[1P-534(1T15a-10)] GATA2 mutation accelerates hematopoietic stem cell aging

^〇Kaho Sato¹, Mikiko Suzuki^1,2,3, Erika Nomoto¹, Kokoro Nakamura¹, Toko Naganuma¹, Ikuo Hirano^1,2, Rituko Shimizu ^1,2 (1.Department of Molecular Hematology, Tohoku University Graduate School of Medicine, 2.Tohoku Medical Mega-Bank Organization, Tohoku University, 3.Center for Radioisotope Sciences, Tohoku University Graduate School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-535] Evaluation of the efficacy of RFFL antisense oligos in improving the function of cystic fibrosis-associated CFTR mutants.

^〇Daichi Hinata¹, Yukari Fukuda¹, Ryosuke Fukuda¹, Yuuya Kasahara², Satoshi Obika³, Tokuyuki Yoshida⁴, Takao Inoue⁴, Tsukasa Okiyoneda¹ (1.Department of Biomedical Sciences, School of Biological and Environmental Sciences, Kwansei Gakuin University, 2.National Institute of Biomedical Innovation,Health and Nutrition, 3.Graduate School of Pharmaceutical Sciences, Osaka University, 4.Division of Molecular Target and Gene Therapy Products, National Institute of Health Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-536] Molecular Mechanisms of Severe Liver Injury Associated with X-linked Myotubular Myopathy (XLMTM)

^〇Nobuyuki Shimizu¹, Hiroshi Shiraishi¹, Masanori Inoue², Kiyota Kyoko^1,2, Kenji Ihara², Toshikatsu Hanada¹ (1.Oita University Faculty of Medicine Department of Cell Biology, 2.Oita University Faculty of Medicine Department of Pediatrics)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-537] Correlation analysis of conformational alterations in ALS-linked SOD1 and clinical phenotypes

^〇Takao Fujisawa¹, Yurika Momozawa¹, Hisashi Noma², Hidenori Ichijo¹ (1.Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.Department of Data Science, The Institute of Statistical Mathematics)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-538] Nrf2 Activation Improves Experimental Rheumatoid Arthritis

^〇Anqi Zhang¹, Takafumi Suzuki¹, Saki Adachi¹, Eiki Yoshida¹, Masayuki Yamamoto^1,2 (1.Departments of Biochemistry and Molecular Biology, Tohoku Medical-Megabank Organization, Tohoku University, 2.The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-539] α2-antiplasmin is a key regulator of macrophage activation syndrome progression through modulation of IFN-γ-induced responses and fibrin deposition.

^〇Yosuke Kanno¹, Kinomi Toyama¹, Haruna Shibata¹, Osamu Matsuo², Kei-ichi Ozaki¹ (1.Department of Molecular Pathology, Faculty of Pharmaceutical Science, Doshisha Womens College of Liberal Arts, 2.Faculty of Medicine, Kindai University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-540] Senescence of alveolar epithelial cells promote lung fibrosis

^〇Yasuhiro Takenouchi¹, Keidai Unou¹, Keisuke Kitakaze¹, Rie Sugimoto¹, Hironobu Ishimaru¹, Kazuhito Tsuboi¹, Yasuo Okamoto¹ (Dept. Pharmacol., Kawasaki Med. Sch.)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-541] Anti-prion antibody treatment attenuates liver inflammation and fibrosis in experimental non-alcoholic steatohepatitis mouse model

^〇Junji Chida¹, Hideyuki Hara¹, Mayuko Simizu², Betzaya Batuluun¹, Koichi Tsuneyama², Suehiro Sakaguchi¹ (1.Division of Molecular Neurobiology, Institute of Advanced Medical Sciences (IAMS), Tokushima University, 2.Department of Pathology and Laboratory Medicine, Tokushima University Graduate School of Biomedical Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-542] Low-carbohydrate diets with plant-derived fat improve heart failure by increasing cardiac stearic acid and subsequent PPARα activation

^〇Satoshi Bujo¹, Haruhiro Toko¹, Kaoru Ito², Mutsuo Harada¹, Issei Komuro¹ (1.Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 2.Laboratory for Cardiovascular Genomics and Informatics, RIKEN Center for Integrative Medical Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-543] Development of a mouse model with cardio-renal pathological dysfunction in early phase

^〇Naoto Muromachi¹, Junji Ishida², Kazuyuki Noguchi², Akiyoshi Fukamizu² (1. Doctoral Program in Life and Agricultural Sciences, University of Tsukuba, 2.Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba)

The 96th Annual Meeting of the Japanese Biochemical Society