Jiazhuo Chen^2,1, Makoto Fujita^2,1 (1. IMS, 2. The Univ. of Tokyo)

[Lang.] Japanese

2:20 PM - 2:40 PM

[D1443-2pm-02] Functional and structural analysis of the terpene synthase found from the genome of giant virus

^○Youngcheol Jung¹, Takaaki Mitsuhashi², Miki Senda³, Sota Sato¹, Toshiya Senda³, Makoto Fujita^1,2 (1. Graduate School of Engineering, The Univ. of Tokyo, 2. Institute for Molecular Science, 3. High Energy Accelerator Research Organization)

[Lang.] English

2:40 PM - 3:00 PM

[D1443-2pm-03] Synthetic study of oxidative metabolites in mushrooms starting from ergosterol

^○Edric Wilbert¹, Saki Nagayasu¹, Tomoka Taguri¹, Shoji Kobayashi¹ (1. Osaka Institute of Technology)

[Lang.] English

3:00 PM - 3:20 PM

[D1443-2pm-04] Development of anti-HBV agents through divergent and programmable synthesis of skeletally diverse alkaloidal scaffolds bearing Michael acceptors

^○Nobuto Kaneko¹, Hiroki Kubota², Misao Himeno¹, Taketomo Kido¹, Atsushi Miyajima¹, Hiroki Oguri¹ (1. The University of Tokyo, 2. Tokyo University of Agriculture and Technology)

[Lang.] English

3:20 PM - 3:40 PM

[D1443-2pm-05] Development of Catalytic Asymmetric Mukaiyama-Michael Reaction and Its Application to Enantioselective Total Synthesis of Sesquiterpene Lactones

^○Ryoji Sugiyama¹, Masahisa Nakada¹ (1. Waseda University)

[Lang.] Japanese

Academic Program [Oral B]

[D1443-3am] 16. Natural Products Chemistry, Chemical Biology

Fri. Mar 24, 2023 9:00 AM - 10:00 AM D1443 (1443, Bldg. 14 [4F])

Chair: Atsushi Shimoyama, Daisuke Takahashi

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9:00 AM - 9:20 AM

[D1443-3am-01] Posttranslational glycan modification in Thermococcus kodakarensis: discovery and synthesis of myo-inositol containing N-glycan

^○Kohtaro Hirao¹, Yoshiyuki Manabe^1,2, Koichi Fukase^1,2 (1. Graduate School of Science, Osaka University, 2. Forefront Research Center, Osaka University)

[Lang.] English

9:20 AM - 9:40 AM

[D1443-3am-02] Synthesis of acetic acid bacteria Acetobacter pasteurianus lipid A

^○Haruki Yamaura¹, Atsushi Shimoyama¹, Koichi Fukase¹ (1. Osaka university)

[Lang.] English

9:40 AM - 10:00 AM

[D1443-3am-03] Synthetic Study in Dendritic Glycosylation Contributing to Assembly of Diverse High-mannose-type Glycan Library

^○Ruchio Usui¹, Megumi Kabasawa¹, Taiki Kuribara¹, Kiichiro Totani¹ (1. Seikei University)

[Lang.] English

Sessions

16. Natural Products Chemistry, Chemical Biology » Oral B

[E1662-1am] 16. Natural Products Chemistry, Chemical Biology

[E1662-1am-01] Total synthesis of pigments with azulene skeleton in an edible blue mushroom

[E1662-1am-02] Δ⁴-dinor-OPDAs, novel ancestral jasmonates of Marchantia polymorpha

[E1662-1am-03] JA-Ile-lactone enhanced accumulation of alkaloid in tomato

[E1662-1am-04] Chemical regulation of crosstalk between jasmonate and ethylene by peptide-based chemical tools

[E1662-1am-05] Glycolipids as ligands and molecular probes for C-type lectin receptor Mincle; synthesis and biological functional analysis

[E1662-1am-06] Development of tyrosinase-based proximity protein labeling in living cells

[E1662-1am-07] Relationships between catalyst-promoted oxygenation level of amyloid β and cytotoxicity

[D1443-1pm] 16. Natural Products Chemistry, Chemical Biology

[D1443-1pm-01] Stereochemical assignment of macrolide natural products by GIAO NMR calculation and DP4+ analysis

[D1443-1pm-02] Total Synthesis of Lobatamides

[D1443-1pm-03] Isolation and Structure Elucidation of Cytotoxic Substances from Marine Mollusk Aplysia kurodai and Elucidation of their Origins

[D1443-1pm-04] Development and mechanistic studies of photo-mediated [4+2] cycloaddition for rapid assembly of iboga-type scaffold

[D1443-1pm-05] Syntheses of tricyclic diterpenes based on site-selective iodination and selective 6-endo radical cyclization

[E1662-1pm] 16. Natural Products Chemistry, Chemical Biology

[E1662-1pm-01] Efficient Synthesis of Tag-Modified Peptide Thioester Facilitated by γ-Substituted Proline

[E1662-1pm-02] Stereospecific syntheses of aryl C-glycosides with glycosyl trifluoroborate

[E1662-1pm-03] Regio- and Stereoselective β-Arabinofuranosylation Using a Boron-Mediated Aglycon Delivery Method

[E1662-1pm-04] Chemical synthesis of ganglioside TACAs and their conjugation to alpha-galactosyl ceramide for cancer vaccine constructs

[D1443-2am] 16. Natural Products Chemistry, Chemical Biology

[D1443-2am-01] Bioconjugation of Au₂₅ nanocluster to trastuzumab

[D1443-2am-02] Chemical reaction-driven “organ-to-organ” transfer of glycan-modified-HSA in living mouse

[D1443-2am-03] Development of novel psoralen-introduced triplex-forming oligonucleotides for the expansion of their target genome sequences

[D1443-2am-04] Development of fluorescent probes for selective detection of intracellular free magnesium ion

[D1443-2am-05] Control of RNA repeat foci formation by photoswitchable RNA binding ligands

[D1443-2am-06] Targeted α-ray therapy using the reaction between acrolein and azide

[D1443-2pm] 16. Natural Products Chemistry, Chemical Biology

[D1443-2pm-01] Study on enantio-selective enzymatic halocyclization using the CS method

[D1443-2pm-02] Functional and structural analysis of the terpene synthase found from the genome of giant virus

[D1443-2pm-03] Synthetic study of oxidative metabolites in mushrooms starting from ergosterol

[D1443-2pm-04] Development of anti-HBV agents through divergent and programmable synthesis of skeletally diverse alkaloidal scaffolds bearing Michael acceptors

[D1443-2pm-05] Development of Catalytic Asymmetric Mukaiyama-Michael Reaction and Its Application to Enantioselective Total Synthesis of Sesquiterpene Lactones

[D1443-3am] 16. Natural Products Chemistry, Chemical Biology

[D1443-3am-01] Posttranslational glycan modification in Thermococcus kodakarensis: discovery and synthesis of myo-inositol containing N-glycan

[D1443-3am-02] Synthesis of acetic acid bacteria Acetobacter pasteurianus lipid A

[D1443-3am-03] Synthetic Study in Dendritic Glycosylation Contributing to Assembly of Diverse High-mannose-type Glycan Library

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