*Ojiro Ishibashi^1,2, Chie Naruse², Masatoshi Ohgushi³, Takumi Nishiuchi⁴, Hirohiko Imai⁵, Tomoko Matsuzaki², Xuchi Pan², Fumihiro Sugiyama⁶, Masahide Asano² (1. Kyoto University. faculty of Medicine, 2. Kyoto University. Institute of Laboratory Animals, Graduate School of Medicine, 3. Kyoto University. Laboratory of developmental systems, Department of Biosystems Science, Institute for Life and Medical Sciences, 4. Kanazawa University. Division of Integrated Omics research, Bioscience Core Facility, Research Center for Experimental Modeling of Human Disease, 5. Kyoto University. Division of Systems informatics, Department of Systems Science, Graduate School of informatics, 6. University of Tsukuba. Laborarory Animal Resource Center, Transborder Medical Research Center, Faculty of Medicine)