[1P-564] Nicotinic ACh receptor activation induces BACE1 transcription via MEK/ERK-SP1 signaling pathway

^〇Masaki Nakano¹, Yachiyo Mitsuishi¹, Masaki Nishimura¹ (Molecular Neuroscience Research Center, Shiga University of Medical Science)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-565] Theoretical analysis of dopamine chemical reaction network using structural bifurcation analysis

^〇Shun Sawada¹, Keiichiro Tokita¹ (Graduate school of Informatics,Nagoya University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-566] GPRC6A-mediated testosterone signaling induces microglial autophagy

^〇Haiyan Du¹, Akiko Mizokami², Takashi Kanematsu¹, Tomomi Sano¹, Yosuke Yamawaki³, Eijiro Jimi^2,4 (1.Department of Cell Biology, Aging Science, and Pharmacology, 2.OBT Research Center, 3.Department of Advanced Pharmacology, Daiichi University of Pharmacy, 4.Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Kyushu University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-567] A GPR34-selective agonist increases microglial uptake of Amyloid-β fibrils

^〇Hayato Etani¹, Sho Takatori¹, Aika Akahori¹, Junpei Ohmi², Junken Aoki², Tomohiko Ohwada³, Hirotaka Watanabe⁴, Hideyuki Okano⁴, Taisuke Tomita¹ (1.Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 3.Laboratory of Organic and Medicinal Chemistry, Graduate School of Pharamaceutical Sciences, The University of Tokyo, 4.Department of Physiology, Keio University School of Medicine)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-568] Roles of transthyretin commonly induced in the hippocampus of two depression mouse models

^〇Hidehito Saito-Takatsuji¹, Takayuki Ikeda¹, Yasuo Yoshitomi¹, Ryo Yomamoto², Takafumi Furuyama², Yasuhito Ishigaki³, Nobuo Kato², Hideto Yonekura¹ (1.Department of Biochemistry, Kanazawa Medical University School of Medicine, 2.Department of Physiology, Kanazawa Medical University School of Medicine, 3.Department of Life Science, Medical Research Institute, Kanazawa Medical University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-569] Three-dimensional neurite lesions in schizophrenia

^〇Kaede Shiga¹, Rino Saiga¹, Yoshiro Yamamoto², Susumu Takekoshi³, Chie Inomoto³, Naoya Nakamura³, Kenichi Oshima^4,5, Masanari Itokawa^4,5, Makoto Arai⁴, Youta Torii⁶, Itaru Kushima⁶, Shuji Iritani^6,7, Norio Ozaki⁶, Masahiro Yasutake⁸, Masayuki Uesugi⁸, Akihisa Takeuch⁸, Kentaro Uesugi⁸, Yasuko Terada⁸, Yoshio Suzuki ⁹, Viktor Nikitin ¹⁰, Vincent De Andrade¹⁰, Francesco De Carlo¹⁰, Ryuta Mizutani¹ (1.Grad Sch of Engineering, Tokai Univ , 2.Sch of Science, Tokai Univ, 3.Tokai Univ Sch of Medicine, 4.Tokyo Metropolitan Institute of Medical Sci, 5.Tokyo Metropolitan Matsuzawa Hospital, 6.Grad Sch of Medicine, Nagoya Univ, 7.Okehazama Hospital, 8.JASRI/SPring-8, 9.High Energy Accelerator Research Organization KEK, 10.Advanced Photon Source, Argonne Natl Lab)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-570] The role of LRRK2 in enteric neurogenesis and the pathogenesis of Parkinson'sdisease

^〇Tatsunori Maekawa¹, Rei Kawashima¹, Shun Tamaki¹, Akari Yamochi¹, Nonoka Misawa¹, Yukari Okubo¹, Narumi Ohta¹, Mayumi Uematsu¹, Yuri Yamada¹, Yusuke Hara¹, Takafumi Ichikawa¹ (Department of Biochemistry, School of Allied Health Sciences, Kitasato University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-571] Macroautophagy mediates secretion of the TDP-43-containing extracellular vesicles

^〇Yoshinori Tanaka¹, Shun-ichi Ito¹, Yuki Honma¹, Masato Hasegawa², Fuyuki Kametani², Genjiro Suzuki², Lina Kozuma¹, Kosuke Takeya¹, Masumi Eto¹ (1.Biochem. Unit, Fac. of Vet. Med., Okayama Univ. of Sci., 2.Dept. of Brain and Neurosci., TMIMS)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-572] Pathophysiological functions of CXCL10 in a mouse model of tauopathy.

^〇Ryohei Uenishi¹, Masanori Hijioka¹, Saito Takashi ¹ (Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University. Graduate School of Medical Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-573] Establishment of a tauopathy mouse model that can rapidly and easily induce tau aggregation

^〇Lisa Tatsumi¹, Sho Takatori¹, Taeko Kimura¹, Taisuke Tomita¹ (The University of Tokyo, Graduate School of Pharmaceutical Sciences)

The 96th Annual Meeting of the Japanese Biochemical Society