*Nyein Chan Soe^1,2, Takamitsu Ohigashi³, Hokuto Nakata¹, Chikae Tatsumi³, Yoshitaka Uchida⁴, Walubita Mufalo⁵, Mayumi Ito⁶, Tsutomu Sato⁶, Toshifumi Igarashi⁶, Yared B Yohannes^1,7, Yoshinori Ikenaka^1,8,9,10, Mayumi Ishizuka¹, Shouta MM NAKAYAMA^1,11 (1.Laboratory of Toxicology, Department of Environmental Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, 060-0818, Japan, 2.Department of Pharmacology and Parasitology, University of Veterinary Science, Yezin, Nay Pyi Taw, 15013, Myanmar, 3.Graduate School of Global Food Resources, Hokkaido University, Sapporo, 060-8589, Japan, 4.Global Center for Food, Land and Water Resources, Research Faculty of Agriculture, Hokkaido University, Sapporo, 060- 8589, Japan, 5.Graduate School of Engineering, Hokkaido University, Sapporo, 060- 8628, Japan, 6.Faculty of Engineering, Hokkaido University, Sapporo, 060- 8628, Japan, 7.Department of Chemistry, College of Natural and Computational Science, University of Gondar, Ethiopia, 8.Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, 060-0818, Japan , 9.One Health Research Center, Hokkaido University, Japan, 10.Water Research Group, School of Environmental Sciences and Development, North-West University, South Africa, 11.Biomedical Sciences Department, School of Veterinary Medicine, The University of Zambia, P.O. Box 32379, Lusaka 10101, Zambia)