[2P-675] Antitumor and antimetastatic effects of induction of soluble interleukin-33 receptor expression restricted to hypoxic regions in colorectal cancer

^〇Miho Akimoto¹, Takao Susa¹, Noriyuki Okudaira¹, Nobuko Koshikawa², Harumi Hisaki¹, Masayoshi Iizuka³, Keizo Takenaga², Mimi Tamamori-Adachi¹, (¹Dept. of Biochem., Teikyo Univ. Sch. of Med., ²Lab. Innov. Cancer Ther., Chiba Cancer Ctr. Res. Inst., ³Med. Educ. Ctr., Teikyo Univ. Sch. of Med.)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-676] Detection of unfolded protein response via proteasome inhibition at single cell level by simultaneous observation of bioluminescence and fluorescence and its availability for a drug evaluation

^〇Soma Irie¹, Motoya Hiraki¹, Makoto Hasegawa¹, Tomohisa Horibe¹ (Faculty of Medical bioscience, Nagahama Institute of Bio-Science)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-677] ACAT inhibitors suppress the proliferation and induce the senescence in bile duct carcinoma cells

^〇Tomoki Matsuo¹, Yasuomi Urano¹, Noriko Noguchi¹ (Graduate School of Life and Medical Sciences, Doshisha University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-678] Single-cell transcriptomic analysis reveals the early separation of neuroblastoma fate in Th-MYCN mice

^〇Shoma Tsubota¹, Kenji Kadomatsu² (¹Department of Molecular Biology, Nagoya University Graduate School of Medicine, ²Institute for Glyco-core Research)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-679] Clinical significance of intracytoplasmic lipid droplets in malignant lymphomas.

^〇Hiromu Yano¹, Yukio Fujiwara¹, Cheng Pan¹, Yoshihiro Komohara¹ (Department of Cell pathology, Graduate School of Medical Science, Faculty of Life Science, Kumamoto University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-680] Nervous system-dependent lifespan extension in C. elegans by procyanidin supplementation

^〇Keiya Ohmine¹, Aika Matsubara¹, Yuki Morinaga¹, Koichiro Sumi², Midori Natsume², Hideshi Inoue¹ (¹School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, ²Food Microbiology and Function Research Labs, Meiji Co)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-681] Prolyl isomerase FKBP5 activates hepatic stellate cells through promoting Smad3 phosphorylation.

^〇Shunya Aoyama¹, Mikako Nakanishi¹, Tomoichiro Asano¹, Yusuke Nakatsu¹ (Department of Medical Science, Graduate School of Medicine, Hiroshima University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-682] Effects of Klotho knockdown on amino acid starvation response and Nrf1 in Hep3B cells

^〇Tomoaki Kawamura¹, Sudarma Bogahawaththa^2,3, Kanade Shiga¹, Sho Nishida^3,4, Tadayuki Tsujita^1,2,3 (¹Laboratory of Biochemistry, Department of Health Function Molecular Science, Faculty of Advanced Health science, Saga University, ²Laboratory of Biochemistry, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, ³The United Graduate School of Agricultural Sciences, Kagoshima University, ⁴Faculty of Agriculture, Saga University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-683] Single-cell RNA sequencing to detect age-associated genes that identify senescent cells in the liver of aged mice.

^〇Yuta Doshida¹, Shinichi Hashimoto², Sadahiro Iwabuchi ², Yuka Takino¹, Toshiyuki Ishiwata¹, Toshiro Aigaki³, Akihito Ishigami^1,3, (¹Tokyo Metropolitan Institute for Geriatrics and Gerontology, ²Wakayama Medical University, ³Tokyo Metropolitan University)

The 96th Annual Meeting of the Japanese Biochemical Society

[2P-684] Mechanisms of adaptation of liver mitochondrial respiratory function in nonalcoholic fatty liver disease

^〇Kazuma Hamada¹ (Biopharmaceutics and Molecular Toxicology Unit, Faculty of Pharmaceutical Sciences, Teikyo Heisei University)

The 96th Annual Meeting of the Japanese Biochemical Society