Session information

Symposium

[S29] Supersulfides in environmental toxicology and hygiene

Sun. Mar 26, 2023 4:00 PM - 6:00 PM [Room HS1] (1F)

Organizer: Takashi Toyama, Kazuhiro Nishiyama

Intrinsically produced supersulfur molecules (supersulfides), in which sulfur atoms are continuously bonded, have recently attracted attention for their physiological effects. It has been pointed out that supersulfation of cysteine increases the reactivity of thiol groups and may increase antioxidant activity and reactivity with medicinal toxicants, and may be an important regulatory factor, especially in toxicity and cell death caused by redox imbalance in vivo. Although it is well known that supersulfur is involved in various biological phenomena and pathological phenomena such as inflammation, this symposium will bring together young researchers in redox toxicology, hygienic pharmacology, and dynamics analysis of supersulfur in particular to discuss the significance of supersulfur. We will also present the latest findings on the unique pathways of supersulfur production in vivo. Through this symposium, we hope to renew the existing understanding of the role of transsulfur in toxicology and to deepen our understanding of the potential for new research developments.

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オーガナイザー挨拶：外山喬士（東北大院薬） (4:00 PM - 4:10 PM)

4:10 PM - 4:35 PM

[S29-01] The role of supersulfide in methylmercury detoxification

○Takashi Toyama¹, Runa Kudo¹, Yoshiro Saito¹ (1. Grad.Sch.Pharm.,Tohoku Univ.)

4:35 PM - 5:00 PM

[S29-02] Supersulfides to regulate electrophilic stress

○Masahiro Akiyama^1,2, Jun Uchiyama¹, Yoshito Kumagai², Yun-Gi Kim¹ (1. Faculty of Pharmacy, Keio Univ., 2. Faculty of Medicine, Univ. of Tsukuba)

5:00 PM - 5:25 PM

[S29-03] Characterization of Supersulfide in Serum Albumin and its Therapeutic Application

○Mayumi Ikeda^1,2, Tatsuya Fukuta¹, Yasunori Iwao¹, Masaki Otagiri³, Toru Maruyama⁴, Tatsuhiro Ishida², Yu Ishima² (1. Wakayama Medical Univ., 2. Tokushima Univ., 3. Sojo Univ., 4. Kumamoto Univ.)

5:25 PM - 5:50 PM

[S29-04] Redox biology involved in the toxicity of Enterohemorrhagic Escherichia coli toxin SubAB

○Hiroyasu Tsutsuki¹, Tianli Zhang¹, Kinnosuke Yahiro², Takaaki Akaike³, Tomohiro Sawa¹ (1. Dept. Microbiol., Grad. Sch. Med. Sci., Kumamoto Univ., 2. Dept. Microbiol. Infect. Cont. Sci, Kyoto Pharm. Univ., 3. Dept. Environ. Med. Mol. Toxicol., Tohoku Univ. Grad. Sch. Med.)