Structure and solubility, passive diffusivity, cell membrane permeability, and P-gp substrate properties of optically active cyclopropane-containing cyclic peptides.<strong></strong>

○Hiroyuki Miyachi

[27P1-pm2-112] Structure and solubility, passive diffusivity, cell membrane permeability, and P-gp substrate properties of optically active cyclopropane-containing cyclic peptides.

○Hiroyuki Miyachi¹, Kayoko Kanamitsu¹, Mayumi Ishii¹, Eri Watanabe¹, Yukina Sato², Takayuki Osada², Yuuki Yamazaki², Hitoshi Kashiwagi², Mitsuru Sugawara², Satoshi Shuto², Yasuteru Shigeta³, Mizuki Watanabe², Katsumi Maenaka² (1. DDI, Grad. Sch. Pharm. Sci., TOKYO university, 2. Grad. Sch. Pharm. Sci., HOKKAIDO university, 3. Cent. comp. Sci., TSUKUBA Univ)

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Presentation information

[27P1-pm2] Chemical biology/Drug design/Natural medicines and biological products/Pharmacologically active compounds/Structure-activity relationship/Others

[27P1-pm2-112] Structure and solubility, passive diffusivity, cell membrane permeability, and P-gp substrate properties of optically active cyclopropane-containing cyclic peptides.

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