[P-585(3Z10-01)] Generation and Characterization of model mice carrying a pathogenic mtDNA mutation

^○Haruna Tani¹, Kaori Ishikawa^1,2, Jun-Ichi Hayashi³, Kazuto Nakada^1,2 (1.Graduate School of Life and Environmental Sciences, University of Tsukuba, 2.Faculty of Life and Environmental Sciences, University of Tsukuba, 3.Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance)

The 93rd Annual Meeting of JBS

[P-586] Hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

^○Yu Toyoda, Tappei Takada, Yoshihide Yamanashi, Hiroshi Suzuki (Dep. Pharm., Univ. Tokyo Hosp.)

The 93rd Annual Meeting of JBS

[P-587(3Z10-02)] Analysis of genes highly expressed in mature beta-cells of pancreas.

^○Wataru Nishimura, Munkhtuya Tumurkhuu (Department of Molecular Biology, IUHW School of Medicine)

The 93rd Annual Meeting of JBS

[P-588] Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan

^○Aya Kitamoto¹, Takuya Kitamoto¹, Kikuko Hotta² (1.Advanced Research Facilities and Services, Preeminent Medical Photonics Education & Research Center, Hamamatsu University School of Medicine, 2.Department of Pharmacy, Osaka Ohtani University)

The 93rd Annual Meeting of JBS

[P-589(3Z10-03)] Measurement of Glucose dependent insulin secretion using "iGL cells"

^○Satoru Yokawa¹, Sachi Matsushita², Shinji Fukuda², Yoshikazu Inoh¹, Tadahide Furuno¹, Satoshi Inouye³, Takahiro Suzuki² (1.Sch. Pharm., Aichi Gakuin Univ., 2.Sch. Dent., Aichi Gakuin Univ., 3.JNC Co., Yokohama.)

The 93rd Annual Meeting of JBS

[P-590] The regulation of pancreatic-α cell function by HNF-1α

^○Yoshifumi Sato¹, Rahman Md Mostafizur¹, Masaki Haneda¹, Tomoya Mizumoto¹, Tomonori Tsuyama², Tatsuya Yoshizawa¹, Tadahiro Kitamura³, J Gonzalez Frank⁴, Ken-ichi Yamamura⁵, Kazuya Yamagata^1,2 (1.Department of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, 2.Center for Metabolic Regulation of Healthy Aging, 3.Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, 4.Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States, 5.Institute of Resource Development and Analysis, Kumamoto University)

The 93rd Annual Meeting of JBS

[P-591] Failure of mitochondrial quality control in giant islets induced by diabetic condition causes defective insulin secretion

^○Kyota Aoyagi¹, Shun-ichi Yamashita², Chiyono Nishiwaki¹, Yoko Nakamichi¹, Tomotake Kanki², Mica Ohara-Imaizumi¹ (1.Department of Cellular Biochemistry, Kyorin University School of Medicine, 2.Department of Cellular Physiology, Niigata University Graduate School of Medical and Dental Sciences)

The 93rd Annual Meeting of JBS

[P-592(3Z10-04)] Impaired glucose-stimulated insulin secretion in 5-aminolevulinate synthase 1 (ALAS1) gene knockout heterozygous mice

^○Kazuya Takeda^1,2, Koen van Wijk¹, Tomohiro Kimura¹, Satoshi Okano¹, Shinichi Saitho³, Hiroaki Yamaguchi², Ken Kodama⁴, Kiwamu Takahashi⁵, Tohru Tanaka⁵, Motowo Nakajima⁵, Osamu Nakajima¹ (1.Inst. for Promotion of Med.Sci. Res., Yamagata Univ. Sch. Med., 2.Dep. of Pharmacy, Yamagata Univ. Sch. Med., 3.Dep. of Immunol., Yamagata Univ. Sch. Med., 4.Neopharm Japan Co., Ltd., 5.SBI Pharmaceuticals Co., Ltd.)

The 93rd Annual Meeting of JBS

[P-593] Therapeutic Silencing of Centromere Protein X Ameliorates Hyperglycemia in Zebrafish and Mouse Models of Type 2 Diabetes Mellitus

^○Liqing Zang¹, Yasuhito Shimada², Hiroko Nakayama¹, Norihiro Nishimura¹ (1.Graduate School of Regional Innovation Studies, Mie University, 2.Department of Integrative Pharmacology, Mie University Graduate School of Medicine)

The 93rd Annual Meeting of JBS

[P-594] Characterization of dominant mutations associated with intellectual disability in the ceramide transport protein-encoding CERT1 gene

Norito Tamura¹, Hiroaki Murakami², Kenji Kurosawa², ^○Kentaro Hanada¹ (1.Department of Biochemistry & Cell Biology, National Institute of Infectious Diseases, 2.Department of Genetics, Kanagawa Children's Medical Center)

The 93rd Annual Meeting of JBS