[3P-0751] Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK–eIF2α–CHOP signaling

〇Takushi Namba¹ (1.Science Research Center, Univ. of Kochi)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0752] ASK1 in platelets and vascular endothelial cells coordinately regulates tumor lung metastasis

〇Miki Kamiyama¹, Isao Naguro¹, Hidenori Ichijo¹ (1.Cell Signaling, Grad. Sch. Pharm. Sci., UTokyo)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0753] Critical role of SREBP-driven mevalonate pathway in malignant properties of human melanoma cells revealed by a novel small molecule targeting SREBP processing

〇Yoshio Yamauchi^1,2, Kosei Ota¹, Mizuki Watanabe³, Masatomo Igarashi¹, Ryuichiro Sato², Motonari Uesugi³, Koichi Furukawa^1,4 (1.Dept. Biochem., Nagoya Univ. Grad. Sch. of Med., 2.Dept. Appl. Biol. Chem., Grad. Sch. of Agri. Life Sci., Univ. of Tokyo, 3.iCeMS, Kyoto Univ., 4.Dept. Life Biomed. Sci, Chubu Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0754] C57BL/6J-Ryr2^tm1Nobs and A/J-Ryr2^tm1Nobs mice as tools for exploring modifier genes in oncogenic K-ras driven lung tumorigenesis.

〇Hiromitsu Saito¹, Noboru Suzuki¹ (1.Dept. of Animal Genomics, Mie Univ. Life Sci. Res. Center)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0755] A novel anti-cancer DNA-alkylating Pyrrole-Imidazole polyamide by suppressing PD-L1 gene expression

〇Asuka Hattori^1,2, Kiriko Hiraoka^1,2, Jason Lin¹, Yoshinao Shinozaki¹, Hiroyuki Yoda^1,2, Takahiro Inoue^1,2, Takayoshi Watanabe¹, Atsushi Takatori¹, Nobuko Koshikawa¹, Hiroki Nagase^1,2 (1.Lab. Cancer Genetics, Chiba Cancer Center. Res. Inst., 2.Dept. of Molec. Biolo. and Oncol., Grad. Sch. Med. Pharma., Chiba Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0756] Continuous exposure to Imatinib disturbs energy metabolism of cancer cells and affect the efficacy of anti-cancer reagents

〇Takuya Hirao¹, Shigeki Aoki¹, Kousei Ito¹ (1.Lab. of Biopharm., Grad. Sch. of Pharm. Sci., Chiba Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0757] New Mathematical linkage analysis of transcriptome and methylome could identify the gene for cancer stem cel

〇Masamitsu Konno¹, Hidetoshi Matsui², Jun Koseki³, Ayumu Asai^1,3,4, Naohiro Nishida^1,4, Koichi Kawamoto⁴, Taroh Satoh¹, Masaki Mori⁴, Yuichiro Doki⁴, Hideshi Ishii³ (1.Dept. of Front. Sci. for Cancer and Chemotherapy, Grad. School of Med. Osaka Univ., 2.Facul. of Math. Kyushu Univ., 3.Dept. of Cancer Prof, Grad. School of Med. Osaka Univ., 4.Dept. of Surg., Grad. School of Med. Osaka Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0758] The acquired EGFR-TKI-resistance induced by expression of the histone demethylase, JARID1A

〇Eishin Mitsui¹, Yasumasa Matsumori¹, Hiroshi Tujii¹, Mie Tsuchida¹, Koshiki Mino¹, Shuichi Wada¹, Makoto Hasegawa¹, Ryuzo Sasaki¹, Tamio Mizukami¹ (1.Dept. of BioSci., Nagahama Inst. Bio-Sci. & Tech.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0759] Basic study for establishment of cisplatin-sensitization therapy by inhibition of MCM8/9

〇Sumiko Mori¹, Issei Morii¹, Kazumasa Yoshida¹, Nozomi Sugimoto¹, Masato Kanemaki², Masatoshi Fujita¹ (1.Dept. Cell. Biochem., Grad. Sch. Pharm. Sci., Kyushu Univ., 2.Cent. Front. Res., Nat. Inst. Genet.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[3P-0760] A new animal model of type 2 diabetes in Asians

〇Shin-ichi Chisada¹, Yasutoshi Yoshiura², Tadashi Andoh³, Julian Stolper⁴, Yasuhiro Kamei⁵, Kiyoshi Naruse⁶, Yoshihito Taniguchi¹ (1.Dept. of Preventive Med. & Public Hlth, Grad. Sch. of Med., Kyorin Univ., 2.Natl. Res. Inst. of Fisheries & Environm. of Inland Sea, Fisheries Res. & Educ. Agcy, 3.Seikai Natl. Fisheries Res. Inst., Japan Fisheries Res. & Educ. Agcy, 4.Ctr. for Organismal Studies, Heidelberg University, Germany, 5.Spectrography and Bioimaging Facility, NIBB, 6.Lab. of Bioresources, NIBB)

The 39th Annual Meeting of the Molecular Biology Society of Japan