[P-686(2Z05-05)] Effect of aquaporin-4 on the clearance of extracellular tau and tau accumulation

^○Kazuhisa Ishida¹, Kaoru Yamada¹, Tadahumi Hashimoto¹, Yoichiro Abe², Masato Yasui², Takeshi Iwatsubo¹ (1.Department of Neuropathology, Graduate School of Medicine, The University of Tokyo, 2.Department of Pharmacology, Keio University School of Medicine)

The 93rd Annual Meeting of JBS

[P-687] Analysis of mitochondrial respiratory chain complex in amyotrophic lateral sclerosis model N2a cells

^○Wataru Murata, Ryosuke Amagai, Tsukasa Hara, Ryunosuke Hosoi, Shohei Hijikata, Ayako Okado-Matsumoto (Department of Biology, Faculty of Science, Toho University)

The 93rd Annual Meeting of JBS

[P-688] Identification of macrocyclic peptides that regulate the CD47-SIRPalpha system, and their potential as anti-cancer drugs

^○Yoji Murata¹, Daisuke Hazama¹, Yizhen Yin², Makoto Matsuda³, Takeshi Okamoto¹, Daisuke Tanaka¹, Mariko Sakamoto¹, Yuka Kakuchi¹, Naohiro Terasaka², Jinxuan Zhao², Yasuyuki Saito¹, Takenori Kotani¹, Atsushi Nakagawa³, Hiroaki Suga², Takashi Matozaki¹ (1.Div. Mol & Cell. Signal., Dep. Biochem. & Mol. Biol., Kobe Univ. Grad. Sch. Med., 2.Lab. Bioorg. Chem., Grad. Sch. Sci., Univ. Tokyo, 3.Lab. Supramol. Crystallogr., Inst. Protein Res., Osaka Univ.)

The 93rd Annual Meeting of JBS

[P-689] The antioxidant activity of Akita prefecture's biomass in HaCaT.

^○Tomonori Sato¹, Kenji Uehara¹, Shinji Kudo², Junnichiro Hayashi², Sho Shindo¹ (1.Akita Research Institute of Food & Brewing., 2.Institute for Materials Chemistry and Engineering, Kyushu University)

The 93rd Annual Meeting of JBS

[P-690] Screening of cell protectant on human epidermal keratinocyte toxicity by sorafenib

^○Yayoi Kamata^1,2, Mitsutoshi Tominaga^1,2, Kenji Takamori^1,2 (1.Inst. for Env. and Gen. Med, JIRC, Juntendo Univ. Grad.Sch.of Med., 2.Anti-Aging Skin Research Lab, Juntendo Univ. Grad.Sch.of Med.)

The 93rd Annual Meeting of JBS

[P-691] Determining therapeutic vulnerabilities in pancreatic cancer using a whole-animal platform

^○Masahiro Sonoshita (Div. Biomedical Oncology, Hokkaido University Institute for Genetic Medicine)

The 93rd Annual Meeting of JBS

[P-692] Screening of a novel aptamer that inhibits PCSK9/LDLR interaction by SELEX to develop an agent for hypercholesterolemia treatment

^○Takehiro Ando¹, Mizuki Yamamoto², Takumi Yokoyama¹, Daisuke Horiuchi¹, Yukio Takamori¹, Takashi Kawakami^1,2,3 (1.Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, University of Yamanashi, 2.Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, 3.JST, PRESTO)

The 93rd Annual Meeting of JBS

[P-693(2Z05-06)] Search for the inhibitors of GAS41, an epigenetic reader protein

^○Shohei Takase¹, Miho Takahashi^1,2, Takeshi Sonoda³, Masaki Kikuchi⁴, Yasumitsu Kondoh^5,6, Takashi Umehara⁴, Hiroyuki Osada^5,6, Minoru Yoshida^2,3,7, Akihiro Ito^1,2 (1.Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci., 2.Chem. Genomics Res. Gr., RIKEN CSRS, 3.Drug Discov. Seed Cpds. Explor. Unit, RIKEN CSRS, 4.Lab. for Epigenetics Drug Discov., RIKEN BDR, 5.Chem. Biol. Res. Gr., RIKEN CSRS, 6.Chem. Bank Unit Drug Discov., RIKEN CSRS, 7.Dept. Biotech. and CRIIM, Univ. Tokyo)

The 93rd Annual Meeting of JBS

[P-694] Development of novel peptide inhibitors for molecular targeted therapy of cancer by PURE system and mRNA display

^○Daisuke Horiuchi¹, Takehiro Ando¹, Takumi Yokoyama¹, Yukio Takamori¹, Mizuki Yamamoto², Takashi Kawakami^1,2,3 (1.Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, University of Yamanashi, 2.Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, University of Yamanashi, 3.JST, PRESTO)

The 93rd Annual Meeting of JBS

[P-695] Screening of novel peptide compounds by PURE system and mRNA display for treatment and diagnosis of dyslipidemia

^○Takumi Yokoyama¹, Takehiro Ando¹, Yukio Takamori¹, Daisuke Horiuchi¹, Mizuki Yamamoto², Takashi Kawakami^1,2,3 (1.Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, University of Yamanashi, 2.Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering and Agricultural Sciences, University of Yamanashi, 3.JST, PRESTO)

The 93rd Annual Meeting of JBS