[4T18L-11(3P1088)] Innovative therapeutic strategy for aggressive MYCN-amplified neuroblastoma using PI polyamide-drug conjugate

〇Hiroyuki Yoda^1,2, Atsushi Takatori¹, Takahiro Inoue^1,2, Takayoshi Watanabe¹, Nobuko Koshikawa¹, Toshinori Ozaki³, Hiroki Nagase¹ (1.Div. Cancer Genet., Chiba Cancer Ctr. Res. Inst., 2.Dep. Mol. Biol. & Oncol., Grad. Sch. Med. & Pharm. Sci., Chiba Univ., 3.Div. DNA Damage Signaling, Chiba Cancer Ctr. Res. Inst.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 1:25 PM - 1:35 PM

[4T18L-12(3P1089)] Molecular design of highly selective peptide inhibitors against MMP-14

〇Yuta Sasaki¹, Shouichi Higashi¹ (1.Grad. Sch. Nanobiosci., Yokohama city Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 1:35 PM - 1:45 PM

[4T18L-13(3P1090)] Anticancer activities of DNA-alkylating Pyrrole-Imidazole polyamide conjugate targeting mutant KRAS

〇Kiriko Hiraoka¹, Takahiro Inoue¹, Hiroyuki Yoda¹, Sakthisri Krishnamurthy¹, Jason Lin¹, Takayoshi Watanabe¹, Atsushi Takatori¹, Nobuko Koshikawa¹, Toshikazu Bando³, Hiroshi Sugiyama³, Toshinori Ozaki², Hiroki Nagase¹ (1.Lab. Cancer Genetics, Chiba Cancer Centr. Res. Inst., 2.Lab. DNA Damage Signaling, Chiba Cancer Centr. Res. Inst., 3.Dep. Chem., Grad. Sch. Sci., Univ. Kyoto)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 1:45 PM - 1:55 PM

[4T特L-01(3P1192)] Restriction of protein synthesis abolishes senescence features at cellular and organismal levels

〇Yuki Takauji¹, Takumi Wada¹, Asuka Takeda¹, Ikuru Kudo¹, Kensuke Miki^1,2, Michihiko Fujii¹, Dai Ayusawa^1,2 (1.Grad. Sch. of Nanobiosci., Yokohama City Univ., 2.Ichiban Life Corp.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 11:45 AM - 11:55 AM

[4T特L-02(3P1193)] SMARCD1 regulates hepatic functions

〇Tomomi Kozaki¹, Chisato Inoue¹, Yumi Tsuduki¹, Miyako Udono¹, Yoshinori Katakura² (1.Grad. Sch. Biores. Bioenv. Sci.,Univ.of Kyushu, 2.Fac. Agri.,Univ of Kyushu)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 11:55 AM - 12:05 PM

[4T特L-03(3P1194)] Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.

〇Yukimasa Takeda¹, Hong Soon Kang¹, Fred B. Lih², Hongfeng Jiang³, William S. Blaner³, Anton M. Jetten¹ (1.Cell Biology Section, NIEHS, NIH, 2.Mass Spectrometry Group, NIEHS, NIH, 3.Dept. of Med., Columbia Univ.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 12:05 PM - 12:15 PM

[4T特L-04(3P1195)] The role of hepatic molecular clock in pathophysiology of NASH

〇Taira Wada¹, Kenshin Yoshida¹, Chizuru Yamashita¹, Shigeki Shimba¹ (1.Sch. of Pharm., Univ. of Nihon)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 12:15 PM - 12:25 PM

[4T特L-05(3P1196)] Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells

〇Shinichiro Takebayashi^1,2, Hiroshi Tanaka¹, Yuko Nakatsu¹, Tomoka Igata¹, Mitsuyoshi Nakao¹ (1.Dept. of Med. Cell Biol., IMEG, Kumamoto Univ., 2.Dept. of Biochem. & Proteomics, Grad. Sch. of Med., Mie University)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 12:25 PM - 12:35 PM

[4T特L-06(3P1197)] A novel pathway of energy metabolism by neuronal Ca²⁺ sensor-1

〇Tomoe Y Nakamura - Nishitani¹, Shu Nakao¹, Osamu Nakagawa¹, Shigeo Wakabayashi² (1.Dept. of Mol. Physiol., Natl. Cer. Cardiovasc. Ctr., 2.Dept. of Cardi. Physiol., Natl. Cer. Cardiovasc. Ctr.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 12:35 PM - 12:45 PM

[4T特L-07(3P1198)] VAMP7 regulates autophagy to maintain mitochondrial homeostasis and 2nd phase insulin secretion in pancreatic beta-cells

〇Kyota Aoyagi¹, Mica Ohara-Imaizumi¹, Makoto Itakura², Seiji Torii³, Yoshihiro Akimoto⁵, Chiyono Nishiwaki¹, Yoko Nakamichi¹, Takuma Kishimoto¹, Akihiro Harada⁴, Masami Takahashi², Shinya Nagamatsu¹ (1.Dept. of Biochem., Kyorin Univ. Sch. of Med., 2.Dept. of Biochem., Kitasato Univ. Sch. of Med., 3.Biosignal Res. Center, Inst. for Mol. and Cellular Regulation, Gunma Univ., 4.Dept. of Cell Biol., Grad. Sch. of Med., Osaka Univ., 5.Dept. of Anatomy, Kyorin Univ. Sch. of Med.)

BMB2015 Biochemistry and Molecular Biology |Fri. Dec 4, 2015 12:45 PM - 12:55 PM