[1T07a-08(1P-361)] SARS-CoV2 derived protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity

^〇Toshiya Oba¹, Daiki Homma¹, Taro Saito^1,2, Kanae Ando^1,2 (1.Department of Biological Sciences, Graduate School of Sciences, Tokyo Metropolitan University, 2.Department of Biological Sciences, Faculty of Sciences, Tokyo Metropolitan University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:43 PM - 2:52 PM

[1T07a-09(2P-371)] Structural Basis of GPCR Coupling Selectivity in the G12 Family

^〇Manae Tatsumi¹, Tatsuya Ikuta¹, Nozomi Kamakura¹, Asuka Inoue¹ (Dept. of Mol. Cell. Biochem., Grad. Sch. of Pharm. Sci., Tohoku Univ.)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:52 PM - 3:01 PM

[1T07a-10(1P-378)] Novel regulatory mechanisms of the MDM2-p53 pathway modulated by the ubiquitin ligase MKRN1

^〇Tatsuya Shimada¹, Yusuke Hirata¹, Takuya Noguchi¹, Atsushi Matsuzawa¹ (Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 3:01 PM - 3:10 PM

[1T07a-11(1P-375)] Development of a peptide-based compound that inhibits osteoclastogenesis by targeting TRAF6 to modulate its downstream signaling.

^〇Masataka Anzai¹, Miho Takahashi¹, Keizo Nishikawa², Hiroaki Sakurai³, Jun-ichiro Inoue⁴, Kiyotaka Nishikawa¹ (1.Lab. of Mol. Life Sci., Facult. of Life and Med. Sci., Doshisha Univ., 2.Lab. of Cell Biol. and Metab. Biochem., Facult. of Life and Med. Sci., Doshisha Univ., 3.Dep. of Cancer Cell Biol., Facul. of Pharma. Sci., Univ. of Toyama, 4.Res. Platform Office, The Inst. of Med. Sci., The Univ. of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 3:10 PM - 3:19 PM

[1T07a-12(1P-381)] Activation of STING requires cholesterol-mediated clustering at the TGN

^〇Haruka Kemmoku¹, Kanoko Takahashi¹, Kojiro Mukai¹, Yoshihiko Kuchitsu¹, Kenichi Suzuki², Tomohiko Taguchi¹ (1.Tohoku Univ., Graduate School of Life Sciences, 2.Gifu Univ., Institute for Glyco-Core Research)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 3:19 PM - 3:30 PM

[1T08a-01(2P-238)] The anti-inflammatory effect of xCT inhibition in a mouse model of inflammatory bowel disease

^〇Hideya Iwaki^1,2, Hiroki Sekine¹, Shohei Murakami¹, Nobufumi Kato³, Hiroshi Kitramura^3,4, Fanyan Wei⁵, Hideyo Sato⁶, Shinji Fukuda⁷, Tomoyoshi Soga⁷, Yoichi Kakuta², Atsushi Masamune², Hozumi Motohashi¹ (1.Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, 2.Division of Gastroenterology, Tohoku University, 3.Division of Advanced Surgical Science and Technology, Tohoku University, 4.Division of Microbiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, 5.Department of Modomics Biology and Medicine, Institute of Development, Aging and Cancer, Tohoku University, 6.Department of Health Sciences, School of Medicine,Niigata University, 7.Institute for Advanced Biosciences, Keio University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 1:40 PM - 1:49 PM

[1T08a-02(1P-241)] Identification of novel phosphatidylinositol-flippases and their cellular functions

^〇Yumeka Muranaka¹, Ryo Shigetomi¹, Yugo Iwasaki², Kazuhisa Nakayama¹, Hiroyuki Takatsu¹, Hye-Won Shin¹ (1.Graduate School of Pharmaceutical Sciences, Kyoto University, 2.Graduate School of Bioscience and Biotechnology, Chubu University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 1:49 PM - 1:58 PM

[1T08a-03(2P-236)] TORC1-dependent phosphorylation of a vacuolar amino acid transporter Avt4

^〇Haruka Terashita¹, Yusuke Yamamoto², Yumika Sato², Masaya Ishimoto², Haruka Kokumai¹, Akira Nozawa³, Hidetaka Kosako⁵, Tatsuya Sawasaki³, Takayuki Sekito^2,3, Miyuki Kawano-Kawada^2,3,4 (1.Faculty of Agriculture, Ehime University , 2.Graduate school of Agriculture, Ehime University , 3.Division of Cell-Free Sciences, Proteo-Science Center, Ehime University , 4.Division of Genetic Research Support, Advanced Research Support Center, Ehime University , 5.Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University )

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 1:58 PM - 2:07 PM

[1T08a-04(2P-244)] Analyses of cholesterol-sphingomyelin-rich membrane domains essential for tight junction formation

^〇Kenta Shigetomi¹, Yumiko Ono¹, Kenji Matsuzawa¹, Junichi Ikenouchi¹ (Department of Biology, Faculty of Science, Kyushu University)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:07 PM - 2:16 PM

[1T08a-05(1P-250)] Molecular basis of promoting centriole microtubule triplet assembly by the ciliopathy protein HYLS1

^〇Yutaka Takeda¹, Takumi Chinen¹, Shunnosuke Honda¹, Sho Takatori², Shotaro Okuda¹, Taisuke Tomita², Shoji Hata¹, Daiju Kitagawa¹ (1.Laboratory of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2.Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo)

The 96th Annual Meeting of the Japanese Biochemical Society |Tue. Oct 31, 2023 2:16 PM - 2:25 PM