[2P-0688] Transcriptional suppression of Dicer by HOXB-AS3/EZH2 complex dictates sorafenib resistance and cancer stemness

〇Chi-Feng Tseng^1,2, Jen-Liang Su^1,3,4,5 (1.National Institute of Cancer Research, National Health Research Institutes, Taiwan., 2.Graduate Program of Biotechnology in Medicine College of Life Science, National Tsing Hua University, Taiwan., 3.Graduate Institute of Cancer Biology, China Medical University, Taiwan., 4.Center for Molecular Medicine, China Medical University Hospital, Taiwan., 5.Department of Biotechnology, Asia University, Taiwan.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0689] Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL

〇Lichun Huang¹, Ting-Yu Chang¹, Hsin-An Chen^2,3,4, Ching-Feng Chiu¹, Yi-Wen Chang¹, Tsang-Chih Kuo⁵, Po-Chun Tseng⁶, Weu Wang⁷, Mien-Chie Hung^8,9, Jen-Liang Su^1,6,9,10 (1.National Institute of Cancer Research, National Health Research Institutes, Taiwan., 2.Department of General Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taiwan., 3.Division of General Surgery, Department of Surgery, Shuang Ho Hospital,Taipei Medical University, Taiwan., 4.Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taiwan., 5.Institute of Biochemical Sciences, College of Life Science, National Taiwan University, Taiwan., 6.Department of Biotechnology, Asia University, Taiwan., 7.Department of Surgery, Taipei Medical University Hospital, Taipei Medical University, Taiwan., 8.Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Texas., 9.Center for Molecular Medicine, China Medical University Hospital, Taiwan., 10.Graduate Institute of Cancer Biology, China Medical University, Taiwan)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0690(3AS13-3)] Identification of targets of tumor suppressor microRNA-34a using a reporter library system

〇Yoshiaki Ito¹, Atsushi Inoue², Timothy Seers¹, Yukari Hato³, Arisa Igarashi², Tatsuya Toyama³, Hiroshi Asahara^1,4 (1.Dept. Syst. BioMed. TMDU, 2.Dept. Syst. BioMed. NCHD, 3.Dept. Onco. Immun. Surgery. Nagoya City Univ., 4.Sccrips Res. Ins.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0691] Regulation of NF90-NF45 expression level through microRNA function in tumor cells.

Takuma Higuchi¹, Keiko Morisawa¹, Lai Sylvia Chin See¹, Takeshi Miwa¹, Eunsup Chi¹, Hiroshi Todaka², Yasunori Sugiyama³, Masayuki Tsuda⁴, 〇Shuji Sakamoto¹ (1.Lab. of Mol. Biol., Sci. Res. Cent., Kochi Med. Sch., Kochi Univ., 2.Dept. Cardiovascular Control, Kochi Med. Sch., Kochi Univ., 3.Dept. Appl. Biol. Sci., Fac. Agr., Kagawa Univ., 4.Div. of lab. Animal Sci., Sci. Res. Cent., Kochi Med. Sch., Kochi Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0692] Analysis of novel long-noncoding RNA induced by TGFβ

〇Satoshi Sakai¹, Tatsuya Ohhata¹, Masatoshi Kitagawa¹ (1.Dept. Mol. Biol., Hamamatsu Univ., Sch. of Med.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0693] Overexpression of NF90-NF45 leads to elevated tumorigenicity in vivo.

〇Takuma Higuchi¹, Takeshi Mira¹, Atsuya Nobumoto², Keiko Morisawa¹, Sylvia Chin See Lai¹, Eunsup Chi¹, Hiroshi Todaka³, Yasunori Sugiyama⁴, Masayuki Tsuda², Shuji Sakamoto¹ (1.Lab. of Mol. Biol., Sci. Res. Cent., Kochi Med. Sch., Kochi Univ., 2.Div.of lab. Animal Sci., Sci. Res. Cent., Kochi Med. Sch., Kochi Univ., 3.Dept. Cardiovascular Control, Kochi Med. Sch., Kochi Univ., 4.Dept. Appl. Biol. Sci., Fac. Agr., Kagawa Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0694] Bone metastatic mammary tumor cell-derived extracellular vesicles as positive regulator of osteoclastogenesis

〇Norihisa Uehara¹, Yukari Kyumoto¹, Akiko Kukita², Toshio Kukita¹ (1.Dept. of Mol. Cell Biol. and Oral Anat., Grad. Sch. of Dent. Sci., Kyushu Univ., 2.Dept. of Microbiol. Fuc. of Med., Saga Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0695] One carbon metabolism dependent epigenetic modifications in non-coding RNAs and their clinical relevance

〇Naohiro Nishida¹, Ken Ofusa⁴, Akira Yamagata⁴, Jun Koseki², Masamitsu Konno³, Koichi Kawamoto¹, Ayumu Asai², Tsunakazu Mizushima¹, Hidetoshi Eguchi¹, Shuji Takiguchi¹, Taroh Satoh³, Koshi Mimori⁵, Takahiro Ochiya⁶, Yuichiro Doki¹, Masaki Mori¹, Hideshi Ishii² (1.Gastrointestinal Surgery, Osaka University, 2.Cancer Profiling Discovery, Osaka University, 3.Department of Frontier Science for Cancer and Chemotherapy, Osaka University, 4.Idea Consultants, Inc., 5.Department of Surgery, Kyushu University Beppu Hospital, 6.Division of Molecular and Cellular Medicine, National Cancer Center Research Institute)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0696] Fine-tuning of p53-dependent nucleolus stress response by miR-101

〇Yuko Fujiwara¹, Takashi Kohno¹, Naoto Tsuchiya¹ (1.Div. Genome Biol., Natl. Cancer Ctr. Res. Inst.)

The 39th Annual Meeting of the Molecular Biology Society of Japan

[2P-0697] Analysis of the effect of mitochondrial function regulated by autophagy on cancer cell survival and sensitivity to anti-cancer agents

〇Shigeki Aoki¹, Michie Morita¹, Takuya Hirao¹, Moemi Kawaguchi¹, Kousei Ito¹ (1.Lab. of Biopharm., Grad. Sch. of Pharm. Sci., Chiba Univ.)

The 39th Annual Meeting of the Molecular Biology Society of Japan