[2P-0728] The novel YAP1 activator induces a YAP1-p73 pathway-dependent apoptosis in human multiple myeloma cells

〇Junichi Maruyama¹, Xinliang Jiang¹, Hiroaki Iwasa¹, Mari Ishigami-Yuasa^2,3, Hiroyuki Kagechika^2,3, Hiroshi Nishina⁴, Yutaka Hata¹ (1.Medical Biochemistry, Grad. Sch. Med. Dent. Sci., Tokyo Medical and Dental Univ., 2.Chemical Biology Screening Center, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., 3.Organic and Medicinal Chemistry, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental Univ., 4.Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0729] Study of the growth inhibitory effect of Ridaifen for ovarian cancer cells

〇Yumiko Yokoe¹, Kotomi Akatsuka¹, Yuichi Nakashima², Akihito Mizusawa¹, Nozomi Ohta¹, Natsumi Shibata¹, Go Hasegawa³, Isamu Shiina², Motoyuki Shimonaka³ (1.Grad. Sch. of Chem. Sci. Tech.，Tokyo Univ. of Sci., 2.Dept. of Appl. Chem.，Fac. of Sci.，Tokyo Univ. of Sci., 3.Dept. of Chem.，Fac. of Sci.，Tokyo Univ. of Sci.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0730] Evaluation of specificity and efficacy of a drug targeting dormant cancer cells with a lung cancer cell line

〇Shiori Sakai¹, Tetsuya Kadonosono¹, Minori Endo¹, Takahiro Kuchimaru¹, Masahiro Inoue², Shinae Kondoh¹ (1.Dept. of Life Sci. and Tech., Sch. of Life Sci. and Tech., Tokyo Tech, 2.Osaka Medical Center for Cancer and Cardiovascular Diseases Research Institute)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0731] Analyses of limiting factors for the anti-tumor activity of nicotinamide phosphoribosyltransferase (NAMPT/NmPRT) inhibitors

〇Yusuke Takai¹, Akira Sato^1,2, Yoko Ogino¹, Kiyotaka Katuragi¹, Yuri Shibasaki¹, Takahiro Oyama³, Hideaki Abe³, Sei-ichi Tanuma^1,2 (1.Fac. Pharm. Sci., Tokyo Univ. Sci, 2.Genome & Drug Res. Ctr., Tokyo Univ. Sci, 3.Hinoki shinyaku Co., Ltd)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0732] Elucidating anticancer mechanism of a novel compound, NP-10

〇Masaki Yukuhiro¹, Yuka Iwasaki¹, Chika Tanaka¹, Makoto Ohira¹, Kazumasa Yoshida¹, Nozomi Sugimoto¹, Hiroyuki Morimoto², Takashi Ohshima², Hidetaka Kosako³, Masatoshi Fujita¹ (1.Dept. Cellular Biochem., Grad. Sch. Pharm Sci., Kyushu Univ., 2.Dept. Green Pharmaceutical Chem., Grad. Sch. Pharm Sci., Kyushu Univ., 3.Dept. Div. Cell Signal., Fujii Memorial Inst. Med. Sci., Tokushima Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0733] Anticancer mechanisms of anti-inflammatory candidate TLP-019 in human neuroblastoma

〇Kyousuke Kobayashi¹, Mika Shindo¹, Akira Sato^1,2, Atsushi Yoshimori³, Takahiro Oyama⁴, Hideaki Abe⁴, Koichi Ichimura⁵, Sei-ichi Tanuma^1,2 (1.Dept. of Biochem., Fac. of Pharm. Sci., Tokyo Univ. of Sci., 2.Genome & Drug Res. Ctr., Tokyo Univ. of Sci., 3.Inst. for Theoretical Med., Inc., 4.Hinoki Shinyaku Co., Ltd, 5.Div. of Brain Tumor Translational Res., Natl. Cancer Ctr. Res. Inst.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0734] Single low dose irradiation has suppressive effect on Xmrk induced tumorigenesis in Medaka (HdrR).

〇Bibek Dutta¹, Hiroshi Mitani¹ (1.Dept. of Integrated Biosciences, Grad. Sch. of Frontier Sci,, Univ. of Tokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0735] Nobiletin Induces Protective Autophagy Accompanied by ER-Stress Mediated Apoptosis in Human Gastric Cancer SNU-16 Cells

〇Jeong Yong Moon¹, Cho Somi Kim^1,2 (1.Subtropical/Tropical Organism Gene Bank, , Jeju National University, Korea, 2.Faculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Korea)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0736] Physical property and drug efficacy of recombinant fusion protein drug targeting HIF-active cancers

〇Takehiro Ito¹, Tetsuya Kadonosono¹, Thi Hong Ngoc Hoang¹, Takahiro Kuchimaru¹, Shinae Kondoh¹ (1.Sch. of Life Sci. & Tech., Tokyo Tech.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0737] Host EphA4 Regulates Paraneoplastic Leukemoid Reaction via G-CSFR Signal Pathway

〇Xuefenng Jing¹, Takashi Sonoki², Takahiro Sawada¹, Masayasu Miyajima³ (1.Dept. of Mol. Med., 2.Dept. of Hematology, 3.Laboratory Animal Center)

The 39th Annual Meeting of the Molecular Biology Society of Japan