[1O-Ca] Oral Session 3

[1C19] Live imaging of ERK MAPK and AMPK activity in patient-derived pancreatic cancer organoids reveals heterogeneous growth and drug responses in vitro and in vivo

*Toru Hiratsuka¹, Shoko Tsukamoto², Houssam Alkoussa², Akihito Machinaga³, Nobuyuki Kakiuchi⁴, Seishi Ogawa^5,6,7, Hiroshi Seno^7,4, Shigeki Higashiyama¹, Michiyuki Matsuda² (1. Oncogenesis and Growth Regulation, Research Center, Osaka International Cancer Institute, 2. Laboratory of Cell Cycle Regulation, Graduate School of Biostudies, Kyoto University, 3. Oncology Tsukuba Research Department, Discovery, Medicine Creation, OBG, Eisai Co., Ltd, 4. Department of Gastroenterology and Hepatology, Kyoto University, 5. Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, 6. Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, 7. Department of Medicine, Center for Hematology and Regenerative Medicine, Karolinska Institute, Sweden)

Keywords:Pancreatic cancer, ERK, AMPK, Live imaging, Heterogeneity