[3P1253] Novel small molecules identified by in silico screening induce TrkB activation and decrease depression-like behavior in mice

〇Mayu Fukuda^1,4, Atsushi Takatori^1,2, Yohko Nakamura^1,3, Akiko Suganami⁵, Tyuji Hoshino⁶, Yutaka Tamura⁵, Akira Nakagawara⁷, Masatoshi Tagawa⁸ (1.Div. of Innovative Cancer Therapeutics, Chiba Cancer Ctr. Res. Inst., 2.Div. of Cancer Genetics, Chiba Cancer Ctr. Res. Inst., 3.Div. of Cancer Prevention and Epidemiology, Chiba Cancer Ctr. Res. Inst., 4.Grad. Sch. of Med. and Pharmaceutical Sciences, Chiba Univ., 5.Dept. of Bioinformatics, Grad. Sch. of Med., Chiba Univ., 6.Grad. Sch. of Pharmaceutical Sciences, Chiba Univ., 7.Saga Medical Ctr. KOSEIKAN, 8.Div. of Cell Therapy, Chiba Cancer Ctr. Res. Inst.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1254] Neuronal stress and alcohol dependence regulated by ULK1

〇Keisho Ueta¹, Akiko Sumitomo¹, Kouta Horike¹, Sayaka Mauchi¹, Takatoshi Hikida¹, Akira Sawa², Toshifumi Tomoda¹ (1.MIC, Grad. Sch. of Med., Kyoto Univ., 2.Dept. of Psychiatry, Johns Hopkins Univ. Sch. of Med.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1255] APP receives O-GalNAc glycan modification to facilitate amyloid-β production

〇Yuriko Tachida¹, Shinobu Kitazume¹, Yasuhiko Kizuka¹, Ayako Kurimoto¹, Katsunori Tanaka², Naoyuki Taniguchi¹ (1.Disease Glycomics Team , Global Research Cluster,RIKEN, 2.Biofunctional Synthetic Chemistry Laboratory, RIKEN)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1256] Poly(I:C) stimulation-induced microglial activation is regulated by Nucling signal

〇Tuan Anh Pham¹, Takashi Sakai^1,2, Huy Van Dang¹, Yuji Shishido³, Yorita Kazuko¹, Kiyoshi Fukui^1,3 (1.Division of Enzyme Pathophysiology, The Institute for Enzyme Research (KOSOKEN), Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan, 2.The Institute for Health Sciences, Tokushima Bunri University, 180 Nishiham-mouji, Yamashiro-cho, Tokushima, 770-8514, Japan, 3.Division of Enzyme Literacy, Institute for Enzyme Research, Tokushima University, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1257] β- secretase deficient mice is associated with the development of the mammary gland

〇Yoshihiro Nishida¹, Miki Ohta-Nakamura², Hirokazu Kitamura³, Masakazu Chiba⁴, Hanae Yamamoto¹, Hisashi Narahara¹, Toshikatsu Hanada², Ryoji Hamanaka⁵ (1.Dept. of Obstetrics and Gycecology, Faculty of Med., Oita Univ., 2.Dept. of Cell Biology, Faculty of Med., Oita Univ., 3.Dept. of Matrix Med., Faculty of Med., Oita Univ., 4.Dept. of Molecular Anatomy, Faculty of Med., Oita Univ., 5.Dept. of Health Science, Oita Univ. of Nursing and Health Sciences)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1258(4T18p-02)] Heritability estimates of fracture risk in Thoroughbred racehorses

〇Teruaki Tozaki¹, Takeshi Miyake², Hironaga Kakoi¹, Kei-ichi Hirota¹, Shun-ichi Nagata¹ (1.Lab. of Racing Chem., 2.Comp. Agric. Sci., Grad. Agric. Sci., Kyoto Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1259(4T18p-03)] Structural and functional impacts of mutations causing Barth syndrome and alternative splicing in the Tafazzin acyltransferase domain

〇Atsushi Hijikata¹, Kei Yura², Osamu Ohara^3,4, Mitiko Go^1,5,6 (1.Nagahama Inst. Bio-Sci. and Tech., 2.Grad. Sch. of Hum. and Sci., Ochanomizu Univ., 3.Kazusa DNA Res. Inst., 4.RIKEN, IMS, 5.ROIS, 6.Nagoya Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1260(4T18p-04)] Design and application of expanded exome capture sequencing for the rat

〇Minako Yoshihara¹, Osamu Ohara², Takashi Kuramoto³, Mikita Suyama¹ (1.Div. of Bioinfo., med. Ins. of Bioregul., Kyuhsu Univ., 2.Lab. for Integ. Geno., RIKEN Center for Integ. Med. Sci.,, 3.Lab. Anim. Sci., Grad. Sch. of Medic., Kyoto Univ.)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1261(4T18p-05)] Generation of Transmitochondrial Mice Harboring Mitochondrial DNA-coded tRNA Pathogenic Mutation

〇Akinori Shimizu¹, Takayuki Mito², Shunkei Enoki¹, Emi Ogasawara², Osamu Hashizume², Ruriko Nagashima¹, Kaori Ishikawa², Kazuto Nakada^1,2, Jun-Ichi Hayashi² (1.Grad. Sch. of Life and Envir. Sci., Univ. of Tsukuba, 2.Fac. of Life and Envir. Sci., Univ. of Tsukuba)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM

[3P1262(4T18p-06)] Prevalence of germline mutations in patients with breast and ovarian cancer using multiple hereditary cancer gene panel

〇Yosuke Hirotsu¹, Hiroshi Nakagomi², Ikuko Sakamoto³, Hitoshi Mochizuki^1,4, Masao Omata^1,4,5 (1.Genome Analysis Center, Yamanashi Pref. Central Hosp., 2.Dept. of Breast Surgery, Yamanashi Pref. Central Hosp., 3.Dept. of Gynecology, Yamanashi Pref. Central Hosp., 4.Dept. of Gastroenterology, Yamanashi Pref. Central Hosp., 5.Univ. of Tokyo)

BMB2015 Biochemistry and Molecular Biology |Thu. Dec 3, 2015 4:45 PM - 6:45 PM