[2Gp01-04] Soft matter/Biomaterial (SO/BI)

[2Gp02] Simulation and modeling of artificial bilayer lipid membranes under the voltage-clamp conditions

*Yoshikazu Shimada^1,2, Hironori Kageyama^2,3, Teng Ma^4,5, Hideaki Yamamoto², Ayumi Hirano-Iwata^1,2,3,4 (1. Graduate School of Engineering, Tohoku University, 2. Research Institute of Electrical Communication, Tohoku University, 3. Graduate School of Biomedical Engineering, Tohoku University, 4. Advanced Institute for Material Research, Tohoku University, 5. Beijing Institute of Technology, China)

All cells in our body are covered by cell membranes that are composed of lipid bilayer and membrane proteins. The lipid bilayer can be artificially formed and is widely used as a model cell membrane system. We have reported stable artificial lipid bilayer and proposed them as a membrane platform for evaluating the functions of the membrane proteins, especially ion channels. Recently, we have constructed a membrane system in which a lateral voltage can be applied in addition to a conventional transmembrane voltage. The lateral voltage effectively enhanced the transmembrane current in ion-channel-incorporated lipid bilayer systems. However, the working mechanism of the lateral voltage to increase the channel activities has not yet been clarified. In this study, we constructed a simulation model of an artificial membrane platform using continuum modeling and simulated the effect of the lateral voltage on the membrane properties of lipid bilayer.