[1P-574] Functional analysis of iPS cell-derived astrocytes carrying Apolipoprotein E Christchurch variant against Alzheimer's disease pathology

^〇Rei Murakami¹, Hirotaka Watanabe¹, Tadafumi Hashimoto^2,3, Takeshi Iwatsubo², Hideyuki Okano¹ (1.Department of Physiology, Graduate School of Medicine Keio University, 2.Department of Neuropathology, Graduate School of Medicine The University of Tokyo, 3.Department of Degenerative Neurological Diseases, National Institute of Neuroscience National Center of Neurology and Psychiatry)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-575] LPA-induced Schwann cell dedifferentiation and demyelination-like changes are suppressed by a novel LPA1 receptor inhibitor

^〇Shizuka Takaku¹, Kousei Matsumoto², Kenji Nishikawa², Yasuhiro Aga², Kazunori Sango¹ (1.Diabetic Neuropathy Project, Tokyo Metropolitan Institute of Medical Science, 2.Pharmaceutical Research Laboratory, Pharmaceutical Division, UBE Corporation)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-576] Presenilin 1 deficiency impairs Aβ42-to-Aβ40-converting activity of ACE

^〇Kun Zou¹, Yuan Gao¹, Yang Sun¹, Sadequl Islam¹, Tomohisa Nakamura¹, Taisuke Tomita², Makoto Michikawa³ (1.Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, 2.Lab. of Neuropath. and Neurosci., Fac. of Pharm. Sci., Univ. of Tokyo, 3.School of Life Dentistry at Niigata, Nippon Dental University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-577] Identification of a novel pentosidine synthesis pathway associated with schizophrenia

^〇Kazuya Toriumi¹, Kyoka Iino¹, Azuna Ozawa¹, Mitsuhiro Miyashita^1,2, Kazuhiro Suzuki^1,3, Hikari Sugawa⁴, Koichi Tabata¹, Masanari Itokawa¹, Ryoji Nagai⁴, Hidenori Kamiguchi⁵, Makoto Arai¹ (1.Schizophrenia Research Project, Tokyo Metropolitan Institute of Medical Science, 2.Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 3.Department of Community Mental Health, School of Medicine, Shinshu University, 4.Laboratory of Food and Regulation Biology, Graduate School of Bioscience, Tokai University, 5.Takeda Pharmaceutical Company Ltd.)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-578(1T16a-10)] Analysis of molecular mechanisms of ciliary protein transport regulation in retinal photoreceptor cells

^〇Yamato Maeda^1,2, Taro Chaya^1,2, Ryotaro Tsutsumi^1,2, Makoto Ando^1,2, Yujie Ma^1,2, Masaki Nishi^1,2, Takahisa Furukawa^1,2 (1.Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 2.AMED-CREST, JST Moonshot R&D, COI-NEXT)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-579] EphA4 induces Dab1 phosphorylation via Src family kinase

^〇Takao Kohno¹, Mitsuki Hara¹, Keisuke Ishii¹, Mitsuharu Hattori¹ (Department of Biomedical Science, Graduate School of Pharmaceutical Sciences, Nagoya City University)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-580] Selective chemical modification of microglia in the live mouse brain

^〇Hiroshi Nonaka^1,2, Mengchu Wang¹, Itaru Hamachi^1,2 (1.Graduate School of Engineering, Kyoto University, 2.ERATO, JST)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-581] Analysis of gene expression profiles in the white matter tissue and microglia fraction prepared microglia-specific SIRPα knockout mice

^〇Shunya Hanzawa¹, Rui Mizutani¹, Etsumi Oike¹, Takeshi Imai¹, Eriko Urano¹, Eiko Matsumoto¹, Daiki Jingu², Yuriko Hayashi², Takashi Matozaki³, Hiroshi Ohnishi¹ (1.Dept Lab Sci, Gunma Univ Grad Sch Health Sci,Gunma, Japan, 2.Dept Med Tech, Gunma PAZ Univ Fac Med Sci Tech, Gunma, Japan, 3.Div Biosig Reg, Dept Biochem Mol Biol, Kobe Univ Grad Sch Med, Kobe, Japan)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-582(1T17a-01)] Caspase-11 contributes to SREBP1 activation in macrophage inflammatory response through Site-1 Protease Cleavage.

^〇Yinglan Cheng¹, Ichiro Manabe², Sumio Hayakawa¹, Yusuke Endo³, Yumiko Oishi¹ (1.Nippon Medical School, 2.Chiba University, 3.Kazusa DNA Research Institute,)

The 96th Annual Meeting of the Japanese Biochemical Society

[1P-583] Immunomodulatory effects of Kaempferol

^〇Miki Takahashi¹, Kazuki Nagata¹, Yumi Watanuki¹, Masaki Yamaguchi¹, Takuya Yashiro¹, Chiharu Nishiyama¹ (Department of Biological Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science)

The 96th Annual Meeting of the Japanese Biochemical Society